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Oxidative DNA damage stalls the human mitochondrial replisome.

Stojkovič G, Makarova AV, Wanrooij PH, Forslund J, Burgers PM, Wanrooij S.

Sci Rep. 2016 Jul 1;6:28942. doi: 10.1038/srep28942.


Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins.

Jay KA, Smith DL, Blackburn EH.

Mol Cell Biol. 2016 Jun 29;36(14):1908-19. doi: 10.1128/MCB.00943-15. Print 2016 Jul 15.


The mutation spectrum in genomic late replication domains shapes mammalian GC content.

Kenigsberg E, Yehuda Y, Marjavaara L, Keszthelyi A, Chabes A, Tanay A, Simon I.

Nucleic Acids Res. 2016 May 19;44(9):4222-32. doi: 10.1093/nar/gkw268. Epub 2016 Apr 16.


Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.

Rentoft M, Lindell K, Tran P, Chabes AL, Buckland RJ, Watt DL, Marjavaara L, Nilsson AK, Melin B, Trygg J, Johansson E, Chabes A.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4723-8. doi: 10.1073/pnas.1519128113. Epub 2016 Apr 11.


Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale.

Stodola JL, Burgers PM.

Nat Struct Mol Biol. 2016 May;23(5):402-8. doi: 10.1038/nsmb.3207. Epub 2016 Apr 11.


Transcriptome Analysis of Escherichia coli during dGTP Starvation.

Itsko M, Schaaper RM.

J Bacteriol. 2016 May 13;198(11):1631-44. doi: 10.1128/JB.00218-16. Print 2016 Jun 1.


The Balancing Act of Ribonucleotides in DNA.

Cerritelli SM, Crouch RJ.

Trends Biochem Sci. 2016 May;41(5):434-45. doi: 10.1016/j.tibs.2016.02.005. Epub 2016 Mar 17. Review.


Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency.

Sanvisens N, Romero AM, Zhang C, Wu X, An X, Huang M, Puig S.

J Biol Chem. 2016 Apr 29;291(18):9807-17. doi: 10.1074/jbc.M116.720862. Epub 2016 Mar 12.


Eukaryotic genome instability in light of asymmetric DNA replication.

Lujan SA, Williams JS, Kunkel TA.

Crit Rev Biochem Mol Biol. 2016;51(1):43-52. doi: 10.3109/10409238.2015.1117055. Epub 2015 Dec 20.


Microbial 2-Cys Peroxiredoxins: Insights into Their Complex Physiological Roles.

Toledano MB, Huang B.

Mol Cells. 2016 Jan;39(1):31-9. doi: 10.14348/molcells.2016.2326. Epub 2016 Jan 25. Review.


S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.

Earp C, Rowbotham S, Merényi G, Chabes A, Cha RS.

Biol Open. 2015 Nov 24;4(12):1739-43. doi: 10.1242/bio.015347.


Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients.

Maynard S, Hejl AM, Dinh TS, Keijzers G, Hansen ÅM, Desler C, Moreno-Villanueva M, Bürkle A, Rasmussen LJ, Waldemar G, Bohr VA.

Aging (Albany NY). 2015 Oct;7(10):793-815.


Genetic instability in budding and fission yeast-sources and mechanisms.

Skoneczna A, Kaniak A, Skoneczny M.

FEMS Microbiol Rev. 2015 Nov;39(6):917-67. doi: 10.1093/femsre/fuv028. Epub 2015 Jun 24. Review.


A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

Specks J, Lecona E, Lopez-Contreras AJ, Fernandez-Capetillo O.

Mol Cell Biol. 2015 Sep 1;35(17):2910-7. doi: 10.1128/MCB.00475-15. Epub 2015 Jun 15.


Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.

St Charles JA, Liberti SE, Williams JS, Lujan SA, Kunkel TA.

DNA Repair (Amst). 2015 Jul;31:41-51. doi: 10.1016/j.dnarep.2015.04.006. Epub 2015 Apr 25.


Yet another job for Dna2: Checkpoint activation.

Wanrooij PH, Burgers PM.

DNA Repair (Amst). 2015 Aug;32:17-23. doi: 10.1016/j.dnarep.2015.04.009. Epub 2015 May 1. Review.


Pools and Pols: Mechanism of a mutator phenotype.

Sohl CD, Ray S, Sweasy JB.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):5864-5. doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30. No abstract available.


Nucleotide salvage deficiencies, DNA damage and neurodegeneration.

Fasullo M, Endres L.

Int J Mol Sci. 2015 Apr 27;16(5):9431-49. doi: 10.3390/ijms16059431. Review.


Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses.

Endres L, Dedon PC, Begley TJ.

RNA Biol. 2015;12(6):603-14. doi: 10.1080/15476286.2015.1031947. Review.


Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.

Mertz TM, Sharma S, Chabes A, Shcherbakova PV.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2467-76. doi: 10.1073/pnas.1422934112. Epub 2015 Mar 31.

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