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Items: 20

1.

A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration.

Wan J, Zhu F, Zasadil LM, Yu J, Wang L, Johnson A, Berthier E, Beebe DJ, Audhya A, Weaver BA.

Curr Biol. 2014 Nov 17;24(22):2687-92. doi: 10.1016/j.cub.2014.09.052. Epub 2014 Oct 23.

2.

HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing.

Aksoy P, Abban CY, Kiyashka E, Qiang W, Meneses PI.

Virology. 2014 Jan 20;449:45-52. doi: 10.1016/j.virol.2013.10.034. Epub 2013 Nov 25.

3.

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.

Kato S, Zhang R, Roberts JD Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L130-40. doi: 10.1152/ajplung.00391.2012. Epub 2013 May 17.

4.

Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.

Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, Klein-Szanto AJ.

Neoplasia. 2013 Feb;15(2):169-79.

5.

Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome.

Nicolaou N, Margadant C, Kevelam SH, Lilien MR, Oosterveld MJ, Kreft M, van Eerde AM, Pfundt R, Terhal PA, van der Zwaag B, Nikkels PG, Sachs N, Goldschmeding R, Knoers NV, Renkema KY, Sonnenberg A.

J Clin Invest. 2012 Dec;122(12):4375-87. doi: 10.1172/JCI64100. Epub 2012 Nov 1.

6.

Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.

Fu J, Bassi DE, Zhang J, Li T, Nicolas E, Klein-Szanto AJ.

Neoplasia. 2012 Apr;14(4):271-82.

7.

Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.

Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, Elias CF, Lowell BB, Elmquist JK.

J Comp Neurol. 2012 Nov 1;520(16):3617-32. doi: 10.1002/cne.23116.

8.

Embryo implantation is closely associated with dynamic expression of proprotein convertase 5/6 in the rabbit uterus.

Nicholls PK, Sun Z, Heng S, Li Y, Wang J, Nie G.

Reprod Biol Endocrinol. 2011 Apr 6;9:43. doi: 10.1186/1477-7827-9-43.

9.

Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.

Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ.

Neoplasia. 2010 Jul;12(7):516-26.

10.

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.

Sun X, Essalmani R, Seidah NG, Prat A.

Mol Cancer. 2009 Sep 8;8:73. doi: 10.1186/1476-4598-8-73.

11.

A role for pericytes as microenvironmental regulators of human skin tissue regeneration.

Paquet-Fifield S, Schlüter H, Li A, Aitken T, Gangatirkar P, Blashki D, Koelmeyer R, Pouliot N, Palatsides M, Ellis S, Brouard N, Zannettino A, Saunders N, Thompson N, Li J, Kaur P.

J Clin Invest. 2009 Sep;119(9):2795-806. doi: 10.1172/JCI38535. Epub 2009 Aug 3.

12.

Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.

Fuller JA, Brun-Zinkernagel AM, Clark AF, Wordinger RJ.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5759-68. doi: 10.1167/iovs.08-2616. Epub 2009 Apr 1.

13.

Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.

Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, Day R, Smith JW, Lebl M, Strongin AY.

J Biol Chem. 2008 Jul 25;283(30):20897-906. doi: 10.1074/jbc.M803762200. Epub 2008 May 27.

14.

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A.

Mol Cell Biol. 2006 Jan;26(1):354-61.

15.

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG.

Mol Biol Cell. 2005 Nov;16(11):5215-26. Epub 2005 Aug 31.

16.

Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model.

Nejjari M, Berthet V, Rigot V, Laforest S, Jacquier MF, Seidah NG, Remy L, Bruyneel E, Scoazec JY, Marvaldi J, Luis J.

Am J Pathol. 2004 Jun;164(6):1925-33.

17.

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM.

J Clin Invest. 2003 Jun;111(11):1723-32.

18.

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.

Bergeron E, Basak A, Decroly E, Seidah NG.

Biochem J. 2003 Jul 15;373(Pt 2):475-84.

19.

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.

Khatib AM, Siegfried G, Chrétien M, Metrakos P, Seidah NG.

Am J Pathol. 2002 Jun;160(6):1921-35. Review.

20.

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme.

Dubois CM, Blanchette F, Laprise MH, Leduc R, Grondin F, Seidah NG.

Am J Pathol. 2001 Jan;158(1):305-16.

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