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Results: 1 to 20 of 29

1.

Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain.

Zhou XL, Yu LN, Wang Y, Tang LH, Peng YN, Cao JL, Yan M.

Mol Pain. 2014 Aug 13;10:51. doi: 10.1186/1744-8069-10-51.

PMID:
25118039
[PubMed - in process]
Free PMC Article
2.

Dopamine D₄ receptor counteracts morphine-induced changes in µ opioid receptor signaling in the striosomes of the rat caudate putamen.

Suárez-Boomgaard D, Gago B, Valderrama-Carvajal A, Roales-Buján R, Craenenbroeck KV, Duchou J, Borroto-Escuela DO, Medina-Luque J, de la Calle A, Fuxe K, Rivera A.

Int J Mol Sci. 2014 Jan 21;15(1):1481-98. doi: 10.3390/ijms15011481.

PMID:
24451133
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Epigenetics: a promising paradigm for better understanding and managing pain.

Seo S, Grzenda A, Lomberk G, Ou XM, Cruciani RA, Urrutia R.

J Pain. 2013 Jun;14(6):549-57. doi: 10.1016/j.jpain.2013.01.772. Epub 2013 Apr 19. Review.

PMID:
23602266
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Let-7 microRNAs and Opioid Tolerance.

He Y, Wang ZJ.

Front Genet. 2012 Jun 21;3:110. doi: 10.3389/fgene.2012.00110. eCollection 2012.

PMID:
22737161
[PubMed]
Free PMC Article
5.

Ligand-directed signalling within the opioid receptor family.

Pradhan AA, Smith ML, Kieffer BL, Evans CJ.

Br J Pharmacol. 2012 Nov;167(5):960-9. doi: 10.1111/j.1476-5381.2012.02075.x. Review.

PMID:
22708627
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors.

Stavitskaya L, Shim J, Healy JR, Matsumoto RR, MacKerell AD Jr, Coop A.

Bioorg Med Chem. 2012 Jul 15;20(14):4556-63. doi: 10.1016/j.bmc.2012.05.006. Epub 2012 May 11.

PMID:
22677527
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance.

Zhao J, Xin X, Xie GX, Palmer PP, Huang YG.

Mol Pain. 2012 May 21;8:38. doi: 10.1186/1744-8069-8-38. Review.

PMID:
22612909
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418.

Wen Q, Yu G, Li YL, Yan LD, Gong ZH.

Acta Pharmacol Sin. 2011 Oct;32(10):1215-24. doi: 10.1038/aps.2011.83. Epub 2011 Aug 22.

PMID:
21863064
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives.

Stavitskaya L, Coop A.

Mini Rev Med Chem. 2011 Oct;11(12):1002-8. Review.

PMID:
21861811
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.

Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T.

Addict Biol. 2013 Jul;18(4):614-22. doi: 10.1111/j.1369-1600.2011.00354.x. Epub 2011 Aug 4.

PMID:
21812868
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.

Elhabazi K, Trigo JM, Mollereau C, Moulédous L, Zajac JM, Bihel F, Schmitt M, Bourguignon JJ, Meziane H, Petit-demoulière B, Bockel F, Maldonado R, Simonin F.

Br J Pharmacol. 2012 Jan;165(2):424-35. doi: 10.1111/j.1476-5381.2011.01563.x.

PMID:
21718302
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Consensus 3D model of μ-opioid receptor ligand efficacy based on a quantitative Conformationally Sampled Pharmacophore.

Shim J, Coop A, MacKerell AD Jr.

J Phys Chem B. 2011 Jun 9;115(22):7487-96. doi: 10.1021/jp202542g. Epub 2011 May 12.

PMID:
21563754
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.

Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT.

J Neurosci. 2011 Mar 23;31(12):4434-43. doi: 10.1523/JNEUROSCI.4874-10.2011.

PMID:
21430144
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

Pradhan AA, Walwyn W, Nozaki C, Filliol D, Erbs E, Matifas A, Evans C, Kieffer BL.

J Neurosci. 2010 Dec 8;30(49):16459-68. doi: 10.1523/JNEUROSCI.3748-10.2010.

PMID:
21147985
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance.

Mercer SL, Coop A.

Curr Top Med Chem. 2011;11(9):1157-64. Review.

PMID:
21050174
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Regulation of opioid tolerance by let-7 family microRNA targeting the mu opioid receptor.

He Y, Yang C, Kirkmire CM, Wang ZJ.

J Neurosci. 2010 Jul 28;30(30):10251-8. doi: 10.1523/JNEUROSCI.2419-10.2010.

PMID:
20668208
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells.

Hwang CK, Kim CS, Kim do K, Law PY, Wei LN, Loh HH.

Mol Pharmacol. 2010 Jul;78(1):58-68. doi: 10.1124/mol.110.064311. Epub 2010 Apr 12.

PMID:
20385708
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

In vivo delta opioid receptor internalization controls behavioral effects of agonists.

Pradhan AA, Becker JA, Scherrer G, Tryoen-Toth P, Filliol D, Matifas A, Massotte D, Gavériaux-Ruff C, Kieffer BL.

PLoS One. 2009;4(5):e5425. doi: 10.1371/journal.pone.0005425. Epub 2009 May 1.

PMID:
19412545
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Effects of trichostatin A on neuronal mu-opioid receptor gene expression.

Lin YC, Flock KE, Cook RJ, Hunkele AJ, Loh HH, Ko JL.

Brain Res. 2008 Dec 30;1246:1-10. doi: 10.1016/j.brainres.2008.09.083. Epub 2008 Oct 11.

PMID:
18950606
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs.

Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A.

J Med Chem. 2008 Apr 10;51(7):2316-20. doi: 10.1021/jm701457j. Epub 2008 Feb 27.

PMID:
18311899
[PubMed - indexed for MEDLINE]
Free PMC Article

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