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Results: 1 to 20 of 212

1.

Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.

Monge A, Alvarez E, San Martín C, Nadal E, Ruiz I, Font M, Martínez-Irujo JJ, Santiago E, Prieto I, Lasarte JJ, Sarobe P, Borrás F.

Drug Des Discov. 1997 Apr;14(4):291-303.

PMID:
9197980
[PubMed - indexed for MEDLINE]
2.

Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives.

Font M, Monge A, Alvarez E, Cuartero A, Losa MJ, Fidalgo MJ, SanMartín C, Nadal E, Ruiz I, Merino I, Martínez-Irujo JJ, Alberdi E, Santiago E, Prieto I, Lasarte JJ, Sarobe P, Borrás F.

Drug Des Discov. 1997 Apr;14(4):305-32.

PMID:
9197981
[PubMed - indexed for MEDLINE]
3.

Structure-activity relationships in quinoline Reissert derivatives with HIV-1 reverse transcriptase inhibitory activity.

Font M, Monge A, Ruiz I, Heras B.

Drug Des Discov. 1997 Apr;14(4):259-72.

PMID:
9197978
[PubMed - indexed for MEDLINE]
4.

Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.

Campiani G, Morelli E, Fabbrini M, Nacci V, Greco G, Novellino E, Ramunno A, Maga G, Spadari S, Caliendo G, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Nacca A, Caccia S.

J Med Chem. 1999 Oct 21;42(21):4462-70.

PMID:
10543890
[PubMed - indexed for MEDLINE]
5.

A dipyrido [2,3-b:3',2'-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine.

Dyatkin AB, Brickwood JR, Proudfoot JR.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2169-72.

PMID:
9873507
[PubMed - indexed for MEDLINE]
6.

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.

Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C.

Chem Biodivers. 2009 Apr;6(4):561-8. doi: 10.1002/cbdv.200800163.

PMID:
19353537
[PubMed - indexed for MEDLINE]
7.

Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.

Arranz ME, Díaz JA, Ingate ST, Witvrouw M, Pannecouque C, Balzarini J, De Clercq E, Vega S.

Bioorg Med Chem. 1999 Dec;7(12):2811-22.

PMID:
10658585
[PubMed - indexed for MEDLINE]
8.

4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.

Benjahad A, Croisy M, Monneret C, Bisagni E, Mabire D, Coupa S, Poncelet A, Csoka I, Guillemont J, Meyer C, Andries K, Pauwels R, de Béthune MP, Himmel DM, Das K, Arnold E, Nguyen CH, Grierson DS.

J Med Chem. 2005 Mar 24;48(6):1948-64.

PMID:
15771439
[PubMed - indexed for MEDLINE]
9.

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

Campiani G, Aiello F, Fabbrini M, Morelli E, Ramunno A, Armaroli S, Nacci V, Garofalo A, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Ventura L, Bongiovanni B, Capozzi M, Bolacchi F, Marini S, Coletta M, Guiso G, Caccia S.

J Med Chem. 2001 Feb 1;44(3):305-15.

PMID:
11462972
[PubMed - indexed for MEDLINE]
10.

Structure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus.

Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM.

Antivir Chem Chemother. 1999 Sep;10(5):233-40.

PMID:
10574178
[PubMed - indexed for MEDLINE]
11.

Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV.

Nugent RA, Schlachter ST, Murphy MJ, Cleek GJ, Poel TJ, Wishka DG, Graber DR, Yagi Y, Keiser BJ, Olmsted RA, Kopta LA, Swaney SM, Poppe SM, Morris J, Tarpley WG, Thomas RC.

J Med Chem. 1998 Sep 24;41(20):3793-803.

PMID:
9748354
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.

Roth T, Morningstar ML, Boyer PL, Hughes SH, Buckheit RW Jr, Michejda CJ.

J Med Chem. 1997 Dec 19;40(26):4199-207.

PMID:
9435891
[PubMed - indexed for MEDLINE]
13.

Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ma XD, Zhang X, Yang SQ, Dai HF, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE.

Bioorg Med Chem. 2011 Aug 15;19(16):4704-9. doi: 10.1016/j.bmc.2011.07.003. Epub 2011 Jul 13.

PMID:
21788138
[PubMed - indexed for MEDLINE]
14.

Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Liang YH, Feng XQ, Zeng ZS, Chen FE, Balzarini J, Pannecouque C, De Clercq E.

ChemMedChem. 2009 Sep;4(9):1537-45. doi: 10.1002/cmdc.200900212.

PMID:
19591191
[PubMed - indexed for MEDLINE]
15.

Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.

Ragno R, Mai A, Sbardella G, Artico M, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, La Colla P.

J Med Chem. 2004 Feb 12;47(4):928-34.

PMID:
14761194
[PubMed - indexed for MEDLINE]
16.

Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents.

Mahajan DH, Pannecouque C, De Clercq E, Chikhalia KH.

Arch Pharm (Weinheim). 2009 May;342(5):281-90. doi: 10.1002/ardp.200800149.

PMID:
19415671
[PubMed - indexed for MEDLINE]
17.

Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.

Su DS, Lim JJ, Tinney E, Wan BL, Young MB, Anderson KD, Rudd D, Munshi V, Bahnck C, Felock PJ, Lu M, Lai MT, Touch S, Moyer G, Distefano DJ, Flynn JA, Liang Y, Sanchez R, Prasad S, Yan Y, Perlow-Poehnelt R, Torrent M, Miller M, Vacca JP, Williams TM, Anthony NJ.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5119-23. doi: 10.1016/j.bmcl.2009.07.031. Epub 2009 Jul 10.

PMID:
19631528
[PubMed - indexed for MEDLINE]
18.

Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

Genin MJ, Biles C, Keiser BJ, Poppe SM, Swaney SM, Tarpley WG, Yagi Y, Romero DL.

J Med Chem. 2000 Mar 9;43(5):1034-40.

PMID:
10715167
[PubMed - indexed for MEDLINE]
19.

Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Sahlberg C, Noréen R, Engelhardt P, Högberg M, Kangasmetsä J, Vrang L, Zhang H.

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1511-6.

PMID:
9873380
[PubMed - indexed for MEDLINE]
20.

Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.

Romero DL, Olmsted RA, Poel TJ, Morge RA, Biles C, Keiser BJ, Kopta LA, Friis JM, Hosley JD, Stefanski KJ, Wishka DG, Evans DB, Morris J, Stehle RG, Sharma SK, Yagi Y, Voorman RL, Adams WJ, Tarpley WG, Thomas RC.

J Med Chem. 1996 Sep 13;39(19):3769-89.

PMID:
8809165
[PubMed - indexed for MEDLINE]

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