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Items: 1 to 20 of 54

1.

EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.

Luo Y, Blechingberg J, Fernandes AM, Li S, Fryland T, Børglum AD, Bolund L, Nielsen AL.

BMC Genomics. 2015 Nov 14;16(1):929. doi: 10.1186/s12864-015-2125-9.

2.

Emerging mechanisms of molecular pathology in ALS.

Peters OM, Ghasemi M, Brown RH Jr.

J Clin Invest. 2015 May;125(5):1767-79. doi: 10.1172/JCI71601. Epub 2015 May 1. Review. Erratum in: J Clin Invest. 2015 Jun;125(6):2548.

3.
4.

FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.

Kino Y, Washizu C, Kurosawa M, Yamada M, Miyazaki H, Akagi T, Hashikawa T, Doi H, Takumi T, Hicks GG, Hattori N, Shimogori T, Nukina N.

Acta Neuropathol Commun. 2015 Apr 25;3:24. doi: 10.1186/s40478-015-0202-6.

5.

A loss of FUS/TLS function leads to impaired cellular proliferation.

Ward CL, Boggio KJ, Johnson BN, Boyd JB, Douthwright S, Shaffer SA, Landers JE, Glicksman MA, Bosco DA.

Cell Death Dis. 2014 Dec 11;5:e1572. doi: 10.1038/cddis.2014.508.

6.

Functions of FUS/TLS from DNA repair to stress response: implications for ALS.

Sama RR, Ward CL, Bosco DA.

ASN Neuro. 2014 Jun 1;6(4). pii: 1759091414544472. doi: 10.1177/1759091414544472. Review.

7.

FUS-regulated RNA metabolism and DNA damage repair: Implications for amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis.

Zhou Y, Liu S, Oztürk A, Hicks GG.

Rare Dis. 2014 Jun 12;2:e29515. doi: 10.4161/rdis.29515. eCollection 2014.

8.

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR.

Mol Biol Cell. 2014 Sep 1;25(17):2571-8. doi: 10.1091/mbc.E14-05-1007. Epub 2014 Jul 9.

9.

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

Deng Q, Holler CJ, Taylor G, Hudson KF, Watkins W, Gearing M, Ito D, Murray ME, Dickson DW, Seyfried NT, Kukar T.

J Neurosci. 2014 Jun 4;34(23):7802-13. doi: 10.1523/JNEUROSCI.0172-14.2014.

10.

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.

Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ.

J Clin Invest. 2014 Mar;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10.

11.

Ewing sarcoma protein: a key player in human cancer.

Paronetto MP.

Int J Cell Biol. 2013;2013:642853. doi: 10.1155/2013/642853. Epub 2013 Sep 3. Review.

12.

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW.

Nucleic Acids Res. 2014 Jan;42(1):307-14. doi: 10.1093/nar/gkt835. Epub 2013 Sep 18.

13.

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.

Ling SC, Polymenidou M, Cleveland DW.

Neuron. 2013 Aug 7;79(3):416-38. doi: 10.1016/j.neuron.2013.07.033. Review.

14.

FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.

Dhar SK, Zhang J, Gal J, Xu Y, Miao L, Lynn BC, Zhu H, Kasarskis EJ, St Clair DK.

Antioxid Redox Signal. 2014 Apr 1;20(10):1550-66. doi: 10.1089/ars.2012.4984. Epub 2013 Sep 20.

15.

The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage.

Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS.

J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5.

16.

Non-coding RNAs in DNA damage and repair.

Sharma V, Misteli T.

FEBS Lett. 2013 Jun 27;587(13):1832-9. doi: 10.1016/j.febslet.2013.05.006. Epub 2013 May 16. Review.

17.

Protein aggregation in amyotrophic lateral sclerosis.

Blokhuis AM, Groen EJ, Koppers M, van den Berg LH, Pasterkamp RJ.

Acta Neuropathol. 2013 Jun;125(6):777-94. doi: 10.1007/s00401-013-1125-6. Epub 2013 May 15. Review.

18.

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress.

Sama RR, Ward CL, Kaushansky LJ, Lemay N, Ishigaki S, Urano F, Bosco DA.

J Cell Physiol. 2013 Nov;228(11):2222-31. doi: 10.1002/jcp.24395.

19.

Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.

Scaramuzzino C, Monaghan J, Milioto C, Lanson NA Jr, Maltare A, Aggarwal T, Casci I, Fackelmayer FO, Pennuto M, Pandey UB.

PLoS One. 2013 Apr 19;8(4):e61576. doi: 10.1371/journal.pone.0061576. Print 2013.

20.

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.

Mitchell JC, McGoldrick P, Vance C, Hortobagyi T, Sreedharan J, Rogelj B, Tudor EL, Smith BN, Klasen C, Miller CC, Cooper JD, Greensmith L, Shaw CE.

Acta Neuropathol. 2013 Feb;125(2):273-88. doi: 10.1007/s00401-012-1043-z. Epub 2012 Sep 9.

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