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Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.

Patel R, Gonçalves L, Leveridge M, Mack SR, Hendrick A, Brice NL, Dickenson AH.

Pain. 2014 Oct;155(10):2097-107. doi: 10.1016/j.pain.2014.07.022. Epub 2014 Jul 30.


Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats.

Patel R, Gonçalves L, Newman R, Jiang FL, Goldby A, Reeve J, Hendrick A, Teall M, Hannah D, Almond S, Brice N, Dickenson AH.

J Pharmacol Exp Ther. 2014 Apr;349(1):47-55. doi: 10.1124/jpet.113.211243. Epub 2014 Jan 28.


The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.

Gentry C, Stoakley N, Andersson DA, Bevan S.

Mol Pain. 2010 Jan 21;6:4. doi: 10.1186/1744-8069-6-4.


Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain.

Brignell JL, Chapman V, Kendall DA.

Brain Res. 2008 Jun 18;1215:87-96. doi: 10.1016/j.brainres.2008.03.072. Epub 2008 Apr 9.


Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain.

Su L, Wang C, Yu YH, Ren YY, Xie KL, Wang GL.

BMC Neurosci. 2011 Nov 23;12:120. doi: 10.1186/1471-2202-12-120.


TRPM8 mechanism of cold allodynia after chronic nerve injury.

Xing H, Chen M, Ling J, Tan W, Gu JG.

J Neurosci. 2007 Dec 12;27(50):13680-90.


Plasticity in intact A delta- and C-fibers contributes to cold hypersensitivity in neuropathic rats.

Ji G, Zhou S, Kochukov MY, Westlund KN, Carlton SM.

Neuroscience. 2007 Nov 30;150(1):182-93. Epub 2007 Sep 19.


Topical application of L-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats.

Klein AH, Sawyer CM, Carstens MI, Tsagareli MG, Tsiklauri N, Carstens E.

Behav Brain Res. 2010 Oct 15;212(2):179-86. doi: 10.1016/j.bbr.2010.04.015. Epub 2010 Apr 14.


Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol.

Naziroğlu M, Ozgül C.

Neurochem Res. 2012 Feb;37(2):314-20. doi: 10.1007/s11064-011-0614-z. Epub 2011 Oct 1.


Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.

Knowlton WM, Daniels RL, Palkar R, McCoy DD, McKemy DD.

PLoS One. 2011;6(9):e25894. doi: 10.1371/journal.pone.0025894. Epub 2011 Sep 30.


Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.

Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, Fleetwood-Walker SM, Mitchell R.

Curr Biol. 2006 Aug 22;16(16):1591-605.


TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.

Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.

Pain. 2013 Oct;154(10):2169-77. doi: 10.1016/j.pain.2013.06.043. Epub 2013 Jun 29.


Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats.

Chapman V, Suzuki R, Chamarette HL, Rygh LJ, Dickenson AH.

Pain. 1998 Apr;75(2-3):261-72.


Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons.

Klein AH, Sawyer CM, Takechi K, Davoodi A, Ivanov MA, Carstens MI, Carstens E.

Neuroscience. 2012 Sep 6;219:234-42. doi: 10.1016/j.neuroscience.2012.05.061. Epub 2012 Jun 9.


The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.

Takechi K, Carstens MI, Klein AH, Carstens E.

Anesth Analg. 2013 Apr;116(4):932-8. doi: 10.1213/ANE.0b013e31827f560d. Epub 2013 Jan 21.


Camphor activates and sensitizes transient receptor potential melastatin 8 (TRPM8) to cooling and icilin.

Selescu T, Ciobanu AC, Dobre C, Reid G, Babes A.

Chem Senses. 2013 Sep;38(7):563-75. doi: 10.1093/chemse/bjt027. Epub 2013 Jul 4.


Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

Katsura H, Obata K, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, Fukuoka T, Tokunaga A, Sakagami M, Noguchi K.

Exp Neurol. 2006 Jul;200(1):112-23. Epub 2006 Mar 20.

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