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The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.

Iakovleva I, Begum A, Pokrzywa M, Walfridsson M, Sauer-Eriksson AE, Olofsson A.

PLoS One. 2015 May 28;10(5):e0128222. doi: 10.1371/journal.pone.0128222. eCollection 2015.


Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models.

Grimm FA, Lehmler HJ, He X, Robertson LW, Duffel MW.

Chem Biol Interact. 2015 Feb 25;228:1-8. doi: 10.1016/j.cbi.2015.01.002. Epub 2015 Jan 13.


Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein.

Haupt M, Blakeley MP, Fisher SJ, Mason SA, Cooper JB, Mitchell EP, Forsyth VT.

IUCrJ. 2014 Oct 21;1(Pt 6):429-38. doi: 10.1107/S2052252514021113. eCollection 2014 Nov 1.


Cooperative stabilization of transthyretin by clusterin and diflunisal.

Greene MJ, Klimtchuk ES, Seldin DC, Berk JL, Connors LH.

Biochemistry. 2015 Jan 20;54(2):268-78. doi: 10.1021/bi5011249. Epub 2014 Dec 24.


Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs.

Castaño A, Drachman BM, Judge D, Maurer MS.

Heart Fail Rev. 2015 Mar;20(2):163-78. doi: 10.1007/s10741-014-9462-7.


Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems.

Hopping G, Kellock J, Caughey B, Daggett V.

ACS Med Chem Lett. 2013 Aug 1;4(9):824-8. doi: 10.1021/ml300478w. eCollection 2013 Sep 12.


Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW.

J Am Chem Soc. 2013 Apr 17;135(15):5656-68. doi: 10.1021/ja311729d. Epub 2013 Feb 14.


Statistical discovery of site inter-dependencies in sub-molecular hierarchical protein structuring.

Durston KK, Chiu DK, Wong AK, Li GC.

EURASIP J Bioinform Syst Biol. 2012 Jul 13;2012(1):8. doi: 10.1186/1687-4153-2012-8.


Diflunisal for ATTR cardiac amyloidosis.

Castaño A, Helmke S, Alvarez J, Delisle S, Maurer MS.

Congest Heart Fail. 2012 Nov-Dec;18(6):315-9. doi: 10.1111/j.1751-7133.2012.00303.x. Epub 2012 Jul 2.


Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34. doi: 10.1073/pnas.1121005109. Epub 2012 May 29.


The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW.

J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. Review.


Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis.

Lindquist SL, Kelly JW.

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a004507. doi: 10.1101/cshperspect.a004507. Review.


Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.

Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA.

Sci Transl Med. 2011 Aug 24;3(97):97ra81. doi: 10.1126/scitranslmed.3002473.


Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, Robinson CV, Wood SP, Pepys MB.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20483-8. doi: 10.1073/pnas.1008255107. Epub 2010 Nov 8.


Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.

Logan T, Clark L, Ray SS.

Biochemistry. 2010 Jul 13;49(27):5624-33. doi: 10.1021/bi902164h.


Significance of the amyloidogenic transthyretin Val 122 Ile allele in African Americans in the Arteriosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies.

Buxbaum J, Alexander A, Koziol J, Tagoe C, Fox E, Kitzman D.

Am Heart J. 2010 May;159(5):864-70. doi: 10.1016/j.ahj.2010.02.006.

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