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Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story.

He F, Jacobson A.

Annu Rev Genet. 2015;49:339-66. doi: 10.1146/annurev-genet-112414-054639. Epub 2015 Oct 2.


Nonsense mutations in the rhodopsin gene that give rise to mild phenotypes trigger mRNA degradation in human cells by nonsense-mediated decay.

Roman-Sanchez R, Wensel TG, Wilson JH.

Exp Eye Res. 2016 Apr;145:444-9. doi: 10.1016/j.exer.2015.09.013. Epub 2015 Sep 26.


The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease.

Robinson SR, Oliver AW, Chevassut TJ, Newbury SF.

Biomolecules. 2015 Jul 17;5(3):1515-39. doi: 10.3390/biom5031515. Review.


Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity.

Pereira FJ, Teixeira A, Kong J, Barbosa C, Silva AL, Marques-Ramos A, Liebhaber SA, Romão L.

Nucleic Acids Res. 2015 Jul 27;43(13):6528-44. doi: 10.1093/nar/gkv588. Epub 2015 Jun 11.


Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.

Tummala H, Walne A, Collopy L, Cardoso S, de la Fuente J, Lawson S, Powell J, Cooper N, Foster A, Mohammed S, Plagnol V, Vulliamy T, Dokal I.

J Clin Invest. 2015 May;125(5):2151-60. doi: 10.1172/JCI78963. Epub 2015 Apr 20.


Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.

Popp MW, Maquat LE.

Nat Commun. 2015 Mar 26;6:6632. doi: 10.1038/ncomms7632.


NMD: At the crossroads between translation termination and ribosome recycling.

Celik A, Kervestin S, Jacobson A.

Biochimie. 2015 Jul;114:2-9. doi: 10.1016/j.biochi.2014.10.027. Epub 2014 Nov 13. Review.


Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.

Lykke-Andersen S, Chen Y, Ardal BR, Lilje B, Waage J, Sandelin A, Jensen TH.

Genes Dev. 2014 Nov 15;28(22):2498-517. doi: 10.1101/gad.246538.114. Erratum in: Genes Dev. 2016 May 1;30(9):1128-34.


A highly conserved region essential for NMD in the Upf2 N-terminal domain.

Fourati Z, Roy B, Millan C, Coureux PD, Kervestin S, van Tilbeurgh H, He F, Usón I, Jacobson A, Graille M.

J Mol Biol. 2014 Nov 11;426(22):3689-702. doi: 10.1016/j.jmb.2014.09.015. Epub 2014 Sep 30.


A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.

Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE.

Genes Dev. 2014 Sep 1;28(17):1900-16. doi: 10.1101/gad.245506.114.


Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency.

Seyedali A, Berry MJ.

RNA. 2014 Aug;20(8):1248-56. doi: 10.1261/rna.043463.113. Epub 2014 Jun 19.


The dharma of nonsense-mediated mRNA decay in mammalian cells.

Popp MW, Maquat LE.

Mol Cells. 2014 Jan;37(1):1-8. doi: 10.14348/molcells.2014.2193. Epub 2014 Jan 27. Review.


Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.

Jobert L, Nilsen H.

Cell Mol Life Sci. 2014 Jul;71(13):2451-65. doi: 10.1007/s00018-014-1562-y. Epub 2014 Feb 5. Review.


Organizing principles of mammalian nonsense-mediated mRNA decay.

Popp MW, Maquat LE.

Annu Rev Genet. 2013;47:139-65. doi: 10.1146/annurev-genet-111212-133424. Review.


Nonsense-mediated mRNA decay: inter-individual variability and human disease.

Nguyen LS, Wilkinson MF, Gecz J.

Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:175-86. doi: 10.1016/j.neubiorev.2013.10.016. Epub 2013 Nov 14. Review.


Intra- and intermolecular regulatory interactions in Upf1, the RNA helicase central to nonsense-mediated mRNA decay in yeast.

He F, Ganesan R, Jacobson A.

Mol Cell Biol. 2013 Dec;33(23):4672-84. doi: 10.1128/MCB.01136-13. Epub 2013 Oct 7.


Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways.

Metze S, Herzog VA, Ruepp MD, Mühlemann O.

RNA. 2013 Oct;19(10):1432-48. doi: 10.1261/rna.038893.113. Epub 2013 Aug 20.


Assembly of the yeast exoribonuclease Rrp6 with its associated cofactor Rrp47 occurs in the nucleus and is critical for the controlled expression of Rrp47.

Feigenbutz M, Jones R, Besong TM, Harding SE, Mitchell P.

J Biol Chem. 2013 May 31;288(22):15959-70. doi: 10.1074/jbc.M112.445759. Epub 2013 Apr 11.


XRN 5'→3' exoribonucleases: structure, mechanisms and functions.

Nagarajan VK, Jones CI, Newbury SF, Green PJ.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):590-603. doi: 10.1016/j.bbagrm.2013.03.005. Epub 2013 Mar 19. Review.

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