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Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

Wadhwa R, Takano S, Robert M, Yoshida A, Nomura H, Reddel RR, Mitsui Y, Kaul SC.

J Biol Chem. 1998 Nov 6;273(45):29586-91.


Transcriptional inactivation of p53 by deletions and single amino acid changes in mouse mot-1 protein.

Kaul SC, Takano S, Reddel RR, Mitsui Y, Wadhwa R.

Biochem Biophys Res Commun. 2000 Dec 20;279(2):602-6.


Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.

Wadhwa R, Yaguchi T, Hasan MK, Mitsui Y, Reddel RR, Kaul SC.

Exp Cell Res. 2002 Apr 1;274(2):246-53.


Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein.

Kaul SC, Duncan EL, Englezou A, Takano S, Reddel RR, Mitsui Y, Wadhwa R.

Oncogene. 1998 Aug 20;17(7):907-11.


Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.

Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, Maruta H, Kaul SC.

Cancer Res. 2000 Dec 15;60(24):6818-21.


Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.

Kaul SC, Aida S, Yaguchi T, Kaur K, Wadhwa R.

J Biol Chem. 2005 Nov 25;280(47):39373-9. Epub 2005 Sep 21.


Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2.

Kaula SC, Reddelb RR, Sugiharac T, Mitsuia Y, Wadhwac R.

FEBS Lett. 2000 Jun 2;474(2-3):159-64.


Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells.

Wadhwa R, Kaul SC, Sugimoto Y, Mitsui Y.

J Biol Chem. 1993 Oct 25;268(30):22239-42.


Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids.

Deocaris CC, Yamasaki K, Kaul SC, Wadhwa R.

Ann N Y Acad Sci. 2006 May;1067:220-3.


Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.

Sane S, Abdullah A, Boudreau DA, Autenried RK, Gupta BK, Wang X, Wang H, Schlenker EH, Zhang D, Telleria C, Huang L, Chauhan SC, Rezvani K.

Cell Death Dis. 2014 Mar 13;5:e1118. doi: 10.1038/cddis.2014.100.


Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

Murphy PJ, Galigniana MD, Morishima Y, Harrell JM, Kwok RP, Ljungman M, Pratt WB.

J Biol Chem. 2004 Jul 16;279(29):30195-201. Epub 2004 May 15.


Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification.

Knights CD, Liu Y, Appella E, Kulesz-Martin M.

J Biol Chem. 2003 Dec 26;278(52):52890-900. Epub 2003 Oct 10.


The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.

Li Y, Ling M, Xu Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Toxicol Sci. 2010 Jul;116(1):174-82. doi: 10.1093/toxsci/kfq109. Epub 2010 Apr 7.


mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells.

Li Y, Xu Y, Ling M, Yang Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Environ Health Perspect. 2010 Jul;118(7):936-42. doi: 10.1289/ehp.0901677. Epub 2010 Mar 3.


Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription.

Muralidhar S, Doniger J, Mendelson E, Araujo JC, Kashanchi F, Azumi N, Brady JN, Rosenthal LJ.

J Virol. 1996 Dec;70(12):8691-700.


Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.

Frese S, Schaper M, Kuster JR, Miescher D, Jäättelä M, Buehler T, Schmid RA.

J Thorac Cardiovasc Surg. 2003 Sep;126(3):748-54.


Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.

Sugihara T, Kaul SC, Kato J, Reddel RR, Nomura H, Wadhwa R.

J Biol Chem. 2001 Jun 1;276(22):18649-52. Epub 2001 Mar 19.

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