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Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.

Ramani VC, Vlodavsky I, Ng M, Zhang Y, Barbieri P, Noseda A, Sanderson RD.

Matrix Biol. 2016 Mar 22. pii: S0945-053X(16)30030-0. doi: 10.1016/j.matbio.2016.03.006. [Epub ahead of print]


Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer.

Zheng L, Li D, Zhou YM, Yang H, Cheng D, Ma XX.

BMC Cancer. 2016 Feb 12;16:93. doi: 10.1186/s12885-016-2126-3.


Heparanase promotes myeloma progression by inducing mesenchymal features and motility of myeloma cells.

Li J, Pan Q, Rowan PD, Trotter TN, Peker D, Regal KM, Javed A, Suva LJ, Yang Y.

Oncotarget. 2016 Mar 8;7(10):11299-309. doi: 10.18632/oncotarget.7170.


Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma.

Lu A, Pallero MA, Lei W, Hong H, Yang Y, Suto MJ, Murphy-Ullrich JE.

Am J Pathol. 2016 Mar;186(3):678-90. doi: 10.1016/j.ajpath.2015.11.003. Epub 2016 Jan 20.


Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.

Weissmann M, Arvatz G, Horowitz N, Feld S, Naroditsky I, Zhang Y, Ng M, Hammond E, Nevo E, Vlodavsky I, Ilan N.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):704-9. doi: 10.1073/pnas.1519453113. Epub 2016 Jan 4.


Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma.

Ramani VC, Zhan F, He J, Barbieri P, Noseda A, Tricot G, Sanderson RD.

Oncotarget. 2016 Jan 12;7(2):1598-607. doi: 10.18632/oncotarget.6408.


Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.

Purushothaman A, Bandari SK, Liu J, Mobley JA, Brown EE, Sanderson RD.

J Biol Chem. 2016 Jan 22;291(4):1652-63. doi: 10.1074/jbc.M115.686295. Epub 2015 Nov 24.


Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells.

Garcia NA, Ontoria-Oviedo I, González-King H, Diez-Juan A, Sepúlveda P.

PLoS One. 2015 Sep 22;10(9):e0138849. doi: 10.1371/journal.pone.0138849. eCollection 2015.


Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.

Hadigal SR, Agelidis AM, Karasneh GA, Antoine TE, Yakoub AM, Ramani VC, Djalilian AR, Sanderson RD, Shukla D.

Nat Commun. 2015 Apr 27;6:6985. doi: 10.1038/ncomms7985.


Myeloma cell-derived Runx2 promotes myeloma progression in bone.

Trotter TN, Li M, Pan Q, Peker D, Rowan PD, Li J, Zhan F, Suva LJ, Javed A, Yang Y.

Blood. 2015 Jun 4;125(23):3598-608. doi: 10.1182/blood-2014-12-613968. Epub 2015 Apr 10.


Heparanase activates the syndecan-syntenin-ALIX exosome pathway.

Roucourt B, Meeussen S, Bao J, Zimmermann P, David G.

Cell Res. 2015 Apr;25(4):412-28. doi: 10.1038/cr.2015.29. Epub 2015 Mar 3.


Heparanase and coagulation-new insights.

Nadir Y.

Rambam Maimonides Med J. 2014 Oct 29;5(4):e0031. doi: 10.5041/RMMJ.10165. eCollection 2014 Oct.


Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme.

Hermano E, Meirovitz A, Meir K, Nussbaum G, Appelbaum L, Peretz T, Elkin M.

J Natl Cancer Inst. 2014 Oct 18;106(12). pii: dju332. doi: 10.1093/jnci/dju332. Print 2014 Dec.


Heparanase cooperates with Ras to drive breast and skin tumorigenesis.

Boyango I, Barash U, Naroditsky I, Li JP, Hammond E, Ilan N, Vlodavsky I.

Cancer Res. 2014 Aug 15;74(16):4504-14. doi: 10.1158/0008-5472.CAN-13-2962. Epub 2014 Jun 26.


Syndecans as modulators and potential pharmacological targets in cancer progression.

Barbouri D, Afratis N, Gialeli C, Vynios DH, Theocharis AD, Karamanos NK.

Front Oncol. 2014 Feb 3;4:4. doi: 10.3389/fonc.2014.00004. eCollection 2014. Review.


The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury.

van Golen RF, Reiniers MJ, Vrisekoop N, Zuurbier CJ, Olthof PB, van Rheenen J, van Gulik TM, Parsons BJ, Heger M.

Antioxid Redox Signal. 2014 Sep 1;21(7):1098-118. doi: 10.1089/ars.2013.5751. Epub 2014 Feb 19. Review.


Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma.

Hirshoren N, Bulvik R, Neuman T, Rubinstein AM, Meirovitz A, Elkin M.

J Cell Mol Med. 2014 Jan;18(1):181-6. doi: 10.1111/jcmm.12179. Epub 2013 Nov 28.


Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice.

Lerner I, Zcharia E, Neuman T, Hermano E, Rubinstein AM, Vlodavsky I, Elkin M.

Cell Mol Life Sci. 2014 Jun;71(12):2347-57. doi: 10.1007/s00018-013-1496-9. Epub 2013 Oct 30.


Heparanase-A Link between Coagulation, Angiogenesis, and Cancer.

Nadir Y, Brenner B.

Rambam Maimonides Med J. 2012 Jan 31;3(1):e0002. doi: 10.5041/RMMJ.10069. Print 2012 Jan.


Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications.

Vlodavsky I, Elkin M, Ilan N.

Rambam Maimonides Med J. 2011 Jan 31;2(1):e0019. doi: 10.5041/RMMJ.10019. Print 2011 Jan.

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