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Items: 1 to 20 of 99

1.

Chimeric proteins can exceed the sum of their parts: implications for evolution and protein design.

Campbell RK, Bergert ER, Wang Y, Morris JC, Moyle WR.

Nat Biotechnol. 1997 May;15(5):439-43.

PMID:
9131622
3.

Co-evolution of ligand-receptor pairs.

Moyle WR, Campbell RK, Myers RV, Bernard MP, Han Y, Wang X.

Nature. 1994 Mar 17;368(6468):251-5.

PMID:
8145825
4.

Functional homodimeric glycoprotein hormones: implications for hormone action and evolution.

Moyle WR, Myers RV, Wang Y, Han Y, Lin W, Kelley GL, Ehrlich PH, Rao SN, Bernard MP.

Chem Biol. 1998 May;5(5):241-54.

PMID:
9646940
5.

Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit.

Fares FA, Suganuma N, Nishimori K, LaPolt PS, Hsueh AJ, Boime I.

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4304-8.

6.

Engineering a potential antagonist of human thyrotropin and thyroid-stimulating antibody.

Fares FA, Levi F, Reznick AZ, Kraiem Z.

J Biol Chem. 2001 Feb 16;276(7):4543-8. Epub 2000 Nov 16.

8.

Receptor-specific activity of heteromeric thyrotropin (TSH) analogs: development of synthetic TSH antagonists.

Sheehan MT, Morbeck DE, Bergert ER, McCormick DJ, Milius RP, Morris JC.

Pept Res. 1995 Sep-Oct;8(5):264-71.

PMID:
8589548
9.
10.

A single-chain tetradomain glycoprotein hormone analog elicits multiple hormone activities in vivo.

Garcia-Campayo V, Boime I, Ma X, Daphna-Iken D, Kumar TR.

Biol Reprod. 2005 Feb;72(2):301-8. Epub 2004 Sep 22. Erratum in: Biol Reprod. 2005 Sep;73(3):579.

11.

The position of the alpha and beta subunits in a single chain variant of human chorionic gonadotropin affects the heterodimeric interaction of the subunits and receptor-binding epitopes.

Ben-Menahem D, Jablonka-Shariff A, Hyde RK, Pixley MR, Srivastava S, Berger P, Boime I.

J Biol Chem. 2001 Aug 10;276(32):29871-9. Epub 2001 Jun 4.

12.

Addition of an N-terminal dimerization domain promotes assembly of hCG analogs: implications for subunit combination and structure-function analysis.

Lin W, Ransom MX, Myers RV, Bernard MP, Moyle WR.

Mol Cell Endocrinol. 1999 Jun 25;152(1-2):91-8.

PMID:
10432227
13.

Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity.

Xing Y, Lin W, Jiang M, Myers RV, Cao D, Bernard MP, Moyle WR.

J Biol Chem. 2001 Dec 14;276(50):46953-60. Epub 2001 Oct 8.

14.

Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem.

Sugahara T, Pixley MR, Minami S, Perlas E, Ben-Menahem D, Hsueh AJ, Boime I.

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2041-5.

15.

Bifunctional hCG analogs adopt different conformations in LH and FSH receptor complexes.

Wang Y, Bernard MP, Moyle WR.

Mol Cell Endocrinol. 2000 Dec 22;170(1-2):67-77.

PMID:
11162891
17.

Engineering human glycoprotein hormone superactive analogues.

Szkudlinski MW, Teh NG, Grossmann M, Tropea JE, Weintraub BD.

Nat Biotechnol. 1996 Oct;14(10):1257-63.

PMID:
9631089
18.

Biological properties of a novel follicle-stimulating hormone/human chorionic gonadotropin chimeric gonadotropin.

Garone LM, Ammannati E, Brush TS, Fischer DJ, Tos EG, Luo J, Altobello KL, Ciampolillo C, Ihley TM, Kurosawa E, Tiebout A, McKenna S.

Endocrinology. 2006 Sep;147(9):4205-12. Epub 2006 Jun 22.

PMID:
16794004
19.

hCG beta residues 94-96 alter LH activity without appearing to make key receptor contacts.

Han Y, Bernard MP, Moyle WR.

Mol Cell Endocrinol. 1996 Nov 29;124(1-2):151-61. Erratum in: Mol Cell Endocrinol 1997 May 16;129(2):237-9.

PMID:
9027334
20.

A rational design strategy for protein hormone superagonists.

Grossmann M, Leitolf H, Weintraub BD, Szkudlinski MW.

Nat Biotechnol. 1998 Sep;16(9):871-5.

PMID:
9743123
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