Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 62

1.

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.

Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, Filhol E, Niel O, Silbermann F, Lebreton C, Collardeau-Frachon S, Rouvet I, Alessandri JL, Devisme L, Dieux-Coeslier A, Cordier MP, Capri Y, Khung-Savatovsky S, Sigaudy S, Salomon R, Antignac C, Gubler MC, Benmerah A, Terzi F, Attié-Bitach T, Jeanpierre C, Saunier S.

PLoS Genet. 2016 Mar 11;12(3):e1005894. doi: 10.1371/journal.pgen.1005894. eCollection 2016 Mar.

2.

Genetic spectrum of Saudi Arabian patients with antenatal cystic kidney disease and ciliopathy phenotypes using a targeted renal gene panel.

Al-Hamed MH, Kurdi W, Alsahan N, Alabdullah Z, Abudraz R, Tulbah M, Alnemer M, Khan R, Al-Jurayb H, Alahmed A, Tahir AI, Khalil D, Edwards N, Al Abdulaziz B, Binhumaid FS, Majid S, Faquih T, El-Kalioby M, Abouelhoda M, Altassan N, Monies D, Meyer B, Sayer JA, Albaqumi M.

J Med Genet. 2016 May;53(5):338-47. doi: 10.1136/jmedgenet-2015-103469. Epub 2016 Feb 9.

3.

The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function.

Cantero Mdel R, Velázquez IF, Streets AJ, Ong AC, Cantiello HF.

J Biol Chem. 2015 Sep 25;290(39):23888-96. doi: 10.1074/jbc.M115.661082. Epub 2015 Aug 12.

PMID:
26269590
4.

A polycystin-centric view of cyst formation and disease: the polycystins revisited.

Ong AC, Harris PC.

Kidney Int. 2015 Oct;88(4):699-710. doi: 10.1038/ki.2015.207. Epub 2015 Jul 22. Review.

5.

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV.

Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023.

6.

C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.

Yochem J, Lažetić V, Bell L, Chen L, Fay D.

Dev Biol. 2015 Feb 15;398(2):255-66. doi: 10.1016/j.ydbio.2014.12.008. Epub 2014 Dec 16.

7.

A possible zebrafish model of polycystic kidney disease: knockdown of wnt5a causes cysts in zebrafish kidneys.

Huang L, Xiao A, Wecker A, McBride DA, Choi SY, Zhou W, Lipschutz JH.

J Vis Exp. 2014 Dec 2;(94). doi: 10.3791/52156.

8.

Molecular characterization of the apical organ of the anthozoan Nematostella vectensis.

Sinigaglia C, Busengdal H, Lerner A, Oliveri P, Rentzsch F.

Dev Biol. 2015 Feb 1;398(1):120-33. doi: 10.1016/j.ydbio.2014.11.019. Epub 2014 Dec 3.

9.

Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.

Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ.

J Biomed Sci. 2014 Jul 17;21:63. doi: 10.1186/s12929-014-0063-5.

10.

Murine Models of Polycystic Kidney Disease.

Menezes LF, Germino GG.

Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4):e153-e158.

11.

Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.

Čajánek L, Nigg EA.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2841-50. doi: 10.1073/pnas.1401777111. Epub 2014 Jun 30.

12.

"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases.

Meirelles GV, Perez AM, de Souza EE, Basei FL, Papa PF, Melo Hanchuk TD, Cardoso VB, Kobarg J.

World J Biol Chem. 2014 May 26;5(2):141-60. doi: 10.4331/wjbc.v5.i2.141. Review.

13.

Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?

Tran PV, Sharma M, Li X, Calvet JP.

Birth Defects Res C Embryo Today. 2014 Jun;102(2):159-73. doi: 10.1002/bdrc.21065. Epub 2014 May 26. Review.

14.

Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.

Tran PV, Talbott GC, Turbe-Doan A, Jacobs DT, Schonfeld MP, Silva LM, Chatterjee A, Prysak M, Allard BA, Beier DR.

J Am Soc Nephrol. 2014 Oct;25(10):2201-12. doi: 10.1681/ASN.2013070735. Epub 2014 Apr 3.

15.

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.

Mol Cell. 2013 Aug 22;51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.

16.

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.

Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS.

Nat Genet. 2013 Aug;45(8):951-6. doi: 10.1038/ng.2681. Epub 2013 Jun 23.

17.

Genetic background of nonmutant Piebald-Virol-Glaxo rats does not influence nephronophthisis phenotypes.

Yengkopiong JP, Lako JD.

Int J Nephrol Renovasc Dis. 2013;6:39-46. doi: 10.2147/IJNRD.S39295. Epub 2013 Feb 18.

18.
19.

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.

J Am Soc Nephrol. 2013 Jan;24(1):100-12. doi: 10.1681/ASN.2012050490.

20.

Cell cycle regulation by the NEK family of protein kinases.

Fry AM, O'Regan L, Sabir SR, Bayliss R.

J Cell Sci. 2012 Oct 1;125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review.

Items per page

Supplemental Content

Write to the Help Desk