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Results: 1 to 20 of 201

1.

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.

Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C.

Mol Med. 1996 Nov;2(6):673-91.

PMID:
8972483
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
[PubMed - indexed for MEDLINE]
3.

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.

Walter J, Grünberg J, Schindzielorz A, Haass C.

Biochemistry. 1998 Apr 28;37(17):5961-7.

PMID:
9558331
[PubMed - indexed for MEDLINE]
4.

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.

Traffic. 2006 Mar;7(3):354-64.

PMID:
16497228
[PubMed - indexed for MEDLINE]
5.

Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus.

Tan Y, Hong J, Doan T, McConlogue L, Maltese WA.

Biochim Biophys Acta. 1998 Jul 1;1407(1):69-78.

PMID:
9639678
[PubMed - indexed for MEDLINE]
Free Article
6.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
7.

Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

Pradier L, Carpentier N, Delalonde L, Clavel N, Bock MD, Buée L, Mercken L, Tocqué B, Czech C.

Neurobiol Dis. 1999 Feb;6(1):43-55.

PMID:
10078972
[PubMed - indexed for MEDLINE]
8.

Proteolytic processing of Alzheimer's disease associated proteins.

Haass C, Grünberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R.

J Neural Transm Suppl. 1998;53:159-67. Review.

PMID:
9700654
[PubMed - indexed for MEDLINE]
9.

AMY plaques in familial AD: comparison with sporadic Alzheimer's disease.

Lippa CF, Schmidt ML, Nee LE, Bird T, Nochlin D, Hulette C, Mori H, Lee VM, Trojanowski JQ.

Neurology. 2000 Jan 11;54(1):100-4.

PMID:
10636133
[PubMed - indexed for MEDLINE]
10.

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.

Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ.

Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8208-13.

PMID:
9223340
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The presenilins and Alzheimer's disease.

Hutton M, Hardy J.

Hum Mol Genet. 1997;6(10):1639-46. Review.

PMID:
9300655
[PubMed - indexed for MEDLINE]
Free Article
12.

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein.

Blanchard V, Czech C, Bonici B, Clavel N, Gohin M, Dalet K, Revah F, Pradier L, Imperato A, Moussaoui S.

Brain Res. 1997 May 30;758(1-2):209-17.

PMID:
9203550
[PubMed - indexed for MEDLINE]
13.

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.

Weidemann A, Paliga K, Dürrwang U, Czech C, Evin G, Masters CL, Beyreuther K.

Nat Med. 1997 Mar;3(3):328-32.

PMID:
9055862
[PubMed - indexed for MEDLINE]
14.

Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

Mattson MP, Guo Q.

J Neurosci Res. 1997 Nov 15;50(4):505-13. Review.

PMID:
9404712
[PubMed - indexed for MEDLINE]
15.

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

Mattson MP, Guo Q, Furukawa K, Pedersen WA.

J Neurochem. 1998 Jan;70(1):1-14. Review.

PMID:
9422341
[PubMed - indexed for MEDLINE]
16.

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

Suh YH, Checler F.

Pharmacol Rev. 2002 Sep;54(3):469-525. Review. Erratum in: Pharmacol Rev. 2006 Jun;58(2):280.

PMID:
12223532
[PubMed - indexed for MEDLINE]
Free Article
17.

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F.

J Biol Chem. 1997 Feb 7;272(6):3590-8.

PMID:
9013610
[PubMed - indexed for MEDLINE]
Free Article
18.

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms.

Czech C, Tremp G, Pradier L.

Prog Neurobiol. 2000 Mar;60(4):363-84. Review.

PMID:
10670705
[PubMed - indexed for MEDLINE]
19.
20.

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.

Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L.

J Biol Chem. 2001 Jun 8;276(23):20267-79. Epub 2001 Mar 7.

PMID:
11278337
[PubMed - indexed for MEDLINE]
Free Article

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