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Results: 19

1.

Protein Splicing: How Inteins Escape from Precursor Proteins.

Mills KV, Johnson MA, Perler FB.

J Biol Chem. 2014 May 23;289(21):14498-14505. Epub 2014 Apr 2. Review.

PMID:
24695729
[PubMed - as supplied by publisher]
Free PMC Article
2.

NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein.

Oeemig JS, Zhou D, Kajander T, Wlodawer A, Iwaï H.

J Mol Biol. 2012 Aug 3;421(1):85-99. doi: 10.1016/j.jmb.2012.04.029. Epub 2012 May 2.

PMID:
22560994
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Intramolecular disulfide bond between catalytic cysteines in an intein precursor.

Chen W, Li L, Du Z, Liu J, Reitter JN, Mills KV, Linhardt RJ, Wang C.

J Am Chem Soc. 2012 Feb 8;134(5):2500-3. doi: 10.1021/ja211010g. Epub 2012 Jan 27.

PMID:
22280304
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Branched intermediate formation is the slowest step in the protein splicing reaction of the Ala1 KlbA intein from Methanococcus jannaschii.

Saleh L, Southworth MW, Considine N, O'Neill C, Benner J, Bollinger JM Jr, Perler FB.

Biochemistry. 2011 Dec 13;50(49):10576-89. doi: 10.1021/bi200810j. Epub 2011 Nov 16.

PMID:
22026921
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structural and mutational studies of a hyperthermophilic intein from DNA polymerase II of Pyrococcus abyssi.

Du Z, Liu J, Albracht CD, Hsu A, Chen W, Marieni MD, Colelli KM, Williams JE, Reitter JN, Mills KV, Wang C.

J Biol Chem. 2011 Nov 4;286(44):38638-48. doi: 10.1074/jbc.M111.290569. Epub 2011 Sep 13.

PMID:
21914805
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

pK(a) coupling at the intein active site: implications for the coordination mechanism of protein splicing with a conserved aspartate.

Du Z, Zheng Y, Patterson M, Liu Y, Wang C.

J Am Chem Soc. 2011 Jul 6;133(26):10275-82. doi: 10.1021/ja203209f. Epub 2011 Jun 9.

PMID:
21604815
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein.

Lyskowski A, Oeemig JS, Jaakkonen A, Rommi K, DiMaio F, Zhou D, Kajander T, Baker D, Wlodawer A, Goldman A, Iwaï H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):623-6. doi: 10.1107/S1744309111008372. Epub 2011 Apr 28.

PMID:
21543876
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Electronic structure of neighboring extein residue modulates intein C-terminal cleavage activity.

Shemella PT, Topilina NI, Soga I, Pereira B, Belfort G, Belfort M, Nayak SK.

Biophys J. 2011 May 4;100(9):2217-25. doi: 10.1016/j.bpj.2011.02.037.

PMID:
21539790
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Expanding the definition of class 3 inteins and their proposed phage origin.

Tori K, Perler FB.

J Bacteriol. 2011 Apr;193(8):2035-41. doi: 10.1128/JB.01407-10. Epub 2011 Feb 11.

PMID:
21317331
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The Deinococcus radiodurans Snf2 intein caught in the act: detection of the Class 3 intein signature Block F branched intermediate.

Brace LE, Southworth MW, Tori K, Cushing ML, Perler F.

Protein Sci. 2010 Aug;19(8):1525-33. doi: 10.1002/pro.431.

PMID:
20521254
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Branched intermediate formation stimulates peptide bond cleavage in protein splicing.

Frutos S, Goger M, Giovani B, Cowburn D, Muir TW.

Nat Chem Biol. 2010 Jul;6(7):527-33. doi: 10.1038/nchembio.371. Epub 2010 May 23.

PMID:
20495572
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Splicing of the mycobacteriophage Bethlehem DnaB intein: identification of a new mechanistic class of inteins that contain an obligate block F nucleophile.

Tori K, Dassa B, Johnson MA, Southworth MW, Brace LE, Ishino Y, Pietrokovski S, Perler FB.

J Biol Chem. 2010 Jan 22;285(4):2515-26. doi: 10.1074/jbc.M109.069567. Epub 2009 Nov 22.

PMID:
19940146
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Reflections on protein splicing: structures, functions and mechanisms.

Anraku Y, Satow Y.

Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(9):409-21. Review.

PMID:
19907126
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Highly conserved histidine plays a dual catalytic role in protein splicing: a pKa shift mechanism.

Du Z, Shemella PT, Liu Y, McCallum SA, Pereira B, Nayak SK, Belfort G, Belfort M, Wang C.

J Am Chem Soc. 2009 Aug 19;131(32):11581-9. doi: 10.1021/ja904318w.

PMID:
19630416
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

NMR structure of a KlbA intein precursor from Methanococcus jannaschii.

Johnson MA, Southworth MW, Herrmann T, Brace L, Perler FB, Wüthrich K.

Protein Sci. 2007 Jul;16(7):1316-28.

PMID:
17586768
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mechanism for intein C-terminal cleavage: a proposal from quantum mechanical calculations.

Shemella P, Pereira B, Zhang Y, Van Roey P, Belfort G, Garde S, Nayak SK.

Biophys J. 2007 Feb 1;92(3):847-53. Epub 2006 Nov 3.

PMID:
17085503
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction.

Romanelli A, Shekhtman A, Cowburn D, Muir TW.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6397-402. Epub 2004 Apr 15.

PMID:
15087498
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase.

Schmitzberger F, Kilkenny ML, Lobley CM, Webb ME, Vinkovic M, Matak-Vinkovic D, Witty M, Chirgadze DY, Smith AG, Abell C, Blundell TL.

EMBO J. 2003 Dec 1;22(23):6193-204.

PMID:
14633979
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI.

Werner E, Wende W, Pingoud A, Heinemann U.

Nucleic Acids Res. 2002 Sep 15;30(18):3962-71.

PMID:
12235380
[PubMed - indexed for MEDLINE]
Free PMC Article

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