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Results: 1 to 20 of 76

1.

Re-configuration of sphingolipid metabolism by oncogenic transformation.

Don AS, Lim XY, Couttas TA.

Biomolecules. 2014 Mar 14;4(1):315-53. doi: 10.3390/biom4010315.

PMID:
24970218
[PubMed]
Free PMC Article
2.

Sphingosine 1-phosphate and cancer: lessons from thyroid cancer cells.

Törnquist K.

Biomolecules. 2013 May 14;3(2):303-15. doi: 10.3390/biom3020303.

PMID:
24970169
[PubMed]
Free PMC Article
3.

Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis.

Huang WC, Nagahashi M, Terracina KP, Takabe K.

Biomolecules. 2013 Sep 1;3(3). doi: 10.3390/biom3030408.

PMID:
24286034
[PubMed]
Free PMC Article
4.

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors.

Baek DJ, MacRitchie N, Anthony NG, Mackay SP, Pyne S, Pyne NJ, Bittman R.

J Med Chem. 2013 Nov 27;56(22):9310-27. doi: 10.1021/jm401399c. Epub 2013 Nov 14.

PMID:
24164513
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers.

Pyne S, Edwards J, Ohotski J, Pyne NJ.

Front Oncol. 2012 Dec 3;2:168. doi: 10.3389/fonc.2012.00168. eCollection 2012.

PMID:
23316473
[PubMed]
Free PMC Article
6.

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.

Tonelli F, Alossaimi M, Williamson L, Tate RJ, Watson DG, Chan E, Bittman R, Pyne NJ, Pyne S.

Br J Pharmacol. 2013 Mar;168(6):1497-505. doi: 10.1111/bph.12035.

PMID:
23113536
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.

Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM.

Biochem J. 2013 Feb 1;449(3):661-72. doi: 10.1042/BJ20120213.

PMID:
23106337
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.

Aoyagi T, Nagahashi M, Yamada A, Takabe K.

Lymphat Res Biol. 2012 Sep;10(3):97-106. doi: 10.1089/lrb.2012.0010. Review.

PMID:
22984905
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.

Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM.

J Biol Chem. 2012 Sep 14;287(38):31794-803. doi: 10.1074/jbc.M112.385765. Epub 2012 Jul 24.

PMID:
22833671
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.

Orr Gandy KA, Obeid LM.

Biochim Biophys Acta. 2013 Jan;1831(1):157-66. doi: 10.1016/j.bbalip.2012.07.002. Epub 2012 Jul 16. Review.

PMID:
22801037
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B.

EMBO Mol Med. 2012 Aug;4(8):761-75. doi: 10.1002/emmm.201200244. Epub 2012 Jun 18.

PMID:
22707406
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

Gellett AM, Kharel Y, Sunkara M, Morris AJ, Lynch KR.

Biochem Biophys Res Commun. 2012 Jun 15;422(4):758-63. doi: 10.1016/j.bbrc.2012.05.077. Epub 2012 May 22.

PMID:
22627129
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer.

Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD.

Carcinogenesis. 2012 Sep;33(9):1726-35. doi: 10.1093/carcin/bgs174. Epub 2012 May 11.

PMID:
22581840
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

H-Ras increases release of sphingosine resulting in down-regulation of TSP-1 in non-transformed cells.

Kalas W, Rybka J, Swiderek E, Ziolo E, Rybka W, Gamian A, Rak J, Strzadala L.

Int J Exp Pathol. 2012 Jun;93(3):202-9. doi: 10.1111/j.1365-2613.2011.00805.x. Epub 2012 Feb 22.

PMID:
22356213
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.

Nunes J, Naymark M, Sauer L, Muhammad A, Keun H, Sturge J, Stebbing J, Waxman J, Pchejetski D.

Br J Cancer. 2012 Feb 28;106(5):909-15. doi: 10.1038/bjc.2012.14. Epub 2012 Feb 7.

PMID:
22315056
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Targeting sphingosine kinase-1 to inhibit melanoma.

Madhunapantula SV, Hengst J, Gowda R, Fox TE, Yun JK, Robertson GP.

Pigment Cell Melanoma Res. 2012 Mar;25(2):259-74. doi: 10.1111/j.1755-148X.2012.00970.x.

PMID:
22236408
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.

Lan T, Liu W, Xie X, Xu S, Huang K, Peng J, Shen X, Liu P, Wang L, Xia P, Huang H.

Mol Endocrinol. 2011 Dec;25(12):2094-105. doi: 10.1210/me.2011-0095. Epub 2011 Oct 13.

PMID:
21998146
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Effects of lysophospholipids on tumor microenvironment.

Rolin J, Maghazachi AA.

Cancer Microenviron. 2011 Dec;4(3):393-403. doi: 10.1007/s12307-011-0088-1. Epub 2011 Sep 9.

PMID:
21904916
[PubMed]
Free PMC Article
20.

Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.

Gao P, Smith CD.

Mol Cancer Res. 2011 Nov;9(11):1509-19. doi: 10.1158/1541-7786.MCR-11-0336. Epub 2011 Sep 6.

PMID:
21896638
[PubMed - indexed for MEDLINE]
Free PMC Article

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