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25974877,25942359,24283772,26363555,26858942,17919299,25152895,18422438,24726737,25732698,21831202,25822536,22671973,20883318,21323695,20538090,21704108,26835592,22024175,17240920,25962477,19712772,19733584,22570667,27566581,23103299,23357605,30425711,17074845,19056317,29627232,19500523,17033714,22117839,21256189,15196240,17724075,24980867,12654778,25845290,18163878,20646207,14507310,21676888,19515867,29034213,19133010,20883320,18491134,21211591,16488518,28301284,23943377,24177251,26792673,29847865,18201368,17526747,18808333,18192091,22921259,20186878,25398087,17417685,17697571,21920450,29681409,16239577,16552042,30849108,24214530,24984525,24192709,26901244,16369012,22200502,26509812,33550109,28768668,15195250,33981313,17387166,27727129,21093603,21803102,17056566,26845736,25698492,22761299,25024382,27531823,28877927,22363768,26076321,11342645,27847173,31262260,26927984,23977248,35642945,26521300,26202436,22861360,17502400,28620588,27417661,30830940,26903285,19367339,26091147,25583385,21858087,24863497,24300592,27079930,32983151,29090221,26393347,17911599,21272603,28087528,24152387,30104212,25001602,25467292,21340709,31135967,26373723,36674484,31333655,28318770,24146869,27519524,36081510,29779765,25905680,24498312,28224119,16827893,20685935,31354727,25271291,28930287,34795205,15253152,26111521,25419982,26172261,28242071,29046306,25582686,15683854,12905016,32793184,32942991,31266673,17584076,11034297,20921146,20417300,29545791,28470626,31632413,27251218,10948100,26573837,27941982,29593708,19837843,29085809,31739193,27138226,12757627,23967337,22082615,16861689,29081214,24059063,19752029,22072720,26810060,25424922,22972927,15882432,15502839,29148853,18056388,30274790,15501778,22133873,28711483,29550192,23761657,20944089,12067407,26599077,15039321,22461526,25842959,19052643,26318635,32778586,19364278,25589549,28588103,26425695,12941476,22801575,26245027,28937879,24895310,14977976,25671612,25392011,31950781,17584075,20679438,26552000,29518353,27247233,17671648,9246204,22442674,19023426,12438324,22396020,27222470,27060378,25586105,21887254,31118627,18400977,17671656,29243495,24120457,27865389,28428201,28565847,10382760,31101668,26269537,33549390,28177046,16204627,26098302,9234526,28774560,27093372,16125825,25754202,29924445,29940854,21933877,11880222,19017986,16110326,29045910,27234419,20011592,23458421,27404979,34706102,30258084,11228360,30484328,30327124,22643213,27267270,11737066,9378490,30856410,29341430,16456010,26319069,21856361,25086172,22010821,16177348,28588287,14500526,31082645,12096039,12450689,32887748,17152009,24943726,27450001,11907097,26922320,26716832,22483201,24236077,22711885,17502394,25612873,24012566,29912964,10447775,19635582,24616427,33418045,21603219,25995039,31665996,22144485,30901058,28818565,30579607,23468108,22101830,33097574,18573897,18694298,15845506,15784562,25936724,12438379,25135492,24313934,24920602,9430249,30581437,31014910,36749098,28714174,29699790,28297677,32437421,35858977,32464684,19749443,24250805,35181640,19529771,31244856,11095745,31743110,30175850,21852947,19656992,25540272,26522817,22358359,30446726,20625498,12296851,10064082,28013312,28426145,9178471,19056860,31481412,27322875,28446902,25505299,19222369,16223953,22015391,28087924,19356615,26571296,27815271,29394352,27156616,10727883,36808986,28228322,16552077,31064713,36460380,11940236,11159980,17720625,34467249,27005808,21283805,29535714,31681622,23319735,16174106,34835191,35590145,15557632,27002369,21893541,29554138,34775598,28719821,27865379,35603910,29312295,12534944,29661928,25141829,24013364,29736404,25657094,33382383,26473844,11151032,21603645,22406425,29844233,9234754,16920965,28802412,21197095,11163402,32655570,26021569,22315280,26786657,23133523,15730384,34186276,10496899,16552069,26994939,29996082,8222323,33318140,28219528,23933525,21533158,26568961,30098365,29178041,26119086,21326936,31826664,14571187,31055842,31849980,17596303,15309815,26590147,31497538,28522873,9784532,17266712,27756533,33466444,32295871,35069580,36119106,35493466,24434326,25998552,28463648,21258338,19129468,10496883,12368435,34661897,29675017,28630063,26439698,23283639,29123166,28572807,1465432,25428938,18987165,18524883,29682888,29656063,34702619,24579457,30630695,23028853,26656121,31666281,25424796,33692195,31000412,25627812,22531914,24130497,27010255,24581917,31297119,25637347,12538699,28476627,35700556,27716523,2820881,33542363,11427548,28076390,8748313,35987561,34122406,29618733,27651361,28779291,29727142,18468935,35746553,29800697,9826349,25703559,29504148,33521701,31998295,25639709,27763257,9406344,7507889,23726784,16297449,22125073,29547747,28941991,31541022,27356552,29204139,34572519,36267175,10564555,33037320,31813436,26494773,1729188,19152149,18221509,21124731,21178003,11500410,31244354,15972678,33762199,10320645,24273174,24778634,22396610,15774869,27203133,26980500,12100470,30793629,22815851,19038785,32391021,34707001,29343411,30316693,24395772,28507951,12449388,21736914,14741157,27154390,26774644,17372194,26960944,23486691,35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1,046 results

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Enhanced and durable protective immune responses induced by a cocktail of recombinant BCG strains expressing antigens of multistage of Mycobacterium tuberculosis.

