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Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications.

Alunno A, Manetti M, Caterbi S, Ibba-Manneschi L, Bistoni O, Bartoloni E, Valentini V, Terenzi R, Gerli R.

Mediators Inflamm. 2015;2015:751793. Epub 2015 Mar 30. Review.


Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis.

Andersson A, Stubelius A, Karlsson MN, Engdahl C, Erlandsson M, Grahnemo L, Lagerquist MK, Islander U.

Arthritis Res Ther. 2015 Feb 13;17(1):32. doi: 10.1186/s13075-015-0548-y.


Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1.

Heckt T, Bickert T, Jeschke A, Seitz S, Schulze J, Ito WD, Zimmermann W, Amling M, Schinke T, Horst AK, Keller J.

PLoS One. 2014 Dec 9;9(12):e114360. doi: 10.1371/journal.pone.0114360. eCollection 2014.


T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.

Raphael I, Nalawade S, Eagar TN, Forsthuber TG.

Cytokine. 2014 Oct 30. pii: S1043-4666(14)00539-0. doi: 10.1016/j.cyto.2014.09.011. [Epub ahead of print] Review.


Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis.

Dixit N, Wu DJ, Belgacem YH, Borodinsky LN, Gershwin ME, Adamopoulos IE.

Arthritis Res Ther. 2014 Dec 2;16(6):496. doi: 10.1186/s13075-014-0496-y.


Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density.

Grahnemo L, Jochems C, Andersson A, Engdahl C, Ohlsson C, Islander U, Carlsten H.

J Endocrinol. 2015 Jan;224(1):97-108. doi: 10.1530/JOE-14-0508. Epub 2014 Oct 30.


Cytokine-mediated bone destruction in rheumatoid arthritis.

Jung SM, Kim KW, Yang CW, Park SH, Ju JH.

J Immunol Res. 2014;2014:263625. doi: 10.1155/2014/263625. Epub 2014 Sep 10.


Tissue specific CD4+ T cell priming determines the requirement for interleukin-23 in experimental arthritis.

Olalekan SA, Cao Y, Finnegan A.

Arthritis Res Ther. 2014 Sep 25;16(5):440. doi: 10.1186/s13075-014-0440-1.


Effects of Interleukin-17A on Osteogenic Differentiation of Isolated Human Mesenchymal Stem Cells.

Osta B, Lavocat F, Eljaafari A, Miossec P.

Front Immunol. 2014 Sep 2;5:425. doi: 10.3389/fimmu.2014.00425. eCollection 2014.


Anti-inflammatory effects of recombinant human PDCD5 (rhPDCD5) in a rat collagen-induced model of arthritis.

Xiao J, Li G, Hu J, Qu L, Ma D, Chen Y.

Inflammation. 2015 Feb;38(1):70-8. doi: 10.1007/s10753-014-0008-x.


Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

van Baarsen LG, Lebre MC, van der Coelen D, Aarrass S, Tang MW, Ramwadhdoebe TH, Gerlag DM, Tak PP.

Arthritis Res Ther. 2014 Aug 22;16(4):426. doi: 10.1186/s13075-014-0426-z.


Role of Th17 Cells in the Pathogenesis of Human IBD.

Gálvez J.

ISRN Inflamm. 2014 Mar 25;2014:928461. doi: 10.1155/2014/928461. eCollection 2014. Review.


The role of IL-17 promotes spinal cord neuroinflammation via activation of the transcription factor STAT3 after spinal cord injury in the rat.

Zong S, Zeng G, Fang Y, Peng J, Tao Y, Li K, Zhao J.

Mediators Inflamm. 2014;2014:786947. doi: 10.1155/2014/786947. Epub 2014 Apr 30.


Interleukin 17A promotes gastric cancer invasiveness via NF-κB mediated matrix metalloproteinases 2 and 9 expression.

Wang Y, Wu H, Wu X, Bian Z, Gao Q.

PLoS One. 2014 Jun 6;9(6):e96678. doi: 10.1371/journal.pone.0096678. eCollection 2014.


TLR2 elicits IL-17-mediated RANKL expression, IL-17, and OPG production in neutrophils from arthritic mice.

Milanova V, Ivanovska N, Dimitrova P.

Mediators Inflamm. 2014;2014:643406. doi: 10.1155/2014/643406. Epub 2014 Mar 16.


Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.

Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R.

J Biol Chem. 2014 May 30;289(22):15621-30. doi: 10.1074/jbc.M113.520510. Epub 2014 Apr 22.


Interleukin-17 impedes Schwann cell-mediated myelination.

Stettner M, Lohmann B, Wolffram K, Weinberger JP, Dehmel T, Hartung HP, Mausberg AK, Kieseier BC.

J Neuroinflammation. 2014 Mar 29;11:63. doi: 10.1186/1742-2094-11-63.


Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches.

Roy LD, Sahraei M, Schettini JL, Gruber HE, Besmer DM, Mukherjee P.

BMC Cancer. 2014 Mar 27;14:225. doi: 10.1186/1471-2407-14-225.


NF-κB Activation in T Helper 17 Cell Differentiation.

Park SH, Cho G, Park SG.

Immune Netw. 2014 Feb;14(1):14-20. doi: 10.4110/in.2014.14.1.14. Epub 2014 Feb 21.

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