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Items: 17


Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo.

Joel M, Mughal AA, Grieg Z, Murrell W, Palmero S, Mikkelsen B, Fjerdingstad HB, Sandberg CJ, Behnan J, Glover JC, Langmoen IA, Stangeland B.

Mol Cancer. 2015 Jun 17;14:121. doi: 10.1186/s12943-015-0398-x.


TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer.

Sun H, Zhang L, Shi C, Hu P, Yan W, Wang Z, Duan Q, Lu F, Qin L, Lu T, Xiao J, Wang Y, Zhu F, Shao C.

Oncotarget. 2015 May 20;6(14):12392-404.


Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins.

Rizkallah R, Batsomboon P, Dudley GB, Hurt MM.

Oncotarget. 2015 Jan 30;6(3):1446-61.


Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.

Luo Q, Lei B, Liu S, Chen Y, Sheng W, Lin P, Li W, Zhu H, Shen H.

Int J Clin Exp Pathol. 2014 Oct 15;7(11):8059-64. eCollection 2014.


TOPK and PTEN participate in CHFR mediated mitotic checkpoint.

Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S.

Cell Signal. 2013 Dec;25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3.


Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells.

Wang WQ, Li R, Bai QX, Liu YH, Zhang WP, Wang JH, Wang Z, Li YF, Chen XQ, Huang GS.

Int J Biomed Sci. 2006 Dec;2(4):395-401.


Phosphorylation of IκBα at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells.

Park JH, Yoon DS, Choi HJ, Hahm DH, Oh SM.

J Biol Chem. 2013 Feb 1;288(5):3585-93. doi: 10.1074/jbc.M112.422170. Epub 2012 Dec 17.


Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer.

Johnson C, Han Y, Hughart N, McCarra J, Alpini G, Meng F.

Transl Gastrointest Cancer. 2012 Apr 1;1(1):58-70.


A porcine gene, PBK, differentially expressed in the longissimus muscle from Meishan and Large White pig.

Yonggang L, Sumei Z, Hongbin P, Shizheng G.

Genet Mol Biol. 2009 Oct;32(4):771-5. doi: 10.1590/S1415-47572009000400017. Epub 2009 Dec 1.


Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK.

Kang NJ, Lee KW, Kim BH, Bode AM, Lee HJ, Heo YS, Boardman L, Limburg P, Lee HJ, Dong Z.

Carcinogenesis. 2011 Jun;32(6):921-8. doi: 10.1093/carcin/bgr022. Epub 2011 Feb 11.


T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.

Zykova TA, Zhu F, Vakorina TI, Zhang J, Higgins LA, Urusova DV, Bode AM, Dong Z.

J Biol Chem. 2010 Sep 17;285(38):29138-46. doi: 10.1074/jbc.M110.135905. Epub 2010 Jul 20.


Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.

Zlobec I, Molinari F, Kovac M, Bihl MP, Altermatt HJ, Diebold J, Frick H, Germer M, Horcic M, Montani M, Singer G, Yurtsever H, Zettl A, Terracciano L, Mazzucchelli L, Saletti P, Frattini M, Heinimann K, Lugli A.

Br J Cancer. 2010 Jan 5;102(1):151-61. doi: 10.1038/sj.bjc.6605452. Epub 2009 Nov 24.


Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.

Herrero-Martín D, Osuna D, Ordóñez JL, Sevillano V, Martins AS, Mackintosh C, Campos M, Madoz-Gúrpide J, Otero-Motta AP, Caballero G, Amaral AT, Wai DH, Braun Y, Eisenacher M, Schaefer KL, Poremba C, de Alava E.

Br J Cancer. 2009 Jul 7;101(1):80-90. doi: 10.1038/sj.bjc.6605104. Epub 2009 Jun 2.


Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate.

Hansel DE, Nakayama M, Luo J, Abukhdeir AM, Park BH, Bieberich CJ, Hicks JL, Eisenberger M, Nelson WG, Mostwin JL, De Marzo AM.

Prostate. 2009 May 1;69(6):603-9. doi: 10.1002/pros.20910.


The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.

Regenbrecht CR, Jung M, Lehrach H, Adjaye J.

BMC Med Genomics. 2008 Oct 10;1:49. doi: 10.1186/1755-8794-1-49.


Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.

Zykova TA, Zhu F, Lu C, Higgins L, Tatsumi Y, Abe Y, Bode AM, Dong Z.

Clin Cancer Res. 2006 Dec 1;12(23):6884-93.

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