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Items: 14

1.

Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis.

Li S, Samardzija M, Yang Z, Grimm C, Jin M.

J Neurosci. 2016 May 25;36(21):5808-19. doi: 10.1523/JNEUROSCI.3857-15.2016.

PMID:
27225770
2.

Outer Segment Thickness Predicts Visual Field Response to QLT091001 in Patients with RPE65 or LRAT Mutations.

Wen Y, Birch DG.

Transl Vis Sci Technol. 2015 Oct 1;4(5):8. eCollection 2015 Oct.

3.

Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis.

Ye L, Yu T, Li Y, Chen B, Zhang J, Wen Z, Zhang B, Zhou X, Li X, Li F, Cao W, Huang Z.

Oxid Med Cell Longev. 2013;2013:413024. doi: 10.1155/2013/413024. Epub 2013 Sep 25.

4.

Novel RPE65 mutations associated with Leber congenital amaurosis in Chinese patients.

Xu F, Dong Q, Liu L, Li H, Liang X, Jiang R, Sui R, Dong F.

Mol Vis. 2012;18:744-50. Epub 2012 Mar 28.

5.

The retinal pigment epithelium in health and disease.

Sparrow JR, Hicks D, Hamel CP.

Curr Mol Med. 2010 Dec;10(9):802-23. Review.

6.

Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.

Cideciyan AV.

Prog Retin Eye Res. 2010 Sep;29(5):398-427. doi: 10.1016/j.preteyeres.2010.04.002. Epub 2010 Apr 24. Review.

7.

An analysis of retinal gene therapy clinical trials.

MacLaren RE.

Curr Opin Mol Ther. 2009 Oct;11(5):540-6. Review.

8.

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial.

Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG.

Hum Gene Ther. 2008 Oct;19(10):979-90. doi: 10.1089/hum.2008.107.

9.

Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.

Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1126-35. doi: 10.1167/iovs.07-1234.

10.

Retinoid processing in cone and Müller cell lines.

Kanan Y, Kasus-Jacobi A, Moiseyev G, Sawyer K, Ma JX, Al-Ubaidi MR.

Exp Eye Res. 2008 Feb;86(2):344-54. doi: 10.1016/j.exer.2007.11.006. Epub 2007 Nov 17.

11.

Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.

Jin M, Yuan Q, Li S, Travis GH.

J Biol Chem. 2007 Jul 20;282(29):20915-24. Epub 2007 May 15.

12.

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

Redmond TM, Poliakov E, Yu S, Tsai JY, Lu Z, Gentleman S.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13658-63. Epub 2005 Sep 6.

13.

Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice.

Fan J, Woodruff ML, Cilluffo MC, Crouch RK, Fain GL.

J Physiol. 2005 Oct 1;568(Pt 1):83-95. Epub 2005 Jul 1.

14.

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success.

Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6177-82. Epub 2005 Apr 18.

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