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Results: 1 to 20 of 147

1.

Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology.

Wang Y, Thinakaran G, Kar S.

PLoS One. 2014 May 20;9(5):e98057. doi: 10.1371/journal.pone.0098057. eCollection 2014.

PMID:
24846272
[PubMed - in process]
Free PMC Article
2.

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation.

Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T.

Mol Neurodegener. 2014 Jan 13;9:7. doi: 10.1186/1750-1326-9-7.

PMID:
24410857
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Trafficking regulation of proteins in Alzheimer's disease.

Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW.

Mol Neurodegener. 2014 Jan 11;9:6. doi: 10.1186/1750-1326-9-6. Review.

PMID:
24410826
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE.

Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22.

PMID:
24401146
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Targeting γ-secretase in breast cancer.

Han J, Shen Q.

Breast Cancer (Dove Med Press). 2012 Jun 21;4:83-90. doi: 10.2147/BCTT.S26437. Review.

PMID:
24367196
[PubMed]
Free PMC Article
6.

Γ-secretase components as predictors of breast cancer outcome.

Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A.

PLoS One. 2013 Nov 1;8(11):e79249. doi: 10.1371/journal.pone.0079249. eCollection 2013.

PMID:
24223915
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y.

Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529.

PMID:
24108142
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

532 nm low-power laser irradiation recovers γ-secretase inhibitor-mediated cell growth suppression and promotes cell proliferation via Akt signaling.

Fukuzaki Y, Sugawara H, Yamanoha B, Kogure S.

PLoS One. 2013 Aug 7;8(8):e70737. doi: 10.1371/journal.pone.0070737. eCollection 2013.

PMID:
23950991
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Biological function of Presenilin and its role in AD pathogenesis.

Zhang S, Zhang M, Cai F, Song W.

Transl Neurodegener. 2013 Jul 17;2(1):15. doi: 10.1186/2047-9158-2-15.

PMID:
23866842
[PubMed]
Free PMC Article
10.

Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA.

Bandara S, Malmersjö S, Meyer T.

Sci Signal. 2013 Jul 9;6(283):ra56. doi: 10.1126/scisignal.2003649.

PMID:
23838183
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.

Schedin-Weiss S, Inoue M, Teranishi Y, Yamamoto NG, Karlström H, Winblad B, Tjernberg LO.

PLoS One. 2013 May 24;8(5):e63962. doi: 10.1371/journal.pone.0063962. Print 2013.

PMID:
23717518
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration.

McInnes J.

Transl Neurodegener. 2013 May 27;2(1):12. doi: 10.1186/2047-9158-2-12.

PMID:
23711354
[PubMed]
Free PMC Article
13.

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity.

Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW.

Neurosci Lett. 2013 Aug 26;548:90-4. doi: 10.1016/j.neulet.2013.05.018. Epub 2013 May 15.

PMID:
23685131
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.

Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T.

PLoS One. 2013 May 7;8(5):e64050. doi: 10.1371/journal.pone.0064050. Print 2013.

PMID:
23667698
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Development and mechanism of γ-secretase modulators for Alzheimer's disease.

Crump CJ, Johnson DS, Li YM.

Biochemistry. 2013 May 14;52(19):3197-216. doi: 10.1021/bi400377p. Epub 2013 May 2. Review.

PMID:
23614767
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural biology of presenilins and signal peptide peptidases.

Tomita T, Iwatsubo T.

J Biol Chem. 2013 May 24;288(21):14673-80. doi: 10.1074/jbc.R113.463281. Epub 2013 Apr 12. Review.

PMID:
23585568
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

Grimm MO, Haupenthal VJ, Rothhaar TL, Zimmer VC, Grösgen S, Hundsdörfer B, Lehmann J, Grimm HS, Hartmann T.

Int J Mol Sci. 2013 Mar 13;14(3):5879-98. doi: 10.3390/ijms14035879.

PMID:
23485990
[PubMed]
Free PMC Article
18.

Leptin signaling and Alzheimer's disease.

Marwarha G, Ghribi O.

Am J Neurodegener Dis. 2012;1(3):245-65. Epub 2012 Nov 18.

PMID:
23383396
[PubMed]
Free PMC Article
19.
20.

β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology.

Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, Pei G.

Cell Res. 2013 Mar;23(3):351-65. doi: 10.1038/cr.2012.167. Epub 2012 Dec 4.

PMID:
23208420
[PubMed - indexed for MEDLINE]
Free PMC Article

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