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Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis.

Mohamed R, Jayakumar C, Chen F, Fulton D, Stepp D, Gansevoort RT, Ramesh G. Mohamed R, et al. J Am Soc Nephrol. 2016 Mar;27(3):745-65. doi: 10.1681/ASN.2014111136. Epub 2015 Sep 2. J Am Soc Nephrol. 2016. PMID: 26334030 Free PMC article.

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.

You H, Gao T, Raup-Konsavage WM, Cooper TK, Bronson SK, Reeves WB, Awad AS. You H, et al. Kidney Int. 2017 Mar;91(3):671-682. doi: 10.1016/j.kint.2016.09.042. Epub 2016 Dec 1. Kidney Int. 2017. PMID: 27914709 Free PMC article.

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism.

Liang G, Song L, Chen Z, Qian Y, Xie J, Zhao L, Lin Q, Zhu G, Tan Y, Li X, Mohammadi M, Huang Z. Liang G, et al. Kidney Int. 2018 Jan;93(1):95-109. doi: 10.1016/j.kint.2017.05.013. Epub 2017 Jul 24. Kidney Int. 2018. PMID: 28750927 Free PMC article.

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.

Shah A, Xia L, Masson EA, Gui C, Momen A, Shikatani EA, Husain M, Quaggin S, John R, Fantus IG. Shah A, et al. J Am Soc Nephrol. 2015 Dec;26(12):2963-77. doi: 10.1681/ASN.2014050528. Epub 2015 Apr 8. J Am Soc Nephrol. 2015. PMID: 25855771 Free PMC article.

IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice.

Kim KH, Hong GL, Jung DY, Karunasagara S, Jeong WI, Jung JY. Kim KH, et al. Mol Med. 2021 Mar 10;27(1):25. doi: 10.1186/s10020-021-00285-4. Mol Med. 2021. PMID: 33691614 Free PMC article.

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. Wang XX, et al. J Am Soc Nephrol. 2018 Jan;29(1):118-137. doi: 10.1681/ASN.2017020222. Epub 2017 Oct 31. J Am Soc Nephrol. 2018. PMID: 29089371 Free PMC article.

Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats.

Said E, Zaitone SA, Eldosoky M, Elsherbiny NM. Said E, et al. Chem Biol Interact. 2018 Feb 1;281:111-120. doi: 10.1016/j.cbi.2017.12.030. Epub 2017 Dec 30. Chem Biol Interact. 2018. PMID: 29291386

Interleukin 17A promotes diabetic kidney injury.

Ma J, Li YJ, Chen X, Kwan T, Chadban SJ, Wu H. Ma J, et al. Sci Rep. 2019 Feb 19;9(1):2264. doi: 10.1038/s41598-019-38811-4. Sci Rep. 2019. PMID: 30783187 Free PMC article.

The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition.

Wang H, Vinnikov I, Shahzad K, Bock F, Ranjan S, Wolter J, Kashif M, Oh J, Bierhaus A, Nawroth P, Kirschfink M, Conway EM, Madhusudhan T, Isermann B. Wang H, et al. Thromb Haemost. 2012 Dec;108(6):1141-53. doi: 10.1160/TH12-07-0460. Epub 2012 Sep 26. Thromb Haemost. 2012. PMID: 23014597

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy.

Lim JH, Kim HW, Kim MY, Kim TW, Kim EN, Kim Y, Chung S, Kim YS, Choi BS, Kim YS, Chang YS, Kim HW, Park CW. Lim JH, et al. Cell Death Dis. 2018 Feb 15;9(3):270. doi: 10.1038/s41419-018-0324-4. Cell Death Dis. 2018. PMID: 29449563 Free PMC article.

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