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Items: 1 to 20 of 193

1.
2.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
3.

Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).

Mitchell LW, Jaffe EK.

Arch Biochem Biophys. 1993 Jan;300(1):169-77.

PMID:
8424649
4.
6.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

7.

Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.

Jaffe EK, Ali S, Mitchell LW, Taylor KM, Volin M, Markham GD.

Biochemistry. 1995 Jan 10;34(1):244-51.

PMID:
7819203
8.
9.

X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution.

Erskine PT, Norton E, Cooper JB, Lambert R, Coker A, Lewis G, Spencer P, Sarwar M, Wood SP, Warren MJ, Shoolingin-Jordan PM.

Biochemistry. 1999 Apr 6;38(14):4266-76.

PMID:
10194344
10.

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.

Frère F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW.

J Mol Biol. 2002 Jul 5;320(2):237-47.

PMID:
12079382
11.

The molecular mechanism of lead inhibition of human porphobilinogen synthase.

Jaffe EK, Martins J, Li J, Kervinen J, Dunbrack RL Jr.

J Biol Chem. 2001 Jan 12;276(2):1531-7.

12.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
13.

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.

Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A.

J Biol Chem. 2002 May 31;277(22):19792-9. Epub 2002 Mar 21.

14.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
15.

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions.

Frankenberg N, Jahn D, Jaffe EK.

Biochemistry. 1999 Oct 19;38(42):13976-82.

PMID:
10529244
16.

Porphobilinogen synthase, the first source of heme's asymmetry.

Jaffe EK.

J Bioenerg Biomembr. 1995 Apr;27(2):169-79. Review.

PMID:
7592564
18.

High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.

Frankenberg N, Erskine PT, Cooper JB, Shoolingin-Jordan PM, Jahn D, Heinz DW.

J Mol Biol. 1999 Jun 11;289(3):591-602.

PMID:
10356331
19.

The porphobilinogen synthase family of metalloenzymes.

Jaffe EK.

Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):115-28. Review.

PMID:
10666591
20.

13C NMR studies of porphobilinogen synthase: observation of intermediates bound to a 280,000-dalton protein.

Jaffe EK, Markham GD.

Biochemistry. 1987 Jul 14;26(14):4258-64. Erratum in: Biochemistry 1987 Dec 1;26(24):8030.

PMID:
3663587
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