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Results: 1 to 20 of 309

1.

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.

Heyes MP, Chen CY, Major EO, Saito K.

Biochem J. 1997 Sep 1;326 ( Pt 2):351-6.

PMID:
9291104
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).

Saito K, Chen CY, Masana M, Crowley JS, Markey SP, Heyes MP.

Biochem J. 1993 Apr 1;291 ( Pt 1):11-4.

PMID:
8471029
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

Heyes MP, Saito K, Major EO, Milstien S, Markey SP, Vickers JH.

Brain. 1993 Dec;116 ( Pt 6):1425-50.

PMID:
8293279
[PubMed - indexed for MEDLINE]
4.

Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.

Saito K, Nowak TS Jr, Suyama K, Quearry BJ, Saito M, Crowley JS, Markey SP, Heyes MP.

J Neurochem. 1993 Dec;61(6):2061-70.

PMID:
8245962
[PubMed - indexed for MEDLINE]
5.

Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

Naritsin DB, Saito K, Markey SP, Chen CY, Heyes MP.

J Neurochem. 1995 Nov;65(5):2217-26.

PMID:
7595510
[PubMed - indexed for MEDLINE]
6.

Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.

Alberati-Giani D, Ricciardi-Castagnoli P, Köhler C, Cesura AM.

J Neurochem. 1996 Mar;66(3):996-1004.

PMID:
8769859
[PubMed - indexed for MEDLINE]
7.

Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.

Heyes MP, Saito K, Chen CY, Proescholdt MG, Nowak TS Jr, Li J, Beagles KE, Proescholdt MA, Zito MA, Kawai K, Markey SP.

J Neurochem. 1997 Oct;69(4):1519-29.

PMID:
9326281
[PubMed - indexed for MEDLINE]
8.

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.

Saito K, Markey SP, Heyes MP.

Neuroscience. 1992 Nov;51(1):25-39.

PMID:
1465184
[PubMed - indexed for MEDLINE]
9.

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.

Heyes MP, Achim CL, Wiley CA, Major EO, Saito K, Markey SP.

Biochem J. 1996 Dec 1;320 ( Pt 2):595-7.

PMID:
8973572
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

Saito K, Crowley JS, Markey SP, Heyes MP.

J Biol Chem. 1993 Jul 25;268(21):15496-503.

PMID:
8340378
[PubMed - indexed for MEDLINE]
Free Article
12.

Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.

Saito K, Nowak TS Jr, Markey SP, Heyes MP.

J Neurochem. 1993 Jan;60(1):180-92.

PMID:
8417138
[PubMed - indexed for MEDLINE]
13.
14.

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.

Guillemin GJ, Smythe G, Takikawa O, Brew BJ.

Glia. 2005 Jan 1;49(1):15-23.

PMID:
15390107
[PubMed - indexed for MEDLINE]
15.

Characteristics of interferon induced tryptophan metabolism in human cells in vitro.

Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H.

Biochim Biophys Acta. 1989 Jul 11;1012(2):140-7.

PMID:
2500976
[PubMed - indexed for MEDLINE]
16.

Kynurenine pathway metabolism in human astrocytes.

Guillemin GJ, Kerr SJ, Smythe GA, Armati PJ, Brew BJ.

Adv Exp Med Biol. 1999;467:125-31.

PMID:
10721049
[PubMed - indexed for MEDLINE]
17.

Chronic effects of gamma-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice.

Saito K, Markey SP, Heyes MP.

Brain Res. 1991 Apr 12;546(1):151-4.

PMID:
1830237
[PubMed - indexed for MEDLINE]
18.

3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma.

Morita T, Saito K, Takemura M, Maekawa N, Fujigaki S, Fujii H, Wada H, Takeuchi S, Noma A, Seishima M.

Ann Clin Biochem. 2001 May;38(Pt 3):242-51.

PMID:
11392499
[PubMed - indexed for MEDLINE]
19.

Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.

Saito K, Fujigaki S, Heyes MP, Shibata K, Takemura M, Fujii H, Wada H, Noma A, Seishima M.

Am J Physiol Renal Physiol. 2000 Sep;279(3):F565-72.

PMID:
10966936
[PubMed - indexed for MEDLINE]
Free Article
20.

Expression of the kynurenine pathway enzymes in human microglia and macrophages.

Guillemin GJ, Smith DG, Smythe GA, Armati PJ, Brew BJ.

Adv Exp Med Biol. 2003;527:105-12.

PMID:
15206722
[PubMed - indexed for MEDLINE]

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