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Items: 8


The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.

Droppelmann CA, Campos-Melo D, Volkening K, Strong MJ.

Front Cell Neurosci. 2014 Sep 10;8:282. doi: 10.3389/fncel.2014.00282. eCollection 2014. Review.


Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation.

Reid PJ, Mohammad-Qureshi SS, Pavitt GD.

J Biol Chem. 2012 Mar 9;287(11):8275-85. doi: 10.1074/jbc.M111.331645. Epub 2012 Jan 11.


Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex.

Wang X, Wortham NC, Liu R, Proud CG.

J Biol Chem. 2012 Mar 9;287(11):8263-74. doi: 10.1074/jbc.M111.331553. Epub 2012 Jan 11.


The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.

Dev K, Qiu H, Dong J, Zhang F, Barthlme D, Hinnebusch AG.

Mol Cell Biol. 2010 Nov;30(21):5218-33. doi: 10.1128/MCB.00265-10. Epub 2010 Aug 30.


Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.

Tuckow AP, Vary TC, Kimball SR, Jefferson LS.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E241-8. doi: 10.1152/ajpendo.00151.2010. Epub 2010 May 18.

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