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Results: 1 to 20 of 108

1.

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.

Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR.

Proteins. 1998 Aug 15;32(3):350-61.

PMID:
9715911
[PubMed - indexed for MEDLINE]
2.

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.

Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR.

FEBS Lett. 1999 Jan 25;443(2):121-5.

PMID:
9989588
[PubMed - indexed for MEDLINE]
Free Article
3.

Drug resistance of herpes simplex virus type 1--structural considerations at the molecular level of the thymidine kinase.

Kussmann-Gerber S, Kuonen O, Folkers G, Pilger BD, Scapozza L.

Eur J Biochem. 1998 Jul 15;255(2):472-81.

PMID:
9716390
[PubMed - indexed for MEDLINE]
Free Article
4.

The rational of catalytic activity of herpes simplex virus thymidine kinase. a combined biochemical and quantum chemical study.

Sulpizi M, Schelling P, Folkers G, Carloni P, Scapozza L.

J Biol Chem. 2001 Jun 15;276(24):21692-7. Epub 2001 Mar 21.

PMID:
11262392
[PubMed - indexed for MEDLINE]
Free Article
5.

Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.

Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C, Summers WC, Sanderson MR.

Nat Struct Biol. 1995 Oct;2(10):876-81.

PMID:
7552712
[PubMed - indexed for MEDLINE]
6.

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.

Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L.

Biochemistry. 2000 Aug 8;39(31):9597-603.

PMID:
10924157
[PubMed - indexed for MEDLINE]
7.

Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells.

Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L.

J Biol Chem. 2004 Jul 30;279(31):32832-8. Epub 2004 May 25.

PMID:
15163659
[PubMed - indexed for MEDLINE]
Free Article
8.

Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase.

Spadola L, Novellino E, Folkers G, Scapozza L.

Eur J Med Chem. 2003 Apr;38(4):413-9.

PMID:
12750029
[PubMed - indexed for MEDLINE]
9.

Interaction of the recombinant herpes simplex virus type 1 thymidine kinase with thymidine and aciclovir: a kinetic study.

Kussmann-Gerber S, Wurth C, Scapozza L, Pilger BD, Pliska V, Folkers G.

Nucleosides Nucleotides. 1999 Mar;18(3):311-30.

PMID:
10358938
[PubMed - indexed for MEDLINE]
10.

The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.

Wild K, Bohner T, Folkers G, Schulz GE.

Protein Sci. 1997 Oct;6(10):2097-106.

PMID:
9336833
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Computer-aided active-site-directed modeling of the herpes simplex virus 1 and human thymidine kinase.

Folkers G, Trumpp-Kallmeyer S, Gutbrod O, Krickl S, Fetzer J, Keil GM.

J Comput Aided Mol Des. 1991 Oct;5(5):385-404.

PMID:
1663155
[PubMed - indexed for MEDLINE]
12.

Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.

Vogt J, Perozzo R, Pautsch A, Prota A, Schelling P, Pilger B, Folkers G, Scapozza L, Schulz GE.

Proteins. 2000 Dec 1;41(4):545-53.

PMID:
11056041
[PubMed - indexed for MEDLINE]
13.
14.

Integrated homology modelling and X-ray study of herpes simplex virus I thymidine kinase: a case study.

Folkers G, Alber F, Amrhein I, Behrends H, Bohner T, Gerber S, Kuonen O, Scapozza L.

J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):475-94. Review.

PMID:
9029509
[PubMed - indexed for MEDLINE]
15.

Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase.

Hussein IT, Miguel RN, Tiley LS, Field HJ.

Arch Virol. 2008;153(3):495-505. doi: 10.1007/s00705-007-0021-6. Epub 2008 Jan 15.

PMID:
18196203
[PubMed - indexed for MEDLINE]
16.

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.

Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A.

J Biol Chem. 2006 Jul 14;281(28):19273-9. Epub 2006 May 15.

PMID:
16702226
[PubMed - indexed for MEDLINE]
Free Article
17.

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino JJ, Wright GE, Eberle R, Black DH, Medveczky P, Medveczky M, Shugar D.

Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. Epub 2007 Apr 16.

PMID:
17438061
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mutations distal to the substrate site can affect varicella zoster virus thymidine kinase activity: implications for drug design.

El Omari K, Liekens S, Bird LE, Balzarini J, Stammers DK.

Mol Pharmacol. 2006 Jun;69(6):1891-6. Epub 2006 Mar 23.

PMID:
16556772
[PubMed - indexed for MEDLINE]
Free Article
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