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Items: 1 to 20 of 61


Modeling the interplay between the HIF-1 and p53 pathways in hypoxia.

Zhou CH, Zhang XP, Liu F, Wang W.

Sci Rep. 2015 Sep 8;5:13834. doi: 10.1038/srep13834.


Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.

Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM.

J Clin Invest. 2015 Jun;125(6):2385-98. doi: 10.1172/JCI80402. Epub 2015 May 11.


Tumor suppressor p53 stole the AKT in hypoxia.

Yun Z, Glazer PM.

J Clin Invest. 2015 Jun;125(6):2264-6. doi: 10.1172/JCI82058. Epub 2015 May 11.


Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment.

Scanlon SE, Glazer PM.

DNA Repair (Amst). 2015 Aug;32:180-9. doi: 10.1016/j.dnarep.2015.04.030. Epub 2015 May 1.


Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells.

Timani KA, Liu Y, Fan Y, Mohammad KS, He JJ.

Mol Cell Biol. 2015 Jul;35(13):2254-64. doi: 10.1128/MCB.00001-15. Epub 2015 May 4.


Targeting lung cancer through inhibition of checkpoint kinases.

Syljuåsen RG, Hasvold G, Hauge S, Helland Å.

Front Genet. 2015 Feb 27;6:70. doi: 10.3389/fgene.2015.00070. eCollection 2015.


Neurotoxin-induced DNA damage is persistent in SH-SY5Y cells and LC neurons.

Wang Y, Musich PR, Cui K, Zou Y, Zhu MY.

Neurotox Res. 2015 May;27(4):368-83. doi: 10.1007/s12640-015-9521-4. Epub 2015 Mar 1.


Battle against cancer: an everlasting saga of p53.

Hao Q, Cho WC.

Int J Mol Sci. 2014 Dec 1;15(12):22109-27. doi: 10.3390/ijms151222109. Review.


The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.

Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J.

Front Oncol. 2014 May 19;4:96. doi: 10.3389/fonc.2014.00096. eCollection 2014. Review.


Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

Scanlon SE, Glazer PM.

Mol Cancer Res. 2014 Jul;12(7):1016-28. doi: 10.1158/1541-7786.MCR-13-0628. Epub 2014 Mar 31.


Tumor hypoxia as a driving force in genetic instability.

Luoto KR, Kumareswaran R, Bristow RG.

Genome Integr. 2013 Oct 24;4(1):5. doi: 10.1186/2041-9414-4-5.


Effects of DSP4 on the noradrenergic phenotypes and its potential molecular mechanisms in SH-SY5Y cells.

Wang Y, Musich PR, Serrano MA, Zou Y, Zhang J, Zhu MY.

Neurotox Res. 2014 Feb;25(2):193-207. doi: 10.1007/s12640-013-9421-4. Epub 2013 Aug 31.


Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.

Obacz J, Pastorekova S, Vojtesek B, Hrstka R.

Mol Cancer. 2013 Aug 14;12(1):93. doi: 10.1186/1476-4598-12-93. Review.


Hypoxia: a master regulator of microRNA biogenesis and activity.

Nallamshetty S, Chan SY, Loscalzo J.

Free Radic Biol Med. 2013 Sep;64:20-30. doi: 10.1016/j.freeradbiomed.2013.05.022. Epub 2013 May 24. Review.


Roles of Chk1 in cell biology and cancer therapy.

Zhang Y, Hunter T.

Int J Cancer. 2014 Mar 1;134(5):1013-23. doi: 10.1002/ijc.28226. Epub 2013 May 28. Review.


A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication.

Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL.

Sci Signal. 2013 Feb 12;6(262):ra10. doi: 10.1126/scisignal.2003417.


Mechanisms of chemoresistance in cancer stem cells.

Abdullah LN, Chow EK.

Clin Transl Med. 2013 Jan 17;2(1):3. doi: 10.1186/2001-1326-2-3.


Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.

Zhang T, Sentman CL.

J Immunol. 2013 Mar 1;190(5):2455-63. doi: 10.4049/jimmunol.1201314. Epub 2013 Jan 25.


Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

Pires IM, Olcina MM, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM.

Br J Cancer. 2012 Jul 10;107(2):291-9. doi: 10.1038/bjc.2012.265. Epub 2012 Jun 19.


Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.

Lee JH, Jin Y, He G, Zeng SX, Wang YV, Wahl GM, Lu H.

J Biol Chem. 2012 Jun 15;287(25):20898-903. doi: 10.1074/jbc.M111.336875. Epub 2012 May 3.

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