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Results: 1 to 20 of 115

1.

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, Edelberg JM, Rosenberg RD.

J Clin Invest. 1998 May 1;101(9):1983-91.

PMID:
9576763
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H.

Nat Med. 2003 Mar;9(3):331-7. Epub 2003 Feb 10.

PMID:
12579195
[PubMed - indexed for MEDLINE]
3.

Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1.

Keller TT, van der Sluijs KF, de Kruif MD, Gerdes VE, Meijers JC, Florquin S, van der Poll T, van Gorp EC, Brandjes DP, Büller HR, Levi M.

Circ Res. 2006 Nov 24;99(11):1261-9. Epub 2006 Oct 26.

PMID:
17068293
[PubMed - indexed for MEDLINE]
Free Article
4.

Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block.

Isermann B, Hendrickson SB, Hutley K, Wing M, Weiler H.

Development. 2001 Mar;128(6):827-38.

PMID:
11222138
[PubMed - indexed for MEDLINE]
Free Article
5.

Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development.

Conway EM, Pollefeyt S, Cornelissen J, DeBaere I, Steiner-Mosonyi M, Weitz JI, Weiler-Guettler H, Carmeliet P, Collen D.

Blood. 1999 May 15;93(10):3442-50.

PMID:
10233896
[PubMed - indexed for MEDLINE]
Free Article
6.

Characterization of a mouse model for thrombomodulin deficiency.

Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andrian UH, Weitz JI.

Arterioscler Thromb Vasc Biol. 2001 Sep;21(9):1531-7.

PMID:
11557684
[PubMed - indexed for MEDLINE]
Free Article
7.

Mouse models of thrombosis: thrombomodulin.

Weiler H.

Thromb Haemost. 2004 Sep;92(3):467-77. Review.

PMID:
15351842
[PubMed - indexed for MEDLINE]
8.

Spontaneous thrombosis in mice carrying the factor V Leiden mutation.

Cui J, Eitzman DT, Westrick RJ, Christie PD, Xu ZJ, Yang AY, Purkayastha AA, Yang TL, Metz AL, Gallagher KP, Tyson JA, Rosenberg RD, Ginsburg D.

Blood. 2000 Dec 15;96(13):4222-6.

PMID:
11110695
[PubMed - indexed for MEDLINE]
Free Article
9.

Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos.

Weiler-Guettler H, Aird WC, Rayburn H, Husain M, Rosenberg RD.

Development. 1996 Jul;122(7):2271-81.

PMID:
8681807
[PubMed - indexed for MEDLINE]
Free Article
10.

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis.

Isermann B, Hendrickson SB, Zogg M, Wing M, Cummiskey M, Kisanuki YY, Yanagisawa M, Weiler H.

J Clin Invest. 2001 Aug;108(4):537-46.

PMID:
11518727
[PubMed - indexed for MEDLINE]
Free PMC Article
11.
12.

Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.

Sood R, Sholl L, Isermann B, Zogg M, Coughlin SR, Weiler H.

Blood. 2008 Aug 1;112(3):585-91. doi: 10.1182/blood-2007-09-111302. Epub 2008 May 19.

PMID:
18490515
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

Healy AM, Rayburn HB, Rosenberg RD, Weiler H.

Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):850-4.

PMID:
7846065
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.

Van de Wouwer M, Collen D, Conway EM.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1374-83. Epub 2004 Jun 3. Review.

PMID:
15178554
[PubMed - indexed for MEDLINE]
Free Article
15.

Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin deposition.

Healy AM, Hancock WW, Christie PD, Rayburn HB, Rosenberg RD.

Blood. 1998 Dec 1;92(11):4188-97.

PMID:
9834223
[PubMed - indexed for MEDLINE]
Free Article
16.

Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge.

Castellino FJ, Liang Z, Volkir SP, Haalboom E, Martin JA, Sandoval-Cooper MJ, Rosen ED.

Thromb Haemost. 2002 Sep;88(3):462-72.

PMID:
12353077
[PubMed - indexed for MEDLINE]
17.

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

Gu JM, Crawley JT, Ferrell G, Zhang F, Li W, Esmon NL, Esmon CT.

J Biol Chem. 2002 Nov 8;277(45):43335-43. Epub 2002 Sep 5.

PMID:
12218060
[PubMed - indexed for MEDLINE]
Free Article
18.

Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide.

Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, Ten Cate H, van der Poll T.

Blood. 2004 Mar 1;103(5):1702-9. Epub 2003 Oct 30.

PMID:
14592828
[PubMed - indexed for MEDLINE]
Free Article
19.

Myocardial infarction and the balance between fibrin deposition and removal.

Nesheim M.

Ital Heart J. 2001 Sep;2(9):641-5. Review.

PMID:
11666089
[PubMed - indexed for MEDLINE]
20.

Polymorphisms in the endothelial protein C receptor gene and thrombophilia.

Medina P, Navarro S, Estellés A, España F.

Thromb Haemost. 2007 Sep;98(3):564-9. Review.

PMID:
17849044
[PubMed - indexed for MEDLINE]

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