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Combined EGFR- and notch inhibition display additive inhibitory effect on glioblastoma cell viability and glioblastoma-induced endothelial cell sprouting in vitro.

Staberg M, Michaelsen SR, Olsen LS, Nedergaard MK, Villingshøj M, Stockhausen MT, Hamerlik P, Poulsen HS.

Cancer Cell Int. 2016 Apr 26;16:34. doi: 10.1186/s12935-016-0309-2. eCollection 2016.


Notch signaling in prostate cancer: refining a therapeutic opportunity.

Su Q, Xin L.

Histol Histopathol. 2016 Feb;31(2):149-57. doi: 10.14670/HH-11-685. Epub 2015 Nov 2. Review.


AKT and 14-3-3 regulate Notch4 nuclear localization.

Ramakrishnan G, Davaakhuu G, Chung WC, Zhu H, Rana A, Filipovic A, Green AR, Atfi A, Pannuti A, Miele L, Tzivion G.

Sci Rep. 2015 Mar 5;5:8782. doi: 10.1038/srep08782.


Coordinate hyperactivation of Notch1 and Ras/MAPK pathways correlates with poor patient survival: novel therapeutic strategy for aggressive breast cancers.

Mittal S, Sharma A, Balaji SA, Gowda MC, Dighe RR, Kumar RV, Rangarajan A.

Mol Cancer Ther. 2014 Dec;13(12):3198-209. doi: 10.1158/1535-7163.MCT-14-0280. Epub 2014 Sep 24.


From fly wings to targeted cancer therapies: a centennial for notch signaling.

Ntziachristos P, Lim JS, Sage J, Aifantis I.

Cancer Cell. 2014 Mar 17;25(3):318-34. doi: 10.1016/j.ccr.2014.02.018. Review.


Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme.

El Hindy N, Keyvani K, Pagenstecher A, Dammann P, Sandalcioglu IE, Sure U, Zhu Y.

Neuro Oncol. 2013 Oct;15(10):1366-78. doi: 10.1093/neuonc/not071. Epub 2013 Jun 20.


Notch inhibitors for cancer treatment.

Espinoza I, Miele L.

Pharmacol Ther. 2013 Aug;139(2):95-110. doi: 10.1016/j.pharmthera.2013.02.003. Epub 2013 Feb 28. Review.


The different role of Notch1 and Notch2 in astrocytic gliomas.

Xu P, Zhang A, Jiang R, Qiu M, Kang C, Jia Z, Wang G, Han L, Fan X, Pu P.

PLoS One. 2013;8(1):e53654. doi: 10.1371/journal.pone.0053654. Epub 2013 Jan 21.


Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo.

Lombardo Y, Filipović A, Molyneux G, Periyasamy M, Giamas G, Hu Y, Trivedi PS, Wang J, Yagüe E, Michel L, Coombes RC.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16558-63. doi: 10.1073/pnas.1206268109. Epub 2012 Sep 24.


Tumor stem cells: A new approach for tumor therapy (Review).

Meng M, Zhao XH, Ning Q, Hou L, Xin GH, Liu LF.

Oncol Lett. 2012 Aug;4(2):187-193. Epub 2012 May 25.


Notch inhibition as a promising new approach to cancer therapy.

Purow B.

Adv Exp Med Biol. 2012;727:305-19. doi: 10.1007/978-1-4614-0899-4_23. Review.


Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.

Cook N, Frese KK, Bapiro TE, Jacobetz MA, Gopinathan A, Miller JL, Rao SS, Demuth T, Howat WJ, Jodrell DI, Tuveson DA.

J Exp Med. 2012 Mar 12;209(3):437-44. doi: 10.1084/jem.20111923. Epub 2012 Feb 20.


Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma.

Allen TD, Rodriguez EM, Jones KD, Bishop JM.

Cancer Res. 2011 Sep 15;71(18):6010-8. doi: 10.1158/0008-5472.CAN-11-0595. Epub 2011 Jul 29.


KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations.

O'Hagan RC, Heyer J.

Genes Cancer. 2011 Mar;2(3):335-43. doi: 10.1177/1947601911408080.


Novel therapeutic strategies for targeting liver cancer stem cells.

Oishi N, Wang XW.

Int J Biol Sci. 2011 Apr 26;7(5):517-35. Review.


The functional role of Notch signaling in human gliomas.

Stockhausen MT, Kristoffersen K, Poulsen HS.

Neuro Oncol. 2010 Feb;12(2):199-211. doi: 10.1093/neuonc/nop022. Epub 2009 Dec 14. Review.


Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer.

Lin L, Mernaugh R, Yi F, Blum D, Carbone DP, Dang TP.

Cancer Res. 2010 Jan 15;70(2):632-8. doi: 10.1158/0008-5472.CAN-09-3293. Epub 2010 Jan 12.


Cancer stem cells and hepatocellular carcinoma.

Yao Z, Mishra L.

Cancer Biol Ther. 2009 Sep;8(18):1691-8. Review.


Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.

Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP.

Oncogene. 2010 Jan 28;29(4):589-96. doi: 10.1038/onc.2009.366. Epub 2009 Nov 2.


PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling.

Bansal K, Kapoor N, Narayana Y, Puzo G, Gilleron M, Balaji KN.

PLoS One. 2009;4(3):e4911. doi: 10.1371/journal.pone.0004911. Epub 2009 Mar 17.

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