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Results: 1 to 20 of 228

1.

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.

Scheffner M, Huibregtse JM, Vierstra RD, Howley PM.

Cell. 1993 Nov 5;75(3):495-505.

PMID:
8221889
[PubMed - indexed for MEDLINE]
2.

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

Scheffner M, Huibregtse JM, Howley PM.

Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8797-801.

PMID:
8090726
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2.

Ciechanover A, Shkedy D, Oren M, Bercovich B.

J Biol Chem. 1994 Apr 1;269(13):9582-9.

PMID:
8144545
[PubMed - indexed for MEDLINE]
Free Article
4.

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system.

Shkedy D, Gonen H, Bercovich B, Ciechanover A.

FEBS Lett. 1994 Jul 11;348(2):126-30.

PMID:
8034027
[PubMed - indexed for MEDLINE]
Free Article
5.

Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes.

Stancovski I, Gonen H, Orian A, Schwartz AL, Ciechanover A.

Mol Cell Biol. 1995 Dec;15(12):7106-16.

PMID:
8524278
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade.

Scheffner M, Nuber U, Huibregtse JM.

Nature. 1995 Jan 5;373(6509):81-3.

PMID:
7800044
[PubMed - indexed for MEDLINE]
7.

Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.

Gewin L, Myers H, Kiyono T, Galloway DA.

Genes Dev. 2004 Sep 15;18(18):2269-82.

PMID:
15371341
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5.

Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M.

J Biol Chem. 1996 Feb 2;271(5):2795-800.

PMID:
8576257
[PubMed - indexed for MEDLINE]
Free Article
9.

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

Talis AL, Huibregtse JM, Howley PM.

J Biol Chem. 1998 Mar 13;273(11):6439-45.

PMID:
9497376
[PubMed - indexed for MEDLINE]
Free Article
10.

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.

Huibregtse JM, Scheffner M, Howley PM.

Mol Cell Biol. 1993 Aug;13(8):4918-27.

PMID:
8393140
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.

Gao Q, Kumar A, Singh L, Huibregtse JM, Beaudenon S, Srinivasan S, Wazer DE, Band H, Band V.

Cancer Res. 2002 Jun 1;62(11):3315-21.

PMID:
12036950
[PubMed - indexed for MEDLINE]
Free Article
12.

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3264-8.

PMID:
7724550
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate.

Nuber U, Schwarz SE, Scheffner M.

Eur J Biochem. 1998 Jun 15;254(3):643-9.

PMID:
9688277
[PubMed - indexed for MEDLINE]
Free Article
14.

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

Huibregtse JM, Scheffner M, Howley PM.

Mol Cell Biol. 1993 Feb;13(2):775-84.

PMID:
8380895
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.

Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y.

J Med Virol. 2006 Apr;78(4):501-7.

PMID:
16482544
[PubMed - indexed for MEDLINE]
16.

The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.

Srivenugopal KS, Ali-Osman F.

Oncogene. 2002 Aug 29;21(38):5940-5.

PMID:
12185595
[PubMed - indexed for MEDLINE]
Free Article
17.

The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells.

Traidej M, Chen L, Yu D, Agrawal S, Chen J.

Antisense Nucleic Acid Drug Dev. 2000 Feb;10(1):17-27.

PMID:
10726657
[PubMed - indexed for MEDLINE]
18.

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.

Kao WH, Beaudenon SL, Talis AL, Huibregtse JM, Howley PM.

J Virol. 2000 Jul;74(14):6408-17.

PMID:
10864652
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

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