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Results: 1 to 20 of 91

1.

Menin determines K-RAS proliferative outputs in endocrine cells.

Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS.

J Clin Invest. 2014 Sep 2;124(9):4093-101. doi: 10.1172/JCI69004. Epub 2014 Aug 18.

PMID:
25133424
[PubMed - in process]
Free PMC Article
2.

K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.

Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M, Roberts TM, Sellers WR, Hofmann F, Maira SM.

PLoS One. 2012;7(8):e44146. doi: 10.1371/journal.pone.0044146. Epub 2012 Aug 31.

PMID:
22952903
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Menin promotes the Wnt signaling pathway in pancreatic endocrine cells.

Chen G, A J, Wang M, Farley S, Lee LY, Lee LC, Sawicki MP.

Mol Cancer Res. 2008 Dec;6(12):1894-907. doi: 10.1158/1541-7786.MCR-07-2206.

PMID:
19074834
[PubMed - indexed for MEDLINE]
Free Article
4.
5.

The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators.

Shi K, Parekh VI, Roy S, Desai SS, Agarwal SK.

Endocr Relat Cancer. 2013 Feb 18;20(1):111-22. doi: 10.1530/ERC-12-0077. Print 2013 Feb.

PMID:
23419452
[PubMed - indexed for MEDLINE]
Free Article
6.

Mutation of the MENIN gene in sporadic pancreatic endocrine tumors.

Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr, Sawicki MP.

Cancer Res. 1998 Oct 1;58(19):4417-20.

PMID:
9766672
[PubMed - indexed for MEDLINE]
Free Article
7.

Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.

Guo SS, Sawicki MP.

Mol Endocrinol. 2001 Oct;15(10):1653-64. Review.

PMID:
11579199
[PubMed - indexed for MEDLINE]
8.

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

Yip-Schneider MT, Lin A, Barnard D, Sweeney CJ, Marshall MS.

Int J Oncol. 1999 Aug;15(2):271-9.

PMID:
10402237
[PubMed - indexed for MEDLINE]
9.

Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells.

Heinrich EL, Lee W, Lu J, Lowy AM, Kim J.

J Transl Med. 2012 Apr 2;10:68. doi: 10.1186/1479-5876-10-68.

PMID:
22472349
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

miR-24 regulates menin in the endocrine pancreas.

Vijayaraghavan J, Maggi EC, Crabtree JS.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E84-92. doi: 10.1152/ajpendo.00542.2013. Epub 2014 May 13.

PMID:
24824656
[PubMed - indexed for MEDLINE]
11.

ERK2-regulated TIMP1 induces hyperproliferation of K-Ras(G12D)-transformed pancreatic ductal cells.

Botta GP, Reichert M, Reginato MJ, Heeg S, Rustgi AK, Lelkes PI.

Neoplasia. 2013 Apr;15(4):359-72.

PMID:
23555182
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma.

Cavallari I, Silic-Benussi M, Rende F, Martines A, Fogar P, Basso D, Vella MD, Pedrazzoli S, Herman JG, Chieco-Bianchi L, Esposito G, Ciminale V, D'Agostino DM.

Genes Chromosomes Cancer. 2009 May;48(5):383-96. doi: 10.1002/gcc.20650.

PMID:
19170121
[PubMed - indexed for MEDLINE]
13.

Tumour suppressor menin is essential for development of the pancreatic endocrine cells.

Fontanière S, Duvillié B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX.

J Endocrinol. 2008 Nov;199(2):287-98. doi: 10.1677/JOE-08-0289. Epub 2008 Sep 4.

PMID:
18772165
[PubMed - indexed for MEDLINE]
Free Article
14.

Menin represses tumorigenesis via repressing cell proliferation.

Wu T, Hua X.

Am J Cancer Res. 2011;1(6):726-39. Epub 2011 May 16.

PMID:
22016823
[PubMed]
Free PMC Article
15.

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.

Wu X, Hua X.

Curr Mol Med. 2008 Dec;8(8):805-15. Review.

PMID:
19075677
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Functional interaction between tumor suppressor menin and activator of S-phase kinase.

Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X.

Cancer Res. 2004 Sep 15;64(18):6791-6.

PMID:
15374998
[PubMed - indexed for MEDLINE]
Free Article
17.

Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.

Shi XH, Liang ZY, Ren XY, Liu TH.

Cancer Gene Ther. 2009 Mar;16(3):227-36. doi: 10.1038/cgt.2008.82. Epub 2008 Oct 24.

PMID:
18949011
[PubMed - indexed for MEDLINE]
18.

Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.

Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X.

Cancer Res. 2013 Apr 15;73(8):2650-8. doi: 10.1158/0008-5472.CAN-12-3158. Epub 2013 Apr 11.

PMID:
23580576
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.

Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA, Brown E, Hua X.

Cancer Res. 2006 Jun 1;66(11):5707-15.

PMID:
16740708
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.

Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK.

Cancer Res. 2009 Mar 1;69(5):1858-66. doi: 10.1158/0008-5472.CAN-08-3662. Epub 2009 Feb 10.

PMID:
19208834
[PubMed - indexed for MEDLINE]
Free PMC Article

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