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Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.

Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A.

J Neurosci. 2016 Jan 13;36(2):561-76. doi: 10.1523/JNEUROSCI.1964-15.2016.


Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons.

Mostafa HH, van Loben Sels JM, Davido DJ.

J Virol. 2015 May;89(9):5171-5. doi: 10.1128/JVI.00106-15. Epub 2015 Feb 18.


The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.

Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, Herrup K, Zhang YW, Bu G, Xu H, Zhang J.

J Neurosci. 2015 Feb 11;35(6):2624-35. doi: 10.1523/JNEUROSCI.3051-14.2015.


Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.

Neves-Carvalho A, Logarinho E, Freitas A, Duarte-Silva S, Costa Mdo C, Silva-Fernandes A, Martins M, Serra SC, Lopes AT, Paulson HL, Heutink P, Relvas JB, Maciel P.

Hum Mol Genet. 2015 Jan 1;24(1):100-17. doi: 10.1093/hmg/ddu422. Epub 2014 Aug 20.


Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPAR╬│ agonist improves neuronal loss and early lethality.

Utreras E, Hamada R, Prochazkova M, Terse A, Takahashi S, Ohshima T, Kulkarni AB.

J Neuroinflammation. 2014 Feb 5;11:28. doi: 10.1186/1742-2094-11-28.


Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.

Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, Meda P, Haefliger JA.

PLoS One. 2012;7(9):e45844. doi: 10.1371/journal.pone.0045844. Epub 2012 Sep 20.


Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons.

Modi PK, Komaravelli N, Singh N, Sharma P.

Mol Biol Cell. 2012 Sep;23(18):3722-30. doi: 10.1091/mbc.E12-02-0125. Epub 2012 Jul 25.


Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance.

Ambrosini G, Pratilas CA, Qin LX, Tadi M, Surriga O, Carvajal RD, Schwartz GK.

Clin Cancer Res. 2012 Jul 1;18(13):3552-61. doi: 10.1158/1078-0432.CCR-11-3086. Epub 2012 May 1.


Transforming growth factor-╬▓1 regulates Cdk5 activity in primary sensory neurons.

Utreras E, Keller J, Terse A, Prochazkova M, Iadarola MJ, Kulkarni AB.

J Biol Chem. 2012 May 11;287(20):16917-29. doi: 10.1074/jbc.M111.329979. Epub 2012 Mar 28.


Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.

Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH 2nd, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG.

Mol Biol Cell. 2011 Dec;22(23):4683-93. doi: 10.1091/mbc.E11-06-0504. Epub 2011 Oct 5.


Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.

Chi X, Amet T, Byrd D, Chang KH, Shah K, Hu N, Grantham A, Hu S, Duan J, Tao F, Nicol G, Yu Q.

PLoS One. 2011;6(9):e24412. doi: 10.1371/journal.pone.0024412. Epub 2011 Sep 2.


Cdk5: mediator of neuronal development, death and the response to DNA damage.

Zhu J, Li W, Mao Z.

Mech Ageing Dev. 2011 Aug;132(8-9):389-94. doi: 10.1016/j.mad.2011.04.011. Epub 2011 May 11. Review.


Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.

Zheng YL, Li BS, Rudrabhatla P, Shukla V, Amin ND, Maric D, Kesavapany S, Kanungo J, Pareek TK, Takahashi S, Grant P, Kulkarni AB, Pant HC.

Mol Biol Cell. 2010 Oct 15;21(20):3601-14. doi: 10.1091/mbc.E10-01-0054. Epub 2010 Sep 1.


Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation.

Zhang J, Li H, Herrup K.

J Biol Chem. 2010 Apr 30;285(18):14052-61. doi: 10.1074/jbc.M109.068262. Epub 2010 Feb 26.


Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.

Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB.

Am J Pathol. 2010 Jan;176(1):320-9. doi: 10.2353/ajpath.2010.081158. Epub 2009 Nov 30.


Activation of cyclin-dependent kinase 5 is a consequence of cell death.

Ye Y, Tinari A, Malorni W, Lockshin RA, Zakeri Z.

J Biomed Biotechnol. 2009;2009:805709. doi: 10.1155/2009/805709. Epub 2009 Oct 8.


Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

Rashidian J, Rousseaux MW, Venderova K, Qu D, Callaghan SM, Phillips M, Bland RJ, During MJ, Mao Z, Slack RS, Park DS.

J Neurosci. 2009 Oct 7;29(40):12497-505. doi: 10.1523/JNEUROSCI.3892-09.2009.


Making a neuron: Cdk5 in embryonic and adult neurogenesis.

Jessberger S, Gage FH, Eisch AJ, Lagace DC.

Trends Neurosci. 2009 Nov;32(11):575-82. doi: 10.1016/j.tins.2009.07.002. Epub 2009 Sep 24. Review.


Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator.

Endo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga S.

J Biol Chem. 2009 Sep 18;284(38):26029-39. doi: 10.1074/jbc.M109.026443. Epub 2009 Jul 28.

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