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Items: 1 to 20 of 42


Spectrum of UGT1A1 Variations in Chinese Patients with Crigler-Najjar Syndrome Type II.

Li L, Deng G, Tang Y, Mao Q.

PLoS One. 2015 May 20;10(5):e0126263. doi: 10.1371/journal.pone.0126263. eCollection 2015.


Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain.

Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Dispos. 2015 Jul;43(7):1071-6. doi: 10.1124/dmd.115.063719. Epub 2015 May 7.


Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes.

Kutsuno Y, Sumida K, Itoh T, Tukey RH, Fujiwara R.

Pharmacol Res Perspect. 2013 Oct;1(1):e00002. doi: 10.1002/prp2.2. Epub 2013 Sep 3.


Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting.

Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM.

Pharmacogenomics. 2014 Nov;15(14):1739-1747.


Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice.

Kutsuno Y, Itoh T, Tukey RH, Fujiwara R.

Drug Metab Dispos. 2014 Jul;42(7):1146-52. doi: 10.1124/dmd.114.057083. Epub 2014 Apr 24.


Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia.

Shibuya A, Itoh T, Tukey RH, Fujiwara R.

Sci Rep. 2013 Oct 9;3:2903. doi: 10.1038/srep02903.


Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia.

Sumida K, Kawana M, Kouno E, Itoh T, Takano S, Narawa T, Tukey RH, Fujiwara R.

Mol Pharmacol. 2013 Nov;84(5):679-86. doi: 10.1124/mol.113.088112. Epub 2013 Aug 15.


Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.

Meech R, Rogers A, Zhuang L, Lewis BC, Miners JO, Mackenzie PI.

J Biol Chem. 2012 Jul 13;287(29):24122-30. doi: 10.1074/jbc.M112.343608. Epub 2012 May 23.


Genetic variations and haplotype diversity of the UGT1 gene cluster in the Chinese population.

Yang J, Cai L, Huang H, Liu B, Wu Q.

PLoS One. 2012;7(4):e33988. doi: 10.1371/journal.pone.0033988. Epub 2012 Apr 13.


mRNA transcript diversity creates new opportunities for pharmacological intervention.

Barrie ES, Smith RM, Sanford JC, Sadee W.

Mol Pharmacol. 2012 May;81(5):620-30. doi: 10.1124/mol.111.076604. Epub 2012 Feb 7. Review.


Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome.

Matsui K, Maruo Y, Sato H, Takeuchi Y.

BMC Gastroenterol. 2010 Jun 8;10:57. doi: 10.1186/1471-230X-10-57.


Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity.

Huang H, Wu Q.

PLoS One. 2010 Feb 10;5(2):e9144. doi: 10.1371/journal.pone.0009144.


Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions.

Bellemare J, Rouleau M, Harvey M, Guillemette C.

J Biol Chem. 2010 Feb 5;285(6):3600-7. doi: 10.1074/jbc.M109.083139. Epub 2009 Dec 8.


Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.

Argikar UA, Senekeo-Effenberger K, Larson EE, Tukey RH, Remmel RP.

Xenobiotica. 2009 Nov;39(11):826-35. doi: 10.3109/00498250903188985.


Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

Runge-Morris M, Kocarek TA.

PPAR Res. 2009;2009:728941. doi: 10.1155/2009/728941. Epub 2009 Aug 10.


Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase.

Mackenzie PI, Rogers A, Treloar J, Jorgensen BR, Miners JO, Meech R.

J Biol Chem. 2008 Dec 26;283(52):36205-10. doi: 10.1074/jbc.M807961200. Epub 2008 Nov 3.


Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.

Berk PD.

Hepatology. 2008 Nov;48(5):1362-76. doi: 10.1002/hep.22632. Review. No abstract available.


Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element.

Falkner KC, Ritter JK, Prough RA.

Drug Metab Dispos. 2008 Feb;36(2):409-17. Epub 2007 Nov 26.


Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.

Li X, Bratton S, Radominska-Pandya A.

Drug Metab Pharmacokinet. 2007 Jun;22(3):152-61.

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