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Items: 1 to 20 of 28


PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.

Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R.

Sci Rep. 2016 Jan 8;6:18979. doi: 10.1038/srep18979.


Generation of a single chain antibody variable fragment (scFv) to sense selectively RhoB activation.

Chinestra P, Olichon A, Medale-Giamarchi C, Lajoie-Mazenc I, Gence R, Inard C, Ligat L, Faye JC, Favre G.

PLoS One. 2014 Nov 3;9(11):e111034. doi: 10.1371/journal.pone.0111034. eCollection 2014.


Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.

Chamberlain P, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbasian M, Muir J, Raheja N, Cathers B.

PLoS One. 2014 Aug 11;9(8):e103638. doi: 10.1371/journal.pone.0103638. eCollection 2014.


Protein Kinase C-Related Kinase (PKN/PRK). Potential Key-Role for PKN1 in Protection of Hypoxic Neurons.

Thauerer B, Zur Nedden S, Baier-Bitterlich G.

Curr Neuropharmacol. 2014 May;12(3):213-8. doi: 10.2174/1570159X11666131225000518.


Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology.

Mohan S, Das D, Bauer RJ, Heroux A, Zalewski JK, Heber S, Dosunmu-Ogunbi AM, Trakselis MA, Hildebrand JD, Vandemark AP.

PLoS One. 2013 Dec 9;8(12):e81075. doi: 10.1371/journal.pone.0081075. eCollection 2013.


Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.

Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F.

Mol Cell Biol. 2014 Feb;34(3):362-73. doi: 10.1128/MCB.01360-13. Epub 2013 Nov 18.


A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions.

LaRock DL, Brzovic PS, Levin I, Blanc MP, Miller SI.

J Biol Chem. 2012 Aug 24;287(35):29654-63. doi: 10.1074/jbc.M112.363598. Epub 2012 Jun 27.


The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.

Kato K, Yazawa T, Taki K, Mori K, Wang S, Nishioka T, Hamaguchi T, Itoh T, Takenawa T, Kataoka C, Matsuura Y, Amano M, Murohara T, Kaibuchi K.

Mol Biol Cell. 2012 Jul;23(13):2593-604. doi: 10.1091/mbc.E11-11-0958. Epub 2012 May 16.


Regulation of protein kinase C-related protein kinase 2 (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain.

Bauer AF, Sonzogni S, Meyer L, Zeuzem S, Piiper A, Biondi RM, Neimanis S.

J Biol Chem. 2012 Jun 8;287(24):20590-602. doi: 10.1074/jbc.M111.327437. Epub 2012 Apr 16.


Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors.

McGrail DJ, Ghosh D, Quach ND, Dawson MR.

PLoS One. 2012;7(3):e33248. doi: 10.1371/journal.pone.0033248. Epub 2012 Mar 16.


Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.

Lachmann S, Jevons A, De Rycker M, Casamassima A, Radtke S, Collazos A, Parker PJ.

PLoS One. 2011;6(7):e21732. doi: 10.1371/journal.pone.0021732. Epub 2011 Jul 6.


The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.

Fenwick RB, Campbell LJ, Rajasekar K, Prasannan S, Nietlispach D, Camonis J, Owen D, Mott HR.

Structure. 2010 Aug 11;18(8):985-95. doi: 10.1016/j.str.2010.05.013.


Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC.

J Biol Chem. 2010 Jul 2;285(27):21070-81. doi: 10.1074/jbc.M110.122549. Epub 2010 Apr 29.


Specificity of interactions between mDia isoforms and Rho proteins.

Lammers M, Meyer S, K├╝hlmann D, Wittinghofer A.

J Biol Chem. 2008 Dec 12;283(50):35236-46. doi: 10.1074/jbc.M805634200. Epub 2008 Sep 30.


Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.

Gavard J, Gutkind JS.

J Biol Chem. 2008 Oct 31;283(44):29888-96. doi: 10.1074/jbc.M803880200. Epub 2008 Aug 19.


Fragmentation of protein kinase N (PKN) in the hydrocephalic rat brain.

Okii N, Amano T, Seki T, Matsubayashi H, Mukai H, Ono Y, Kurisu K, Sakai N.

Acta Histochem Cytochem. 2007 Aug 30;40(4):113-21.


Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans.

McMullan R, Hiley E, Morrison P, Nurrish SJ.

Genes Dev. 2006 Jan 1;20(1):65-76.

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