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The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.

Maggio M, De Vita F, Fisichella A, Lauretani F, Ticinesi A, Ceresini G, Cappola A, Ferrucci L, Ceda GP.

Int J Endocrinol. 2015;2015:292574. doi: 10.1155/2015/292574. Epub 2015 Dec 8. Review.


Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.

Chan Y, Salem RM, Hsu YH, McMahon G, Pers TH, Vedantam S, Esko T, Guo MH, Lim ET; GIANT Consortium, Franke L, Smith GD, Strachan DP, Hirschhorn JN.

Am J Hum Genet. 2015 May 7;96(5):695-708. doi: 10.1016/j.ajhg.2015.02.018. Epub 2015 Apr 9.


Core functional sequence of C-terminal GAG-binding domain directs cellular uptake of IGFBP-3-derived peptides.

Liu D, Zhang X, Gao J, Palombo M, Gao D, Chen P, Sinko PJ.

Protein Pept Lett. 2014;21(2):124-31.


Insulin concentration is critical in culturing human neural stem cells and neurons.

Rhee YH, Choi M, Lee HS, Park CH, Kim SM, Yi SH, Oh SM, Cha HJ, Chang MY, Lee SH.

Cell Death Dis. 2013 Aug 8;4:e766. doi: 10.1038/cddis.2013.295.


Recent progress in pharmaceutical therapies for castration-resistant prostate cancer.

Yin L, Hu Q, Hartmann RW.

Int J Mol Sci. 2013 Jul 4;14(7):13958-78. doi: 10.3390/ijms140713958. Review.


Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor.

Zhang Q, Soderland C, Steinle JJ.

Apoptosis. 2013 Mar;18(3):361-8. doi: 10.1007/s10495-012-0793-3.


Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin.

Bouley R, Nunes P, Andriopoulos B Jr, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F553-64. doi: 10.1152/ajprenal.00438.2011. Epub 2012 Dec 12.


Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis.

Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine ML.

J Bone Miner Res. 2013 Mar;28(3):672-87. doi: 10.1002/jbmr.1779.


Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.

Jarajapu YP, Cai J, Yan Y, Li Calzi S, Kielczewski JL, Hu P, Shaw LC, Firth SM, Chan-Ling T, Boulton ME, Baxter RC, Grant MB.

PLoS One. 2012;7(7):e39398. doi: 10.1371/journal.pone.0039398. Epub 2012 Jul 6.


Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus.

Tran PV, Fretham SJ, Wobken J, Miller BS, Georgieff MK.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E316-24. doi: 10.1152/ajpendo.00369.2011. Epub 2011 Nov 16.


Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury.

Kielczewski JL, Hu P, Shaw LC, Li Calzi S, Mames RN, Gardiner TA, McFarland E, Chan-Ling T, Grant MB.

Am J Pathol. 2011 Apr;178(4):1517-28. doi: 10.1016/j.ajpath.2010.12.031.


Association between insulin-like growth factor binding protein-3 promoter polymorphism of -1590 C>A and lung cancer susceptibility in a Chinese Han population.

Dai X, Liu Z, Ren J, Wu G.

Genet Test Mol Biomarkers. 2011 May;15(5):301-6. doi: 10.1089/gtmb.2010.0176. Epub 2011 Jan 22.


Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis.

Williams NG, Interlichia JP, Jackson MF, Hwang D, Cohen P, Rodgers BD.

Endocrinology. 2011 Jan;152(1):172-80. doi: 10.1210/en.2010-0488. Epub 2010 Dec 8.


Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.

Ingermann AR, Yang YF, Han J, Mikami A, Garza AE, Mohanraj L, Fan L, Idowu M, Ware JL, Kim HS, Lee DY, Oh Y.

J Biol Chem. 2010 Sep 24;285(39):30233-46. doi: 10.1074/jbc.M110.122226. Epub 2010 Mar 30.


Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation.

Kielczewski JL, Jarajapu YP, McFarland EL, Cai J, Afzal A, Li Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Boulton ME, Mames RN, Chan-Ling T, Grant MB.

Circ Res. 2009 Oct 23;105(9):897-905. doi: 10.1161/CIRCRESAHA.109.199059. Epub 2009 Sep 17.


Unraveling insulin-like growth factor binding protein-3 actions in human disease.

Jogie-Brahim S, Feldman D, Oh Y.

Endocr Rev. 2009 Aug;30(5):417-37. doi: 10.1210/er.2008-0028. Epub 2009 May 28. Review.


Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2.

Lesnikov V, Gorden N, Fausto N, Spaulding E, Campbell J, Shulman H, Fleming RE, Deeg HJ.

Apoptosis. 2008 Aug;13(8):1005-12. doi: 10.1007/s10495-008-0233-6.


Intracellular iron transport and storage: from molecular mechanisms to health implications.

MacKenzie EL, Iwasaki K, Tsuji Y.

Antioxid Redox Signal. 2008 Jun;10(6):997-1030. doi: 10.1089/ars.2007.1893. Review.


Novel actions of IGFBP-3 on intracellular signaling pathways of insulin-secreting cells.

Chen X, Ferry RJ Jr.

Growth Horm IGF Res. 2006 Feb;16(1):41-8. Epub 2005 Nov 4. Erratum in: Growth Horm IGF Res. 2006 Aug;16(4):276.


Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.

Ord JJ, Streeter EH, Roberts IS, Cranston D, Harris AL.

Br J Cancer. 2005 Aug 8;93(3):346-54.

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