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Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES.

Blood. 2016 Aug 4;128(5):721-31. doi: 10.1182/blood-2015-11-680280. Epub 2016 Jun 1.


Comparative Assessment of the Anticoagulant Activity of Rivaroxaban and Dabigatran in Patients With Nonvalvular Atrial Fibrillation: A Noninterventional Study.

Tsantes AE, Kyriakou E, Ikonomidis I, Katogiannis K, Papadakis I, Douramani P, Kopterides P, Kapsimali V, Lekakis J, Tsangaris I, Bonovas S.

Medicine (Baltimore). 2016 Apr;95(14):e3037. doi: 10.1097/MD.0000000000003037.


Platelets and their role in cancer evolution and immune system.

Karachaliou N, Pilotto S, Bria E, Rosell R.

Transl Lung Cancer Res. 2015 Dec;4(6):713-20. doi: 10.3978/j.issn.2218-6751.2015.10.09. Review. Retraction in: Transl Lung Cancer Res. 2016 Apr;5(2):213.


G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling.

Dolatshad NF, Hellen N, Jabbour RJ, Harding SE, Földes G.

Front Cell Dev Biol. 2015 Dec 9;3:76. doi: 10.3389/fcell.2015.00076. eCollection 2015. Review.


Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation.

Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X.

Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387. Epub 2015 Nov 19.


Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis.

Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H.

J Biomed Res. 2015 Oct 30;29. doi: 10.7555/JBR.29.20150121. [Epub ahead of print]


Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.

Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H.

Blood. 2015 Nov 19;126(21):2415-23. doi: 10.1182/blood-2015-05-644401. Epub 2015 Sep 4.


Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA.

Blood. 2015 Oct 8;126(15):1835-43. doi: 10.1182/blood-2014-09-598656. Epub 2015 Jul 15.


Thrombin regulation of synaptic transmission and plasticity: implications for health and disease.

Ben Shimon M, Lenz M, Ikenberg B, Becker D, Shavit Stein E, Chapman J, Tanne D, Pick CG, Blatt I, Neufeld M, Vlachos A, Maggio N.

Front Cell Neurosci. 2015 Apr 21;9:151. doi: 10.3389/fncel.2015.00151. eCollection 2015. Review.


A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development.

Ellery PE, Maroney SA, Cooley BC, Luyendyk JP, Zogg M, Weiler H, Mast AE.

Blood. 2015 Jun 25;125(26):4078-84. doi: 10.1182/blood-2015-03-633958. Epub 2015 May 7.


Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.

Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP.

Front Immunol. 2015 Feb 13;6:48. doi: 10.3389/fimmu.2015.00048. eCollection 2015. Review.


EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H.

Blood. 2015 Apr 30;125(18):2845-54. doi: 10.1182/blood-2014-11-610717. Epub 2015 Mar 2.


Survival advantage of heterozygous factor V Leiden carriers in murine sepsis.

Kerschen E, Hernandez I, Zogg M, Maas M, Weiler H.

J Thromb Haemost. 2015 Jun;13(6):1073-80. doi: 10.1111/jth.12876. Epub 2015 Mar 31.


C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.

Manne BK, Badolia R, Dangelmaier CA, Kunapuli SP.

Biochem Pharmacol. 2015 Jan 15;93(2):163-70. doi: 10.1016/j.bcp.2014.11.005. Epub 2014 Nov 20.


Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.

Joshi N, Kopec AK, O'Brien KM, Towery KL, Cline-Fedewa H, Williams KJ, Copple BL, Flick MJ, Luyendyk JP.

J Thromb Haemost. 2015 Jan;13(1):57-71. doi: 10.1111/jth.12770. Epub 2014 Dec 11.


Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice.

Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2563-9. doi: 10.1161/ATVBAHA.114.304244. Epub 2014 Oct 2.


Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis.

Mumaw MM, de la Fuente M, Noble DN, Nieman MT.

J Thromb Haemost. 2014 Aug;12(8):1331-41. doi: 10.1111/jth.12619. Epub 2014 Jun 27.


Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets.

Arachiche A, de la Fuente M, Nieman MT.

PLoS One. 2014 May 15;9(5):e97724. doi: 10.1371/journal.pone.0097724. eCollection 2014.


Thrombosis, platelets, microparticles and PAH: more than a clot.

Lannan KL, Phipps RP, White RJ.

Drug Discov Today. 2014 Aug;19(8):1230-5. doi: 10.1016/j.drudis.2014.04.001. Epub 2014 Apr 18. Review.


Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.

Boulaftali Y, Hess PR, Kahn ML, Bergmeier W.

Circ Res. 2014 Mar 28;114(7):1174-84. doi: 10.1161/CIRCRESAHA.114.301611. Review.

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