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Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.

Arif Pavel M, Lv C, Ng C, Yang L, Kashyap P, Lam C, Valentino V, Fung HY, Campbell T, Møller SG, Zenisek D, Holtzman NG, Yu Y.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2363-72. doi: 10.1073/pnas.1517066113. Epub 2016 Apr 11.


Role of calcium in polycystic kidney disease: From signaling to pathology.

Mangolini A, de Stephanis L, Aguiari G.

World J Nephrol. 2016 Jan 6;5(1):76-83. doi: 10.5527/wjn.v5.i1.76. Review.


An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.

Carrisoza-Gaytan R, Carattino MD, Kleyman TR, Satlin LM.

Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C243-59. doi: 10.1152/ajpcell.00328.2015. Epub 2015 Dec 2. Review.


The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR.

Roxo-Rosa M, Jacinto R, Sampaio P, Lopes SS.

Biol Open. 2015 Oct 2;4(11):1356-66. doi: 10.1242/bio.014076.


A TRPM4-dependent current in murine renal primary cilia.

Flannery RJ, Kleene NK, Kleene SJ.

Am J Physiol Renal Physiol. 2015 Oct 15;309(8):F697-707. doi: 10.1152/ajprenal.00294.2015. Epub 2015 Aug 19.


The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function.

Cantero Mdel R, Velázquez IF, Streets AJ, Ong AC, Cantiello HF.

J Biol Chem. 2015 Sep 25;290(39):23888-96. doi: 10.1074/jbc.M115.661082. Epub 2015 Aug 12.


A polycystin-centric view of cyst formation and disease: the polycystins revisited.

Ong AC, Harris PC.

Kidney Int. 2015 Oct;88(4):699-710. doi: 10.1038/ki.2015.207. Epub 2015 Jul 22. Review.


Polycystin-2 (TRPP2) Regulation by Ca(2+) Is Effected and Diversified by Actin-Binding Proteins.

Cantero Mdel R, Cantiello HF.

Biophys J. 2015 May 5;108(9):2191-200. doi: 10.1016/j.bpj.2015.03.050.


Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Saigusa T, Bell PD.

Physiology (Bethesda). 2015 May;30(3):195-207. doi: 10.1152/physiol.00032.2014. Review.


Electrical Signaling in Motile and Primary Cilia.

Kleene SJ, Van Houten JL.

Bioscience. 2014 Dec 1;64(12):1092-1102.


Vasopressin and disruption of calcium signalling in polycystic kidney disease.

Chebib FT, Sussman CR, Wang X, Harris PC, Torres VE.

Nat Rev Nephrol. 2015 Aug;11(8):451-64. doi: 10.1038/nrneph.2015.39. Epub 2015 Apr 14. Review.


Filamin-a increases the stability and plasma membrane expression of polycystin-2.

Wang Q, Zheng W, Wang Z, Yang J, Hussein S, Tang J, Chen XZ.

PLoS One. 2015 Apr 10;10(4):e0123018. doi: 10.1371/journal.pone.0123018. eCollection 2015.


Situs inversus and ciliary abnormalities: 20 years later, what is the connection?

Pennekamp P, Menchen T, Dworniczak B, Hamada H.

Cilia. 2015 Jan 14;4(1):1. doi: 10.1186/s13630-014-0010-9. eCollection 2015.


Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

Gainullin VG, Hopp K, Ward CJ, Hommerding CJ, Harris PC.

J Clin Invest. 2015 Feb;125(2):607-20. doi: 10.1172/JCI76972. Epub 2015 Jan 9.


MicroRNAs in the pathogenesis of cystic kidney disease.

Phua YL, Ho J.

Curr Opin Pediatr. 2015 Apr;27(2):219-26. doi: 10.1097/MOP.0000000000000168. Review.


Role of TRP channels in the cardiovascular system.

Yue Z, Xie J, Yu AS, Stock J, Du J, Yue L.

Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H157-82. doi: 10.1152/ajpheart.00457.2014. Epub 2014 Nov 21. Review.


The loss of taste genes in cetaceans.

Zhu K, Zhou X, Xu S, Sun D, Ren W, Zhou K, Yang G.

BMC Evol Biol. 2014 Oct 12;14:218. doi: 10.1186/s12862-014-0218-8.


Permeation, regulation and control of expression of TRP channels by trace metal ions.

Bouron A, Kiselyov K, Oberwinkler J.

Pflugers Arch. 2015 Jun;467(6):1143-64. doi: 10.1007/s00424-014-1590-3. Epub 2014 Aug 10. Review.


Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.

Harris PC, Torres VE.

J Clin Invest. 2014 Jun;124(6):2315-24. doi: 10.1172/JCI72272. Epub 2014 Jun 2. Review.


Polycystins and partners: proposed role in mechanosensitivity.

Retailleau K, Duprat F.

J Physiol. 2014 Jun 15;592(12):2453-71. doi: 10.1113/jphysiol.2014.271346. Epub 2014 Mar 31. Review.

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