Liang J, Teng X, Yuan X, Zhang Y, Shi C, Yue T, Zhou L, Li J, Fan X. Liang J, et al. Mol Immunol. 2015 Aug;66(2):392-401. doi: 10.1016/j.molimm.2015.04.017. Epub 2015 May 18. Mol Immunol. 2015. PMID: 25974877

A novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice.

Li G, Liu G, Song N, Kong C, Huang Q, Su H, Bi A, Luo L, Zhu L, Xu Y, Wang H. Li G, et al. Mol Immunol. 2015 Aug;66(2):346-56. doi: 10.1016/j.molimm.2015.04.003. Epub 2015 May 18. Mol Immunol. 2015. PMID: 25942359

Immunogenicity and protective efficacy conferred by a novel recombinant Mycobacterium bovis bacillus Calmette-Guérin strain expressing interleukin-12p70 of human cytokine and Ag85A of Mycobacterium tuberculosis fusion protein.

Deng YH, He HY, Zhang FJ. Deng YH, et al. Scand J Immunol. 2013 Dec;78(6):497-506. doi: 10.1111/sji.12116. Scand J Immunol. 2013. PMID: 24283772 Free article.

A live attenuated BCG vaccine overexpressing multistage antigens Ag85B and HspX provides superior protection against Mycobacterium tuberculosis infection.

Yuan X, Teng X, Jing Y, Ma J, Tian M, Yu Q, Zhou L, Wang R, Wang W, Li L, Fan X. Yuan X, et al. Appl Microbiol Biotechnol. 2015 Dec;99(24):10587-95. doi: 10.1007/s00253-015-6962-x. Epub 2015 Sep 12. Appl Microbiol Biotechnol. 2015. PMID: 26363555

Evaluation of Immunogenicity and Protective Efficacy Elicited by Mycobacterium bovis BCG Overexpressing Ag85A Protein against Mycobacterium tuberculosis Aerosol Infection.

Xu ZZ, Chen X, Hu T, Meng C, Wang XB, Rao Y, Zhang XM, Yin YL, Pan ZM, Jiao XA. Xu ZZ, et al. Front Cell Infect Microbiol. 2016 Jan 28;6:3. doi: 10.3389/fcimb.2016.00003. eCollection 2016. Front Cell Infect Microbiol. 2016. PMID: 26858942 Free PMC article.

Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice.

Xu Y, Zhu B, Wang Q, Chen J, Qie Y, Wang J, Wang H, Wang B, Wang H. Xu Y, et al. FEMS Immunol Med Microbiol. 2007 Dec;51(3):480-7. doi: 10.1111/j.1574-695X.2007.00322.x. Epub 2007 Oct 4. FEMS Immunol Med Microbiol. 2007. PMID: 17919299 Free article.

Dose of incorporated immunodominant antigen in recombinant BCG impacts modestly on Th1 immune response and protective efficiency against Mycobacterium tuberculosis in mice.

Ma H, Wu K, Liu F, Yang H, Kang H, Chen NN, Yuan Q, Zhou WJ, Fan XY. Ma H, et al. J Immunol Res. 2014;2014:196124. doi: 10.1155/2014/196124. Epub 2014 Jul 23. J Immunol Res. 2014. PMID: 25152895 Free PMC article.

Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis.

Tang C, Yamada H, Shibata K, Maeda N, Yoshida S, Wajjwalku W, Ohara N, Yamada T, Kinoshita T, Yoshikai Y. Tang C, et al. J Infect Dis. 2008 May 1;197(9):1263-74. doi: 10.1086/586902. J Infect Dis. 2008. PMID: 18422438

Recombinant BCG coexpressing Ag85B, ESAT-6 and Rv3620c elicits specific Th1 immune responses in C57BL/6 mice.

Yang E, Lu Y, Xu Y, Liang Q, Wang C, Wang H, Shen H. Yang E, et al. Microb Pathog. 2014 Apr-May;69-70:53-9. doi: 10.1016/j.micpath.2014.03.011. Epub 2014 Apr 12. Microb Pathog. 2014. PMID: 24726737

Recombinant bacille Calmette-Guerin coexpressing Ag85b, CFP10, and interleukin-12 elicits effective protection against Mycobacterium tuberculosis.

Chen YY, Lin CW, Huang WF, Chang JR, Su IJ, Hsu CH, Cheng HY, Hsu SC, Dou HY. Chen YY, et al. J Microbiol Immunol Infect. 2017 Feb;50(1):90-96. doi: 10.1016/j.jmii.2014.11.019. Epub 2014 Dec 11. J Microbiol Immunol Infect. 2017. PMID: 25732698 Free article.

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