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Items: 1 to 20 of 204

1.

Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors.

Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH.

Exp Parasitol. 1997 Nov;87(3):212-21.

PMID:
9371086
2.

Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids.

Sakanari JA, Nadler SA, Chan VJ, Engel JC, Leptak C, Bouvier J.

Exp Parasitol. 1997 Jan;85(1):63-76.

PMID:
9024203
3.

The impact of whole genome sequence data on drug discovery--a malaria case study.

Joachimiak MP, Chang C, Rosenthal PJ, Cohen FE.

Mol Med. 2001 Oct;7(10):698-710.

4.

S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.

Alves LC, Melo RL, Sanderson SJ, Mottram JC, Coombs GH, Caliendo G, Santagada V, Juliano L, Juliano MA.

Eur J Biochem. 2001 Mar;268(5):1206-12.

5.

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Desai PV, Patny A, Sabnis Y, Tekwani B, Gut J, Rosenthal P, Srivastava A, Avery M.

J Med Chem. 2004 Dec 16;47(26):6609-15.

PMID:
15588096
7.

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.

Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ.

Bioorg Med Chem. 1998 Dec;6(12):2477-94.

PMID:
9925304
8.

Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae.

Loukas A, Selzer PM, Maizels RM.

Mol Biochem Parasitol. 1998 May 1;92(2):275-89.

PMID:
9657332
9.

Metal compounds for the treatment of parasitic diseases.

Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH.

J Inorg Biochem. 2008 Oct;102(10):1839-45. doi: 10.1016/j.jinorgbio.2008.05.010. Epub 2008 Jun 4. Erratum in: J Inorg Biochem. 2009 May;103(5):869.

PMID:
18684510
11.

Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum.

Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH.

Mol Biochem Parasitol. 2008 Aug;160(2):129-37. doi: 10.1016/j.molbiopara.2008.05.001. Epub 2008 May 8.

PMID:
18554733
12.

Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.

Desai PV, Patny A, Gut J, Rosenthal PJ, Tekwani B, Srivastava A, Avery M.

J Med Chem. 2006 Mar 9;49(5):1576-84.

PMID:
16509575
13.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

Mol Med. 2000 Aug;6(8):660-9.

14.

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.

Chan VJ, Selzer PM, McKerrow JH, Sakanari JA.

Biochem J. 1999 May 15;340 ( Pt 1):113-7.

15.

An approach to computer-aided inhibitor design: application to cathepsin L.

Sudarsanam S, Virca GD, March CJ, Srinivasan S.

J Comput Aided Mol Des. 1992 Jun;6(3):223-33.

PMID:
1517775
16.

Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.

Yong V, Schmitz V, Vannier-Santos MA, de Lima AP, Lalmanach G, Juliano L, Gauthier F, Scharfstein J.

Mol Biochem Parasitol. 2000 Jun;109(1):47-59.

PMID:
10924756
17.

The baculovirus cysteine protease has a cathepsin B-like S2-subsite specificity.

Brömme D, Okamoto K.

Biol Chem Hoppe Seyler. 1995 Oct;376(10):611-5.

PMID:
8590630
18.

Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana.

Alves LC, St Hilaire PM, Meldal M, Sanderson SJ, Mottram JC, Coombs GH, Juliano L, Juliano MA.

Mol Biochem Parasitol. 2001 Apr 25;114(1):81-8.

PMID:
11356516
19.

Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.

Pandey KC, Barkan DT, Sali A, Rosenthal PJ.

PLoS One. 2009 May 27;4(5):e5694. doi: 10.1371/journal.pone.0005694.

20.

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.

Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G.

J Mol Biol. 2007 Aug 3;371(1):137-53. Epub 2007 May 10.

PMID:
17561110
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