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Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.

Weisshuhn PC, Sheppard D, Taylor P, Whiteman P, Lea SM, Handford PA, Redfield C.

Structure. 2016 Apr 5;24(4):555-66. doi: 10.1016/j.str.2016.02.010. Epub 2016 Mar 17.


Glycosylated Notch and Cancer.

Pakkiriswami S, Couto A, Nagarajan U, Georgiou M.

Front Oncol. 2016 Feb 18;6:37. doi: 10.3389/fonc.2016.00037. eCollection 2016. Review.


Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.

Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS.

J Biol Chem. 2016 Mar 25;291(13):6748-53. doi: 10.1074/jbc.C115.701649. Epub 2016 Feb 17.


The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.

De Ford C, Heidersdorf B, Haun F, Murillo R, Friedrich T, Borner C, Merfort I.

Cell Death Dis. 2016 Jan 28;7:e2070. doi: 10.1038/cddis.2015.413.


Notch-Mediated Cell Adhesion.

Murata A, Hayashi S.

Biology (Basel). 2016 Jan 16;5(1). pii: E5. doi: 10.3390/biology5010005. Review.


Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.

Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T.

Autophagy. 2016 Mar 3;12(3):499-514. doi: 10.1080/15548627.2015.1134080. Epub 2016 Jan 4.


The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.

Drusenheimer N, Migdal B, Jäckel S, Tveriakhina L, Scheider K, Schulz K, Gröper J, Köhrer K, Klein T.

PLoS Genet. 2015 Dec 31;11(12):e1005749. doi: 10.1371/journal.pgen.1005749. eCollection 2015 Dec.


Ligand-Independent Mechanisms of Notch Activity.

Palmer WH, Deng WM.

Trends Cell Biol. 2015 Nov;25(11):697-707. doi: 10.1016/j.tcb.2015.07.010. Epub 2015 Oct 1. Review.


TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling.

Ke X, Zhao Y, Lu X, Wang Z, Liu Y, Ren M, Lu G, Zhang D, Sun Z, Xu Z, Song JH, Cheng Y, Meltzer SJ, He S.

Oncotarget. 2015 Oct 20;6(32):32610-21. doi: 10.18632/oncotarget.5362.


Mutational analysis of the Notch2 negative regulatory region identifies key structural elements for mechanical stability.

Stephenson NL, Avis JM.

FEBS Open Bio. 2015 Jul 30;5:625-33. doi: 10.1016/j.fob.2015.07.006. eCollection 2015.


Cryosectioning Method for Microdissection of Murine Colonic Mucosa.

Farkas AE, Gerner-Smidt C, Lili L, Nusrat A, Capaldo CT.

J Vis Exp. 2015 Jul 12;(101):e53112. doi: 10.3791/53112.


SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.

Hass MR, Liow HH, Chen X, Sharma A, Inoue YU, Inoue T, Reeb A, Martens A, Fulbright M, Raju S, Stevens M, Boyle S, Park JS, Weirauch MT, Brent MR, Kopan R.

Mol Cell. 2015 Aug 20;59(4):685-97. doi: 10.1016/j.molcel.2015.07.008. Epub 2015 Aug 6.


Notch Transmembrane Domain: Secondary Structure and Topology.

Deatherage CL, Lu Z, Kim JH, Sanders CR.

Biochemistry. 2015 Jun 16;54(23):3565-8. doi: 10.1021/acs.biochem.5b00456. Epub 2015 Jun 4.


Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M.

J Biol Chem. 2015 Jun 5;290(23):14705-16. doi: 10.1074/jbc.M115.643676. Epub 2015 Apr 27.


O-fucosylation of DLL3 is required for its function during somitogenesis.

Serth K, Schuster-Gossler K, Kremmer E, Hansen B, Marohn-Köhn B, Gossler A.

PLoS One. 2015 Apr 9;10(4):e0123776. doi: 10.1371/journal.pone.0123776. eCollection 2015.


Notch1 phenotype and clinical stage progression in non-small cell lung cancer.

Nguyen D, Rubinstein L, Takebe N, Miele L, Tomaszewski JE, Ivy P, Doroshow JH, Yang SX.

J Hematol Oncol. 2015 Feb 6;8:9. doi: 10.1186/s13045-014-0104-2.


NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth.

Kangsamaksin T, Murtomaki A, Kofler NM, Cuervo H, Chaudhri RA, Tattersall IW, Rosenstiel PE, Shawber CJ, Kitajewski J.

Cancer Discov. 2015 Feb;5(2):182-97. doi: 10.1158/2159-8290.CD-14-0650. Epub 2014 Nov 11.


Spatial and temporal organization of signaling pathways.

Housden BE, Perrimon N.

Trends Biochem Sci. 2014 Oct;39(10):457-64. doi: 10.1016/j.tibs.2014.07.008. Epub 2014 Aug 22. Review.


Activation of the Notch1 Stem Cell Signaling Pathway during Routine Cell Line Subculture.

Liu W, Morgan KM, Pine SR.

Front Oncol. 2014 Aug 6;4:211. doi: 10.3389/fonc.2014.00211. eCollection 2014. Review. No abstract available.


Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation.

Barbaric I, Biga V, Gokhale PJ, Jones M, Stavish D, Glen A, Coca D, Andrews PW.

Stem Cell Reports. 2014 Jun 12;3(1):142-55. doi: 10.1016/j.stemcr.2014.05.006. eCollection 2014 Jul 8.

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