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Items: 1 to 20 of 22


Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.

Free Radic Biol Med. 2015 Dec;89:1184-91. doi: 10.1016/j.freeradbiomed.2015.11.003. Epub 2015 Nov 5.


Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3.

Deevska G, Sunkara M, Karakashian C, Peppers B, Morris AJ, Nikolova-Karakashian MN.

J Lipid Res. 2014 Oct;55(10):2041-52. doi: 10.1194/jlr.M048223. Epub 2014 Jul 21.


Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.

Keith D, Finlay L, Butler J, Gómez L, Smith E, Moreau R, Hagen T.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):324-9. doi: 10.1016/j.bbrc.2014.05.112. Epub 2014 Jun 2.


NRF2 and p53: Januses in cancer?

Rotblat B, Melino G, Knight RA.

Oncotarget. 2012 Nov;3(11):1272-83. Review.


Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.

Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, Christensen JM, Pereira C, Hagen TM.

Pharmacol Res. 2012 Sep;66(3):199-206. doi: 10.1016/j.phrs.2012.05.002. Epub 2012 May 16.


Diabetes and alpha lipoic Acid.

Golbidi S, Badran M, Laher I.

Front Pharmacol. 2011 Nov 17;2:69. doi: 10.3389/fphar.2011.00069. eCollection 2011.


R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM.

Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97. doi: 10.1152/ajpregu.00393.2011. Epub 2011 Nov 2.


Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.

Salinthone S, Schillace RV, Tsang C, Regan JW, Bourdette DN, Carr DW.

J Nutr Biochem. 2011 Jul;22(7):681-90. doi: 10.1016/j.jnutbio.2010.05.008. Epub 2010 Oct 30.


Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress.

Chen H, Zhou L, Lin CY, Beattie MC, Liu J, Zirkin BR.

Mol Cell Endocrinol. 2010 Jul 29;323(2):147-54. doi: 10.1016/j.mce.2010.02.034. Epub 2010 Mar 3.


Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.

Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.

Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. doi: 10.1016/j.bbagen.2009.07.026. Epub 2009 Aug 4. Review.


Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.

Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, Gasimov E, Perry G, Ames BN.

J Cell Mol Med. 2009 Feb;13(2):320-33. doi: 10.1111/j.1582-4934.2008.00324.x. Epub 2008 Mar 28.


Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.

Smith AR, Visioli F, Frei B, Hagen TM.

Br J Pharmacol. 2008 Apr;153(8):1615-22. doi: 10.1038/bjp.2008.28. Epub 2008 Feb 25.


Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.

Dixon BM, Heath SH, Kim R, Suh JH, Hagen TM.

Antioxid Redox Signal. 2008 May;10(5):963-72. doi: 10.1089/ars.2007.1869.


Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation.

Rutkute K, Asmis RH, Nikolova-Karakashian MN.

J Lipid Res. 2007 Nov;48(11):2443-52. Epub 2007 Aug 10.


Regulation of insulin-like growth factor binding protein-1 expression during aging.

Rutkute K, Nikolova-Karakashian MN.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):263-9. Epub 2007 Jun 21.


Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):339-48.


(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage.

Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10.


Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3381-6. Epub 2004 Feb 25.


Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.

Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2356-61. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184-5.

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