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Items: 1 to 20 of 39


Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol.

Mislak AC, Anderson KS.

Antimicrob Agents Chemother. 2015 Nov 9;60(1):561-9. doi: 10.1128/AAC.02270-15.


Biolayer Interferometry: A Novel Method to Elucidate Protein-Protein and Protein-DNA Interactions in the Mitochondrial DNA Replisome.

Ciesielski GL, Hytönen VP, Kaguni LS.

Methods Mol Biol. 2016;1351:223-31. doi: 10.1007/978-1-4939-3040-1_17.


POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.

Young MJ, Humble MM, DeBalsi KL, Sun KY, Copeland WC.

Hum Mol Genet. 2015 Sep 15;24(18):5184-97. doi: 10.1093/hmg/ddv240. Epub 2015 Jun 29.


Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase.

Szymanski MR, Kuznetsov VB, Shumate C, Meng Q, Lee YS, Patel G, Patel S, Yin YW.

EMBO J. 2015 Jul 14;34(14):1959-70. doi: 10.15252/embj.201591520. Epub 2015 Jun 8.


Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms.

Qian Y, Ziehr JL, Johnson KA.

Front Genet. 2015 Apr 9;6:135. doi: 10.3389/fgene.2015.00135. eCollection 2015.


Mitochondrial genome maintenance in health and disease.

Copeland WC, Longley MJ.

DNA Repair (Amst). 2014 Jul;19:190-8. doi: 10.1016/j.dnarep.2014.03.010. Epub 2014 Apr 26. Review.


Mapping 136 pathogenic mutations into functional modules in human DNA polymerase γ establishes predictive genotype-phenotype correlations for the complete spectrum of POLG syndromes.

Farnum GA, Nurminen A, Kaguni LS.

Biochim Biophys Acta. 2014 Jul;1837(7):1113-21. doi: 10.1016/j.bbabio.2014.01.021. Epub 2014 Feb 7.


Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

Feng JY, Cheng G, Perry J, Barauskas O, Xu Y, Fenaux M, Eng S, Tirunagari N, Peng B, Yu M, Tian Y, Lee YJ, Stepan G, Lagpacan LL, Jin D, Hung M, Ku KS, Han B, Kitrinos K, Perron M, Birkus G, Wong KA, Zhong W, Kim CU, Carey A, Cho A, Ray AS.

Antimicrob Agents Chemother. 2014;58(4):1930-42. doi: 10.1128/AAC.02351-13. Epub 2014 Jan 13.


Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression.

Qian Y, Kachroo AH, Yellman CM, Marcotte EM, Johnson KA.

J Biol Chem. 2014 Feb 28;289(9):5970-85. doi: 10.1074/jbc.M113.526418. Epub 2014 Jan 7.


Kinetic characterization of exonuclease-deficient Staphylococcus aureus PolC, a C-family replicative DNA polymerase.

Lahiri I, Mukherjee P, Pata JD.

PLoS One. 2013 May 16;8(5):e63489. doi: 10.1371/journal.pone.0063489. Print 2013.


Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS.

Hum Mol Genet. 2013 Mar 15;22(6):1074-85. doi: 10.1093/hmg/dds509. Epub 2012 Dec 3.


Mitochondrial DNA damage and its consequences for mitochondrial gene expression.

Cline SD.

Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):979-91. doi: 10.1016/j.bbagrm.2012.06.002. Epub 2012 Jun 19. Review.


Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.

Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS.

Mol Pharmacol. 2012 Jul;82(1):125-33. doi: 10.1124/mol.112.078758. Epub 2012 Apr 18.


C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.

Viikov K, Jasnovidova O, Tamm T, Sedman J.

PLoS One. 2012;7(3):e33482. doi: 10.1371/journal.pone.0033482. Epub 2012 Mar 14.


Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.

Song Z, Cao Y, Samuels DC.

PLoS Comput Biol. 2011 Nov;7(11):e1002287. doi: 10.1371/journal.pcbi.1002287. Epub 2011 Nov 17.


Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.

Bakthavatchalu V, Dey S, Xu Y, Noel T, Jungsuwadee P, Holley AK, Dhar SK, Batinic-Haberle I, St Clair DK.

Oncogene. 2012 Apr 26;31(17):2129-39. doi: 10.1038/onc.2011.407. Epub 2011 Sep 12.


Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity.

Estep PA, Johnson KA.

Biochemistry. 2011 Jul 26;50(29):6376-86. doi: 10.1021/bi200280r. Epub 2011 Jul 5.


Biochemical analysis of human POLG2 variants associated with mitochondrial disease.

Young MJ, Longley MJ, Li FY, Kasiviswanathan R, Wong LJ, Copeland WC.

Hum Mol Genet. 2011 Aug 1;20(15):3052-66. doi: 10.1093/hmg/ddr209. Epub 2011 May 9.


Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.

Batabyal D, McKenzie JL, Johnson KA.

J Biol Chem. 2010 Oct 29;285(44):34191-201. doi: 10.1074/jbc.M110.156182. Epub 2010 Aug 3.


A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.

Anderson KS.

Methods. 2010 Aug;51(4):392-8. doi: 10.1016/j.ymeth.2010.05.001. Epub 2010 May 31. Review.

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