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Results: 1 to 20 of 706

1.

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

Ding J, Das K, Hsiou Y, Sarafianos SG, Clark AD Jr, Jacobo-Molina A, Tantillo C, Hughes SH, Arnold E.

J Mol Biol. 1998 Dec 11;284(4):1095-111.

PMID:
9837729
[PubMed - indexed for MEDLINE]
2.
3.

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase.

Patel PH, Jacobo-Molina A, Ding J, Tantillo C, Clark AD Jr, Raag R, Nanni RG, Hughes SH, Arnold E.

Biochemistry. 1995 Apr 25;34(16):5351-63.

PMID:
7537090
[PubMed - indexed for MEDLINE]
4.

Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain.

Najmudin S, Coté ML, Sun D, Yohannan S, Montano SP, Gu J, Georgiadis MM.

J Mol Biol. 2000 Feb 18;296(2):613-32.

PMID:
10669612
[PubMed - indexed for MEDLINE]
5.

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E.

J Mol Biol. 1996 Dec 20;264(5):1085-100.

PMID:
9000632
[PubMed - indexed for MEDLINE]
6.

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

Jacobo-Molina A, Ding J, Nanni RG, Clark AD Jr, Lu X, Tantillo C, Williams RL, Kamer G, Ferris AL, Clark P, et al.

Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4.

PMID:
7687065
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.

Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, Pauwels R, Andries K, Janssen PA, Arnold E.

J Mol Biol. 1994 Oct 28;243(3):369-87. Review.

PMID:
7525966
[PubMed - indexed for MEDLINE]
8.

Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.

Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E.

Structure. 1996 Jul 15;4(7):853-60.

PMID:
8805568
[PubMed - indexed for MEDLINE]
9.
10.

Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis.

Kaushik N, Harris D, Rege N, Modak MJ, Yadav PN, Pandey VN.

Biochemistry. 1997 Nov 25;36(47):14430-8.

PMID:
9398161
[PubMed - indexed for MEDLINE]
11.

Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer.

Upadhyay AK, Talele TT, Pandey VN.

Mol Cell Biochem. 2010 May;338(1-2):19-33. doi: 10.1007/s11010-009-0316-x. Epub 2009 Nov 17.

PMID:
19921401
[PubMed - indexed for MEDLINE]
12.

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution.

Ding J, Das K, Tantillo C, Zhang W, Clark AD Jr, Jessen S, Lu X, Hsiou Y, Jacobo-Molina A, Andries K, et al.

Structure. 1995 Apr 15;3(4):365-79.

PMID:
7542140
[PubMed - indexed for MEDLINE]
13.

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E.

J Mol Biol. 2007 Jan 5;365(1):77-89. Epub 2006 Sep 15.

PMID:
17056061
[PubMed - indexed for MEDLINE]
14.

Structure of HIV-1 reverse transcriptase/DNA complex at 7 A resolution showing active site locations.

Arnold E, Jacobo-Molina A, Nanni RG, Williams RL, Lu X, Ding J, Clark AD Jr, Zhang A, Ferris AL, Clark P, et al.

Nature. 1992 May 7;357(6373):85-9.

PMID:
1374166
[PubMed - indexed for MEDLINE]
15.

2.2 A resolution structure of the amino-terminal half of HIV-1 reverse transcriptase (fingers and palm subdomains).

Unge T, Knight S, Bhikhabhai R, Lövgren S, Dauter Z, Wilson K, Strandberg B.

Structure. 1994 Oct 15;2(10):953-61.

PMID:
7532533
[PubMed - indexed for MEDLINE]
16.

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

Arora K, Beard WA, Wilson SH, Schlick T.

Biochemistry. 2005 Oct 11;44(40):13328-41.

PMID:
16201758
[PubMed - indexed for MEDLINE]
17.

Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions.

Beard WA, Bebenek K, Darden TA, Li L, Prasad R, Kunkel TA, Wilson SH.

J Biol Chem. 1998 Nov 13;273(46):30435-42.

PMID:
9804810
[PubMed - indexed for MEDLINE]
Free Article
18.

Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer.

Peletskaya EN, Boyer PL, Kogon AA, Clark P, Kroth H, Sayer JM, Jerina DM, Hughes SH.

J Virol. 2001 Oct;75(19):9435-45.

PMID:
11533206
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

p66 Trp24 and Phe61 are essential for accurate association of HIV-1 reverse transcriptase with primer/template.

Agopian A, Depollier J, Lionne C, Divita G.

J Mol Biol. 2007 Oct 12;373(1):127-40. Epub 2007 Aug 2.

PMID:
17804012
[PubMed - indexed for MEDLINE]
20.

Extending the understanding of mutagenicity: structural insights into primer-extension past a benzo[a]pyrene diol epoxide-DNA adduct.

Perlow RA, Broyde S.

J Mol Biol. 2003 Apr 4;327(4):797-818.

PMID:
12654264
[PubMed - indexed for MEDLINE]

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