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Results: 1 to 20 of 113

1.

Employing novel animal models in the design of clinically efficacious GPCR ligands.

Bradley SJ, Riaz SA, Tobin AB.

Curr Opin Cell Biol. 2014 Apr;27:117-25. doi: 10.1016/j.ceb.2013.12.002. Epub 2013 Dec 31. Review.

PMID:
24680437
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.

Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P; GenTAC Registry Consortium, Costa KD, Hajjar RJ, Ramirez F.

J Clin Invest. 2014 Mar 3;124(3):1329-39. doi: 10.1172/JCI71059. Epub 2014 Feb 17.

PMID:
24531548
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Minireview: Targeting GPCR Activated ERK Pathways for Drug Discovery.

Eishingdrelo H, Kongsamut S.

Curr Chem Genomics Transl Med. 2013 Jul 26;7:9-15. doi: 10.2174/2213988501307010009. eCollection 2013.

PMID:
24396730
[PubMed]
Free PMC Article
4.

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor.

Nickolls SA, Humphreys S, Clark M, McMurray G.

PLoS One. 2013 Dec 20;8(12):e83691. doi: 10.1371/journal.pone.0083691. eCollection 2013.

PMID:
24376730
[PubMed - in process]
Free PMC Article
5.

ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

Sánchez-Fernández G, Cabezudo S, García-Hoz C, Tobin AB, Mayor F Jr, Ribas C.

PLoS One. 2013 Dec 17;8(12):e84174. doi: 10.1371/journal.pone.0084174. eCollection 2013.

PMID:
24358341
[PubMed - in process]
Free PMC Article
6.

Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.

Nelson CD, Sheng M.

PLoS One. 2013 Sep 12;8(9):e74680. doi: 10.1371/journal.pone.0074680. eCollection 2013.

PMID:
24069330
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin.

Larsen AK, Kristiansen K, Sylte I, Seternes OM, Bang BE.

BMC Res Notes. 2013 Jul 20;6:281. doi: 10.1186/1756-0500-6-281.

PMID:
23870109
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers.

Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA.

J Biol Chem. 2013 Jun 28;288(26):18872-84. doi: 10.1074/jbc.M113.472381. Epub 2013 May 9.

PMID:
23661707
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER.

Gigoux V, Fourmy D.

Front Endocrinol (Lausanne). 2013 Apr 29;4:50. doi: 10.3389/fendo.2013.00050. eCollection 2013.

PMID:
23641235
[PubMed]
Free PMC Article
10.

Angiotensin II activates NF-κB through AT1A receptor recruitment of β-arrestin in cultured rat vascular smooth muscle cells.

Morinelli TA, Lee MH, Kendall RT, Luttrell LM, Walker LP, Ullian ME.

Am J Physiol Cell Physiol. 2013 Jun 15;304(12):C1176-86. doi: 10.1152/ajpcell.00235.2012. Epub 2013 Apr 10.

PMID:
23576578
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Regulation of G protein-coupled receptors by allosteric ligands.

Lane JR, Abdul-Ridha A, Canals M.

ACS Chem Neurosci. 2013 Apr 17;4(4):527-34. doi: 10.1021/cn400005t. Epub 2013 Feb 21. Review.

PMID:
23398684
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum.

Harrison LM, Muller SH, Spano D.

Neuroscience. 2013 Apr 16;236:21-30. doi: 10.1016/j.neuroscience.2012.12.062. Epub 2013 Feb 1.

PMID:
23380502
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Signaling effectors underlying pathologic growth and remodeling of the heart.

van Berlo JH, Maillet M, Molkentin JD.

J Clin Invest. 2013 Jan 2;123(1):37-45. doi: 10.1172/JCI62839. Epub 2013 Jan 2. Review.

PMID:
23281408
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Non-traditional roles of G protein-coupled receptors in basic cell biology.

Zhang X, Eggert US.

Mol Biosyst. 2013 Apr 5;9(4):586-95. doi: 10.1039/c2mb25429h. Review.

PMID:
23247090
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling.

Marchese A, Trejo J.

Cell Signal. 2013 Mar;25(3):707-16. doi: 10.1016/j.cellsig.2012.11.024. Epub 2012 Nov 29. Review.

PMID:
23201781
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Conducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic Approaches.

Belmonte SL, Blaxall BC.

Drug Discov Today Dis Models. 2012;9(3):e85-e90. Epub 2012 Jun 27.

PMID:
23162605
[PubMed]
Free PMC Article
17.

Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor.

Gregory KJ, Sexton PM, Tobin AB, Christopoulos A.

J Biol Chem. 2012 Oct 26;287(44):37066-77. doi: 10.1074/jbc.M112.408534. Epub 2012 Sep 10.

PMID:
22965232
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The potential for selective pharmacological therapies through biased receptor signaling.

Kenakin T.

BMC Pharmacol Toxicol. 2012 Aug 13;13:3. doi: 10.1186/2050-6511-13-3. Review.

PMID:
22947056
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.

Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.

J Biol Chem. 2012 Oct 12;287(42):35669-77. doi: 10.1074/jbc.M112.357871. Epub 2012 Aug 10.

PMID:
22888001
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.

Kim KS, Abraham D, Williams B, Violin JD, Mao L, Rockman HA.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H1001-10. doi: 10.1152/ajpheart.00475.2012. Epub 2012 Aug 10.

PMID:
22886417
[PubMed - indexed for MEDLINE]
Free PMC Article

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