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Items: 1 to 20 of 465

1.

Senescence of human fibroblasts induced by oncogenic Raf.

Zhu J, Woods D, McMahon M, Bishop JM.

Genes Dev. 1998 Oct 1;12(19):2997-3007.

2.

Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation.

Fanton CP, McMahon M, Pieper RO.

J Biol Chem. 2001 Jun 1;276(22):18871-7. Epub 2001 Mar 15.

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M.

Mol Cell Biol. 1997 Sep;17(9):5598-611.

6.

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.

Zou X, Ray D, Aziyu A, Christov K, Boiko AD, Gudkov AV, Kiyokawa H.

Genes Dev. 2002 Nov 15;16(22):2923-34.

7.

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW.

Genes Dev. 1998 Oct 1;12(19):3008-19.

8.

Long-term growth arrest of PUVA-treated fibroblasts in G2/M in the absence of p16(INK4a) p21(CIP1) or p53.

Ma W, Hommel C, Brenneisen P, Peters T, Smit N, Sedivy J, Scharffetter-Kochanek K, Wlaschek M.

Exp Dermatol. 2003 Oct;12(5):629-37.

PMID:
14705804
9.

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).

Malumbres M, Pérez De Castro I, Hernández MI, Jiménez M, Corral T, Pellicer A.

Mol Cell Biol. 2000 Apr;20(8):2915-25.

10.

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

Shin J, Yang J, Lee JC, Baek KH.

Cell Signal. 2013 Dec;25(12):2540-7. doi: 10.1016/j.cellsig.2013.08.014. Epub 2013 Aug 30.

PMID:
23993963
11.

E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).

Westbrook TF, Nguyen DX, Thrash BR, McCance DJ.

Mol Cell Biol. 2002 Oct;22(20):7041-52.

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RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt.

Thaler S, Hähnel PS, Schad A, Dammann R, Schuler M.

Cancer Res. 2009 Mar 1;69(5):1748-57. doi: 10.1158/0008-5472.CAN-08-1377. Epub 2009 Feb 17.

14.

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT.

Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M.

Mol Cell Biol. 2004 Dec;24(24):10868-81.

15.

Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells.

Ravi RK, Thiagalingam A, Weber E, McMahon M, Nelkin BD, Mabry M.

Am J Respir Cell Mol Biol. 1999 Apr;20(4):543-9.

PMID:
10100985
16.

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts.

Dulić V, Beney GE, Frebourg G, Drullinger LF, Stein GH.

Mol Cell Biol. 2000 Sep;20(18):6741-54.

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Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1.

Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, Rivas C, Burgering BM, Serrano M, Lam EW.

J Biol Chem. 2000 Jul 21;275(29):21960-8.

20.

Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression.

Kim DI, Lee SJ, Lee SB, Park K, Kim WJ, Moon SK.

Carcinogenesis. 2008 Sep;29(9):1701-9. doi: 10.1093/carcin/bgn055. Epub 2008 Feb 22.

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