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High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial.

Johnson K, McEvoy CE, Naqvi S, Wendt C, Reilkoff RA, Kunisaki KM, Wetherbee EE, Nelson D, Tirouvanziam R, Niewoehner DE.

Int J Chron Obstruct Pulmon Dis. 2016 Apr 21;11:799-807. doi: 10.2147/COPD.S102375. eCollection 2016.


N-acetylcysteine in COPD: why, how, and when?

Sanguinetti CM.

Multidiscip Respir Med. 2016 Feb 3;11:8. doi: 10.1186/s40248-016-0039-2. eCollection 2015. Review.


Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes.

Zhang JQ, Zhang JQ, Liu H, Zhao ZH, Fang LZ, Liu L, Fu WP, Shu JK, Feng JG, Dai LM.

Int J Chron Obstruct Pulmon Dis. 2015 May 13;10:917-23. doi: 10.2147/COPD.S79710. eCollection 2015.


A selective review of glutamate pharmacological therapy in obsessive-compulsive and related disorders.

Grados MA, Atkins EB, Kovacikova GI, McVicar E.

Psychol Res Behav Manag. 2015 Apr 28;8:115-31. doi: 10.2147/PRBM.S58601. eCollection 2015. Review.


Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.

Apostolova N, Victor VM.

Antioxid Redox Signal. 2015 Mar 10;22(8):686-729. doi: 10.1089/ars.2014.5952. Review.


Oxidative stress and free radicals in COPD--implications and relevance for treatment.

Domej W, Oettl K, Renner W.

Int J Chron Obstruct Pulmon Dis. 2014 Oct 17;9:1207-24. doi: 10.2147/COPD.S51226. eCollection 2014. Review.


Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease.

Tse HN, Tseng CZ.

Int J Chron Obstruct Pulmon Dis. 2014 Aug 6;9:825-36. doi: 10.2147/COPD.S51057. eCollection 2014. Review.


Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine.

Santus P, Corsico A, Solidoro P, Braido F, Di Marco F, Scichilone N.

COPD. 2014 Dec;11(6):705-17. doi: 10.3109/15412555.2014.898040. Epub 2014 Apr 30. Review.


A combination of pre- and post-exposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage.

Ito Y, Kinoshita M, Yamamoto T, Sato T, Obara T, Saitoh D, Seki S, Takahashi Y.

Int J Mol Sci. 2013 Sep 27;14(10):19618-35. doi: 10.3390/ijms141019618.


Oxidative stress in asthma.

Sahiner UM, Birben E, Erzurum S, Sackesen C, Kalayci O.

World Allergy Organ J. 2011 Oct;4(10):151-8. doi: 10.1097/WOX.0b013e318232389e. Epub 2011 Oct 10.


Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine.

Mata M, Sarrion I, Armengot M, Carda C, Martinez I, Melero JA, Cortijo J.

PLoS One. 2012;7(10):e48037. doi: 10.1371/journal.pone.0048037. Epub 2012 Oct 31.


Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases.

Zhavoronkov A, Smit-McBride Z, Guinan KJ, Litovchenko M, Moskalev A.

J Mol Med (Berl). 2012 Dec;90(12):1361-89. doi: 10.1007/s00109-012-0962-4. Epub 2012 Oct 23. Review.


Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities.

Garofalo RP, Kolli D, Casola A.

Antioxid Redox Signal. 2013 Jan 10;18(2):186-217. doi: 10.1089/ars.2011.4307. Epub 2012 Sep 7. Review.


Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.

Rahman I, Kinnula VL.

Expert Rev Clin Pharmacol. 2012 May;5(3):293-309. doi: 10.1586/ecp.12.16. Review.


Antioxidant pharmacological therapies for COPD.

Rahman I, MacNee W.

Curr Opin Pharmacol. 2012 Jun;12(3):256-65. doi: 10.1016/j.coph.2012.01.015. Epub 2012 Feb 18. Review.


Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities.

Fitzpatrick AM, Jones DP, Brown LA.

Antioxid Redox Signal. 2012 Jul 15;17(2):375-408. doi: 10.1089/ars.2011.4198. Epub 2012 Mar 9. Review.


Pharmacological antioxidant strategies as therapeutic interventions for COPD.

Rahman I.

Biochim Biophys Acta. 2012 May;1822(5):714-28. doi: 10.1016/j.bbadis.2011.11.004. Epub 2011 Nov 9. Review.


Update on pharmaceutical and minimally invasive management strategies for chronic obstructive pulmonary disease.

Rafii R, Albertson TE, Louie S, Chan AL.

Pulm Med. 2011;2011:257496. doi: 10.1155/2011/257496. Epub 2011 Apr 20.

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