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ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP.

Oncogene. 1997 May 8;14(18):2175-88. Erratum in: Oncogene 1997 Dec 4;15(23):2883.


Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.

Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T.

Oncogene. 1997 Jan 30;14(4):439-49.


Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis.

Sarris AH, Luthra R, Papadimitracopoulou V, Waasdorp M, Dimopoulos MA, McBride JA, Cabanillas F, Duvic M, Deisseroth A, Morris SW, Pugh WC.

Blood. 1996 Sep 1;88(5):1771-9.


Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).

Ouyang T, Bai RY, Bassermann F, von Klitzing C, Klumpen S, Miething C, Morris SW, Peschel C, Duyster J.

J Biol Chem. 2003 Aug 8;278(32):30028-36. Epub 2003 May 14.


Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT.

Science. 1994 Mar 4;263(5151):1281-4. Erratum in: Science. 1995 Jan 20;267(5196):316-7.


Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.

Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E.

Genes Chromosomes Cancer. 2003 Aug;37(4):427-32.


Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G.

Biochem J. 2010 Sep 15;430(3):425-37. doi: 10.1042/BJ20100609.


The t(2;5) in human lymphomas.

Kadin ME, Morris SW.

Leuk Lymphoma. 1998 Apr;29(3-4):249-56. Review.


Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin's lymphoma by two-color fluorescence in situ hybridization.

Mathew P, Sanger WG, Weisenburger DD, Valentine M, Valentine V, Pickering D, Higgins C, Hess M, Cui X, Srivastava DK, Morris SW.

Blood. 1997 Mar 1;89(5):1678-85.


Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site.

Ladanyi M, Cavalchire G.

Genes Chromosomes Cancer. 1996 Mar;15(3):173-7.


A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster.

Lorén CE, Englund C, Grabbe C, Hallberg B, Hunter T, Palmer RH.

EMBO Rep. 2003 Aug;4(8):781-6. Epub 2003 Jul 4.


Genomic DNA amplification and the detection of t(2;5)(p23;q35) in lymphoid neoplasms.

Sarris AH, Luthra R, Cabanillas F, Morris SW, Pugh WC.

Leuk Lymphoma. 1998 May;29(5-6):507-14.


Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice.

Kuefer MU, Look AT, Pulford K, Behm FG, Pattengale PK, Mason DY, Morris SW.

Blood. 1997 Oct 15;90(8):2901-10.


Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1.

Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, Delsol G, Mason DY.

Blood. 1997 Feb 15;89(4):1394-404.


Xenopus muscle-specific kinase: molecular cloning and prominent expression in neural tissues during early embryonic development.

Fu AK, Smith FD, Zhou H, Chu AH, Tsim KW, Peng BH, Ip NY.

Eur J Neurosci. 1999 Feb;11(2):373-82.


Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).

Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, Yamamoto T.

Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4181-6.


Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis.

Ma Z, Cools J, Marynen P, Cui X, Siebert R, Gesk S, Schlegelberger B, Peeters B, De Wolf-Peeters C, Wlodarska I, Morris SW.

Blood. 2000 Mar 15;95(6):2144-9.


Mapping of genomic t(2;5)(p23;q35) break points in patients with anaplastic large cell lymphoma by sequencing long-range PCR products.

Luthra R, Pugh WC, Waasdorp M, Morris W, Cabanillas F, Chan PK, Sarris AH.

Hematopathol Mol Hematol. 1998;11(3-4):173-83.

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