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Items: 1 to 20 of 154

1.

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

Berryman KA, Edmunds JJ, Bunker AM, Haleen S, Bryant J, Welch KM, Doherty AM.

Bioorg Med Chem. 1998 Sep;6(9):1447-56.

PMID:
9801816
2.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).

Liu G, Henry KJ Jr, Szczepankiewicz BG, Winn M, Kozmina NS, Boyd SA, Wasicak J, von Geldern TW, Wu-Wong JR, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ.

J Med Chem. 1998 Aug 13;41(17):3261-75.

PMID:
9703472
3.

Discovery and development of an endothelin A receptor-selective antagonist PD 156707.

Doherty AM, Uprichard AC.

Pharm Biotechnol. 1998;11:81-112. Review.

PMID:
9760677
4.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.

Jae HS, Winn M, von Geldern TW, Sorensen BK, Chiou WJ, Nguyen B, Marsh KC, Opgenorth TJ.

J Med Chem. 2001 Nov 8;44(23):3978-84.

PMID:
11689084
5.

Synthesis and structure-activity relationships in a series of ethenesulfonamide derivatives, a novel class of endothelin receptor antagonists.

Harada H, Kazami J, Watanuki S, Tsuzuki R, Sudoh K, Fujimori A, Tokunaga T, Tanaka A, Tsukamoto S, Yanagisawa I.

Chem Pharm Bull (Tokyo). 2001 Dec;49(12):1593-603.

7.

Pharmacological characterization of PD 156707, an orally active ETA receptor antagonist.

Reynolds EE, Keiser JA, Haleen SJ, Walker DM, Olszewski B, Schroeder RL, Taylor DG, Hwang O, Welch KM, Flynn MA, et al.

J Pharmacol Exp Ther. 1995 Jun;273(3):1410-7.

PMID:
7791115
8.

Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.

Tasker AS, Sorensen BK, Jae HS, Winn M, von Geldern TW, Dixon DB, Chiou WJ, Dayton BD, Calzadila S, Hernandez L, Marsh KC, WuWong JR, Opgenorth TJ.

J Med Chem. 1997 Jan 31;40(3):322-30.

PMID:
9022798
9.

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T.

J Med Chem. 2006 Mar 23;49(6):2022-7.

PMID:
16539390
10.

Butenolide endothelin antagonists with improved aqueous solubility.

Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA.

J Med Chem. 1999 Jun 17;42(12):2162-8.

PMID:
10377221
11.

The discovery and structure-activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ET(B) receptor.

Chan MF, Kois A, Verner EJ, Raju BG, Castillo RS, Wu C, Okun I, Stavros FD, Balaji VN.

Bioorg Med Chem. 1998 Dec;6(12):2301-16.

PMID:
9925292
12.
13.

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM.

J Med Chem. 1997 Mar 28;40(7):1063-74.

PMID:
9089328
14.

Synthesis, antimalarial activity, structure-activity relationship analysis of thieno-[3,2-b]benzothiazine S,S-dioxide analogs.

Barazarte A, Camacho J, Domínguez J, Lobo G, Gamboa N, Rodrigues J, Capparelli MV, Alvarez-Larena A, Andujar S, Enriz D, Charris J.

Bioorg Med Chem. 2008 Apr 1;16(7):3661-74. doi: 10.1016/j.bmc.2008.02.011. Epub 2008 Feb 8.

PMID:
18314337
15.

Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors.

Bakavoli M, Nikpour M, Rahimizadeh M, Saberi MR, Sadeghian H.

Bioorg Med Chem. 2007 Mar 1;15(5):2120-6. Epub 2006 Dec 14.

PMID:
17210254
16.

Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.

Murugesan N, Gu Z, Stein PD, Spergel S, Bisaha S, Liu EC, Zhang R, Webb ML, Moreland S, Barrish JC.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):517-20.

PMID:
11844662
17.

Solid-phase synthesis of endothelin receptor antagonists.

Lange UE, Braje WM, Amberg W, Kettschau G.

Bioorg Med Chem Lett. 2003 May 19;13(10):1721-4.

PMID:
12729650
18.

Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives.

Barazarte A, Lobo G, Gamboa N, Rodrigues JR, Capparelli MV, Alvarez-Larena A, López SE, Charris JE.

Eur J Med Chem. 2009 Mar;44(3):1303-10. doi: 10.1016/j.ejmech.2008.08.005. Epub 2008 Aug 26.

PMID:
18835067
19.

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al.

J Med Chem. 1995 Apr 14;38(8):1259-63. No abstract available.

PMID:
7731010
20.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.

de Vicente J, Hendricks RT, Smith DB, Fell JB, Fischer J, Spencer SR, Stengel PJ, Mohr P, Robinson JE, Blake JF, Hilgenkamp RK, Yee C, Adjabeng G, Elworthy TR, Tracy J, Chin E, Li J, Wang B, Bamberg JT, Stephenson R, Oshiro C, Harris SF, Ghate M, Leveque V, Najera I, Le Pogam S, Rajyaguru S, Ao-Ieong G, Alexandrova L, Larrabee S, Brandl M, Briggs A, Sukhtankar S, Farrell R, Xu B.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3642-6. doi: 10.1016/j.bmcl.2009.05.004. Epub 2009 May 7.

PMID:
19457662
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