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Items: 1 to 20 of 24


Protein kinase C controls activation of the DNA integrity checkpoint.

Soriano-Carot M, Quilis I, Bañó MC, Igual JC.

Nucleic Acids Res. 2014 Jun;42(11):7084-95. doi: 10.1093/nar/gku373. Epub 2014 May 3.


Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.

Bandhu A, Kang J, Fukunaga K, Goto G, Sugimoto K.

PLoS Genet. 2014 Feb 20;10(2):e1004136. doi: 10.1371/journal.pgen.1004136. eCollection 2014 Feb.


Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae.

Litwin I, Bocer T, Dziadkowiec D, Wysocki R.

PLoS Genet. 2013;9(7):e1003640. doi: 10.1371/journal.pgen.1003640. Epub 2013 Jul 25.


Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency.

Di Domenico EG, Mattarocci S, Cimino-Reale G, Parisi P, Cifani N, D'Ambrosio E, Zakian VA, Ascenzioni F.

Nucleic Acids Res. 2013 Jul;41(13):6490-500. doi: 10.1093/nar/gkt365. Epub 2013 May 15.


Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.

Teixeira MT.

Front Oncol. 2013 Apr 26;3:101. doi: 10.3389/fonc.2013.00101. eCollection 2013.


Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity.

Menotta M, Biagiotti S, Bianchi M, Chessa L, Magnani M.

J Biol Chem. 2012 Nov 30;287(49):41352-63. doi: 10.1074/jbc.M112.344473. Epub 2012 Oct 10.


The recombinases DMC1 and RAD51 are functionally and spatially separated during meiosis in Arabidopsis.

Kurzbauer MT, Uanschou C, Chen D, Schlögelhofer P.

Plant Cell. 2012 May;24(5):2058-70. doi: 10.1105/tpc.112.098459. Epub 2012 May 15.


Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast.

Fukunaga K, Hirano Y, Sugimoto K.

Mol Biol Cell. 2012 Jan;23(2):347-59. doi: 10.1091/mbc.E11-06-0568. Epub 2011 Nov 30.


Activation of protein kinase Tel1 through recognition of protein-bound DNA ends.

Fukunaga K, Kwon Y, Sung P, Sugimoto K.

Mol Cell Biol. 2011 May;31(10):1959-71. doi: 10.1128/MCB.05157-11. Epub 2011 Mar 14.


A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.

Kondo S, Perrimon N.

Sci Signal. 2011 Jan 4;4(154):rs1. doi: 10.1126/scisignal.2001350.


Rif1 and rif2 inhibit localization of tel1 to DNA ends.

Hirano Y, Fukunaga K, Sugimoto K.

Mol Cell. 2009 Feb 13;33(3):312-22. doi: 10.1016/j.molcel.2008.12.027.


Role of budding yeast Rad18 in repair of HO-induced double-strand breaks.

Hirano Y, Reddy J, Sugimoto K.

DNA Repair (Amst). 2009 Jan 1;8(1):51-9. doi: 10.1016/j.dnarep.2008.08.013. Epub 2008 Oct 11.


E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair.

Chen D, Yu Z, Zhu Z, Lopez CD.

J Biol Chem. 2008 May 30;283(22):15381-9. doi: 10.1074/jbc.M710296200. Epub 2008 Mar 17.


Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH.

Genes Dev. 2008 Apr 1;22(7):854-9. doi: 10.1101/gad.1646208. Epub 2008 Mar 11.


Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends.

Hirano Y, Sugimoto K.

Mol Biol Cell. 2007 Jun;18(6):2026-36. Epub 2007 Mar 21.


Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.

Wysocki R, Javaheri A, Allard S, Sha F, Côté J, Kron SJ.

Mol Cell Biol. 2005 Oct;25(19):8430-43.


Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.

Nakada D, Hirano Y, Tanaka Y, Sugimoto K.

Mol Biol Cell. 2005 Nov;16(11):5227-35. Epub 2005 Sep 7.


A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1.

Clerici M, Baldo V, Mantiero D, Lottersberger F, Lucchini G, Longhese MP.

Mol Cell Biol. 2004 Dec;24(23):10126-44.


Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.

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