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USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.

Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D.

Nature. 2016 Apr 21;532(7599):398-401. doi: 10.1038/nature17433. Epub 2016 Apr 13.


Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs).

Gao Y, Li Y, Zhang C, Zhao M, Deng C, Lan Q, Liu Z, Su N, Wang J, Xu F, Xu Y, Ping L, Chang L, Gao H, Wu J, Xue Y, Deng Z, Peng J, Xu P.

Mol Cell Proteomics. 2016 Apr;15(4):1381-96. doi: 10.1074/mcp.M115.051839.


The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates.

Pinto MJ, Alves PL, Martins L, Pedro JR, Ryu HR, Jeon NL, Taylor AM, Almeida RD.

J Cell Biol. 2016 Mar 28;212(7):789-801. doi: 10.1083/jcb.201509039.


Ubiquitin modifications.

Swatek KN, Komander D.

Cell Res. 2016 Apr;26(4):399-422. doi: 10.1038/cr.2016.39. Epub 2016 Mar 25. Review.


Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells.

Iskandarani A, Bhat AA, Siveen KS, Prabhu KS, Kuttikrishnan S, Khan MA, Krishnankutty R, Kulinski M, Nasr RR, Mohammad RM, Uddin S.

J Transl Med. 2016 Mar 9;14(1):69. doi: 10.1186/s12967-016-0823-y.


Structure of an endogenous yeast 26S proteasome reveals two major conformational states.

Luan B, Huang X, Wu J, Mei Z, Wang Y, Xue X, Yan C, Wang J, Finley DJ, Shi Y, Wang F.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2642-7. doi: 10.1073/pnas.1601561113. Epub 2016 Feb 29.


It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.

Tramutola A, Di Domenico F, Barone E, Perluigi M, Butterfield DA.

Oxid Med Cell Longev. 2016;2016:2756068. doi: 10.1155/2016/2756068. Epub 2016 Jan 5. Review.


Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains.

Rahighi S, Braunstein I, Ternette N, Kessler B, Kawasaki M, Kato R, Matsui T, Weiss TM, Stanhill A, Wakatsuki S.

Structure. 2016 Mar 1;24(3):412-22. doi: 10.1016/j.str.2015.12.017. Epub 2016 Feb 11.


UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.

Du C, Wu H, Leng RP.

Oncotarget. 2016 Jan 19;7(3):2823-36. doi: 10.18632/oncotarget.6555.


Gates, Channels, and Switches: Elements of the Proteasome Machine.

Finley D, Chen X, Walters KJ.

Trends Biochem Sci. 2016 Jan;41(1):77-93. doi: 10.1016/j.tibs.2015.10.009. Epub 2015 Nov 28. Review.


SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.

Canzonetta C, Vernarecci S, Iuliani M, Marracino C, Belloni C, Ballario P, Filetici P.

G3 (Bethesda). 2015 Nov 27;6(2):287-98. doi: 10.1534/g3.115.024877.


The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33.

Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G, Li B.

Int J Mol Sci. 2015 Nov 24;16(11):27956-66. doi: 10.3390/ijms161126063.


Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.

Pham GH, Rana AS, Korkmaz EN, Trang VH, Cui Q, Strieter ER.

Protein Sci. 2016 Feb;25(2):456-71. doi: 10.1002/pro.2834. Epub 2016 Jan 12.


Lysine11-Linked Polyubiquitination of the AnkB F-Box Effector of Legionella pneumophila.

Bruckert WM, Abu Kwaik Y.

Infect Immun. 2015 Oct 19;84(1):99-107. doi: 10.1128/IAI.01165-15.


HIF-1╬▒ Upregulation due to Depletion of the Free Ubiquitin Pool.

Kim J, So D, Shin HW, Chun YS, Park JW.

J Korean Med Sci. 2015 Oct;30(10):1388-95. doi: 10.3346/jkms.2015.30.10.1388. Epub 2015 Sep 12.


Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease.

Gentier RJ, van Leeuwen FW.

Front Mol Neurosci. 2015 Sep 2;8:47. doi: 10.3389/fnmol.2015.00047. eCollection 2015. Review.


Intracellular Dynamics of the Ubiquitin-Proteasome-System.

Chowdhury M, Enenkel C.

F1000Res. 2015 Jul 24;4:367. doi: 10.12688/f1000research.6835.1. eCollection 2015. Review.


Cullin4 Is Pro-Viral during West Nile Virus Infection of Culex Mosquitoes.

Paradkar PN, Duchemin JB, Rodriguez-Andres J, Trinidad L, Walker PJ.

PLoS Pathog. 2015 Sep 1;11(9):e1005143. doi: 10.1371/journal.ppat.1005143. eCollection 2015 Sep.


An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.

Girard JR, Tenthorey JL, Morgan DO.

J Biol Chem. 2015 Oct 2;290(40):24614-25. doi: 10.1074/jbc.M115.678193. Epub 2015 Aug 25.


MuRF2 regulates PPAR╬│1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.

He J, Quintana MT, Sullivan J, L Parry T, J Grevengoed T, Schisler JC, Hill JA, Yates CC, Mapanga RF, Essop MF, Stansfield WE, Bain JR, Newgard CB, Muehlbauer MJ, Han Y, Clarke BA, Willis MS.

Cardiovasc Diabetol. 2015 Aug 5;14:97. doi: 10.1186/s12933-015-0252-x.

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