Similar articles for PMID: 25259513

Year	Number of Results
1996	1
2000	1
2002	1
2005	3
2006	12
2007	7
2008	20
2009	13
2010	9
2011	15
2012	9
2013	7
2014	6
2015	4
2016	2
2017	3
2018	2
2019	2
2020	2
2021	1
2024	0

1

Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β-hydroxysteroid dehydrogenase type 2 inhibitors.

Gargano EM, Perspicace E, Hanke N, Carotti A, Marchais-Oberwinkler S, Hartmann RW. Gargano EM, et al. Eur J Med Chem. 2014 Nov 24;87:203-19. doi: 10.1016/j.ejmech.2014.09.061. Epub 2014 Sep 20. Eur J Med Chem. 2014. PMID: 25259513

2

Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.

Marchais-Oberwinkler S, Xu K, Wetzel M, Perspicace E, Negri M, Meyer A, Odermatt A, Möller G, Adamski J, Hartmann RW. Marchais-Oberwinkler S, et al. J Med Chem. 2013 Jan 10;56(1):167-81. doi: 10.1021/jm3014053. Epub 2012 Dec 19. J Med Chem. 2013. PMID: 23145773

3

Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities.

Perspicace E, Cozzoli L, Gargano EM, Hanke N, Carotti A, Hartmann RW, Marchais-Oberwinkler S. Perspicace E, et al. Eur J Med Chem. 2014 Aug 18;83:317-37. doi: 10.1016/j.ejmech.2014.06.036. Epub 2014 Jun 17. Eur J Med Chem. 2014. PMID: 24974351

4

Addressing cytotoxicity of 1,4-biphenyl amide derivatives: Discovery of new potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors.

Gargano EM, Perspicace E, Carotti A, Marchais-Oberwinkler S, Hartmann RW. Gargano EM, et al. Bioorg Med Chem Lett. 2016 Jan 1;26(1):21-4. doi: 10.1016/j.bmcl.2015.11.047. Epub 2015 Nov 23. Bioorg Med Chem Lett. 2016. PMID: 26615885

5

Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors.

Xu K, Al-Soud YA, Wetzel M, Hartmann RW, Marchais-Oberwinkler S. Xu K, et al. Eur J Med Chem. 2011 Dec;46(12):5978-90. doi: 10.1016/j.ejmech.2011.10.010. Epub 2011 Oct 10. Eur J Med Chem. 2011. PMID: 22037253

6

Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.

Vuorinen A, Engeli RT, Leugger S, Kreutz CR, Schuster D, Odermatt A, Matuszczak B. Vuorinen A, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2982-2985. doi: 10.1016/j.bmcl.2017.05.005. Epub 2017 May 4. Bioorg Med Chem Lett. 2017. PMID: 28506753

7

Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.

Abdelsamie AS, Salah M, Siebenbürger L, Hamed MM, Börger C, van Koppen CJ, Frotscher M, Hartmann RW. Abdelsamie AS, et al. Eur J Med Chem. 2019 Sep 15;178:93-107. doi: 10.1016/j.ejmech.2019.05.084. Epub 2019 May 31. Eur J Med Chem. 2019. PMID: 31176098

8

Novel N-methylsulfonamide and retro-N-methylsulfonamide derivatives as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors with good ADME-related physicochemical parameters.

Perspicace E, Giorgio A, Carotti A, Marchais-Oberwinkler S, Hartmann RW. Perspicace E, et al. Eur J Med Chem. 2013 Nov;69:201-15. doi: 10.1016/j.ejmech.2013.08.026. Epub 2013 Aug 29. Eur J Med Chem. 2013. PMID: 24036043

9

Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors.

Marchais-Oberwinkler S, Frotscher M, Ziegler E, Werth R, Kruchten P, Messinger J, Thole H, Hartmann RW. Marchais-Oberwinkler S, et al. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):205-11. doi: 10.1016/j.mce.2008.09.024. Epub 2008 Oct 4. Mol Cell Endocrinol. 2009. PMID: 18950679

10

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis.

Wetzel M, Gargano EM, Hinsberger S, Marchais-Oberwinkler S, Hartmann RW. Wetzel M, et al. Eur J Med Chem. 2012 Jan;47(1):1-17. doi: 10.1016/j.ejmech.2011.09.004. Epub 2011 Sep 8. Eur J Med Chem. 2012. PMID: 21945251

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