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Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases.

Subramanian H, Gupta K, Ali H.

J Allergy Clin Immunol. 2016 Sep;138(3):700-10. doi: 10.1016/j.jaci.2016.04.051. Epub 2016 Jul 20. Review.


Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism.

Liu X, Wang J, Zhang H, Zhan M, Chen H, Fang Z, Xu C, Chen H, He S.

Mediators Inflamm. 2016;2016:6431574. doi: 10.1155/2016/6431574. Epub 2016 Jun 9.


Risk of Migraine in Patients With Asthma: A Nationwide Cohort Study.

Peng YH, Chen KF, Kao CH, Chen HJ, Hsia TC, Chen CH, Liao WC.

Medicine (Baltimore). 2016 Mar;95(9):e2911. doi: 10.1097/MD.0000000000002911.


miRNA-221-3p Enhances the Secretion of Interleukin-4 in Mast Cells through the Phosphatase and Tensin Homolog/p38/Nuclear Factor-kappaB Pathway.

Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, Yang J, Zhao D, Liu F.

PLoS One. 2016 Feb 22;11(2):e0148821. doi: 10.1371/journal.pone.0148821. eCollection 2016.


Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.

Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X.

Mucosal Immunol. 2016 Feb 10. doi: 10.1038/mi.2016.11. [Epub ahead of print]


Leukotriene E4 is a full functional agonist for human cysteinyl leukotriene type 1 receptor-dependent gene expression.

Foster HR, Fuerst E, Branchett W, Lee TH, Cousins DJ, Woszczek G.

Sci Rep. 2016 Feb 2;6:20461. doi: 10.1038/srep20461.


Non-specific airway hyperreactivity in asthma: a clinical correlate to … what exactly?

Borish L.

Clin Exp Allergy. 2016 Feb;46(2):189-91. doi: 10.1111/cea.12637. No abstract available.


Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease.

George L, Brightling CE.

Ther Adv Chronic Dis. 2016 Jan;7(1):34-51. doi: 10.1177/2040622315609251. Review.


Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma.

Singh SR, Sullo N, Matteis M, Spaziano G, McDonald J, Saunders R, Woodman L, Urbanek K, De Angelis A, De Palma R, Berair R, Pancholi M, Mistry V, Rossi F, Guerrini R, Calò G, D'Agostino B, Brightling CE, Lambert DG.

Br J Pharmacol. 2016 Apr;173(8):1286-301. doi: 10.1111/bph.13416. Epub 2016 Mar 6.


Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma.

Shin D, Park SH, Choi YJ, Kim YH, Antika LD, Habibah NU, Kang MK, Kang YH.

Int J Mol Sci. 2015 Dec 16;16(12):29980-95. doi: 10.3390/ijms161226218.


Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.

Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A.

PLoS One. 2015 Dec 11;10(12):e0144436. doi: 10.1371/journal.pone.0144436. eCollection 2015.


Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

Dahlin JS, Malinovschi A, Öhrvik H, Sandelin M, Janson C, Alving K, Hallgren J.

Blood. 2016 Jan 28;127(4):383-91. doi: 10.1182/blood-2015-06-650648. Epub 2015 Dec 1.


Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors.

Lewis RJ, Chachi L, Newby C, Amrani Y, Bradding P.

J Immunol. 2016 Jan 1;196(1):55-63. doi: 10.4049/jimmunol.1402232. Epub 2015 Nov 25.


Cough hypersensitivity as a neuro-immune interaction.

Song WJ, Chang YS.

Clin Transl Allergy. 2015 Jul 15;5:24. doi: 10.1186/s13601-015-0069-4. eCollection 2015. Review.


Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells.

Gough KC, Maddison BC, Shikotra A, Moiseeva EP, Yang W, Jarvis S, Bradding P.

Respir Res. 2015 Jul 15;16:86. doi: 10.1186/s12931-015-0245-z.


The Three A's in Asthma - Airway Smooth Muscle, Airway Remodeling & Angiogenesis.

Keglowich LF, Borger P.

Open Respir Med J. 2015 Jun 17;9:70-80. doi: 10.2174/1874306401509010070. eCollection 2015.


Single-cell analysis of mast cell degranulation induced by airway smooth muscle-secreted chemokines.

Manning BM, Meyer AF, Gruba SM, Haynes CL.

Biochim Biophys Acta. 2015 Sep;1850(9):1862-8. doi: 10.1016/j.bbagen.2015.05.008. Epub 2015 May 15.


Mast cells in airway diseases and interstitial lung disease.

Cruse G, Bradding P.

Eur J Pharmacol. 2016 May 5;778:125-38. doi: 10.1016/j.ejphar.2015.04.046. Epub 2015 May 8. Review.


Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease.

Pothoven KL, Norton JE, Hulse KE, Suh LA, Carter RG, Rocci E, Harris KE, Shintani-Smith S, Conley DB, Chandra RK, Liu MC, Kato A, Gonsalves N, Grammer LC 3rd, Peters AT, Kern RC, Bryce PJ, Tan BK, Schleimer RP.

J Allergy Clin Immunol. 2015 Sep;136(3):737-746.e4. doi: 10.1016/j.jaci.2015.01.043. Epub 2015 Apr 1.


Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms.

Hinks TS, Zhou X, Staples KJ, Dimitrov BD, Manta A, Petrossian T, Lum PY, Smith CG, Ward JA, Howarth PH, Walls AF, Gadola SD, Djukanović R.

J Allergy Clin Immunol. 2015 Aug;136(2):323-33. doi: 10.1016/j.jaci.2015.01.014. Epub 2015 Mar 5.

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